Detailed information NTG0242838

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CGP91_RS09895
• Genome accession: NZ_CP022895
• Coordinates: 1965660..1966703 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 85
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1960660..1971703

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CGP91_RS09865 (CGP91_01826)	-	1961081..1962337 (-)	1257	WP_001793983.1	aminopeptidase	-
CGP91_RS09870 (CGP91_01827)	-	1962340..1962540 (-)	201	WP_000180460.1	DUF1128 family protein	-
CGP91_RS09875 (CGP91_01828)	-	1962687..1963151 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
CGP91_RS09880 (CGP91_01829)	-	1963158..1963433 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CGP91_RS09885 (CGP91_01830)	-	1963711..1964928 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
CGP91_RS09890 (CGP91_01831)	vraR	1965041..1965670 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CGP91_RS09895 (CGP91_01832)	vraS	1965660..1966703 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CGP91_RS09900 (CGP91_01833)	liaF	1966700..1967401 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CGP91_RS09905 (CGP91_01834)	-	1967416..1967802 (-)	387	WP_001110178.1	hypothetical protein	-
CGP91_RS09910 (CGP91_01835)	map	1968019..1968777 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CGP91_RS09930 (CGP91_01836)	-	1969477..1970463 (+)	987	WP_001014423.1	aromatic acid exporter family protein	-
CGP91_RS09935 (CGP91_01837)	-	1970652..1971065 (-)	414	WP_001643743.1	hypothetical protein	-
CGP91_RS09940	-	1971094..1971204 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=242838 CGP91_RS09895 WP_001017131.1 1965660..1966703(-) (vraS) [Staphylococcus aureus strain 85]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=242838 CGP91_RS09895 WP_001017131.1 1965660..1966703(-) (vraS) [Staphylococcus aureus strain 85]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1