Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SM12261_RS08745 Genome accession   NZ_CP028414
Coordinates   1729241..1731190 (-) Length   649 a.a.
NCBI ID   WP_000018200.1    Uniprot ID   -
Organism   Streptococcus mitis NCTC 12261     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1724241..1736190
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS08715 (SM12261_1679) - 1724798..1725742 (+) 945 WP_000815623.1 magnesium transporter CorA family protein -
  SM12261_RS08720 (SM12261_1680) - 1725754..1726431 (+) 678 WP_000078009.1 DUF1129 domain-containing protein -
  SM12261_RS08725 (SM12261_1681) - 1726572..1727606 (+) 1035 WP_000626031.1 S66 family peptidase -
  SM12261_RS08730 (SM12261_1682) - 1727712..1727975 (+) 264 WP_000166114.1 SemiSWEET family transporter -
  SM12261_RS08735 (SM12261_1683) - 1728059..1728622 (-) 564 WP_000166574.1 DNA-3-methyladenine glycosylase I -
  SM12261_RS08740 (SM12261_1684) ruvA 1728632..1729225 (-) 594 WP_000273422.1 Holliday junction branch migration protein RuvA Machinery gene
  SM12261_RS08745 (SM12261_1685) hexB 1729241..1731190 (-) 1950 WP_000018200.1 DNA mismatch repair endonuclease MutL Machinery gene
  SM12261_RS08755 (SM12261_1686) - 1731396..1731836 (+) 441 WP_000861976.1 LytTR family DNA-binding domain-containing protein -
  SM12261_RS08760 (SM12261_1687) - 1731833..1732291 (+) 459 WP_000743962.1 DUF3021 domain-containing protein -
  SM12261_RS08765 (SM12261_1688) nrdI 1732339..1732803 (-) 465 WP_000849612.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  SM12261_RS08770 (SM12261_1689) - 1732881..1733414 (-) 534 WP_000729020.1 hypothetical protein -
  SM12261_RS08775 (SM12261_1690) - 1733475..1734761 (-) 1287 WP_000278883.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73407.76 Da        Isoelectric Point: 5.3675

>NTDB_id=241168 SM12261_RS08745 WP_000018200.1 1729241..1731190(-) (hexB) [Streptococcus mitis NCTC 12261]
MSHIIELPEVLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKIQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMALVSE
AIANSLKEQTLIPDALENLAKSTVRNRQKVEQTILPLKENTLYYEKTESIRSSQAEVADYQVELTEEGQDLTLFAKETLD
QLTKPAKLHFAERKPANYDQLDHPELDLASLDKAYDKLEREESSSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMTHLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=241168 SM12261_RS08745 WP_000018200.1 1729241..1731190(-) (hexB) [Streptococcus mitis NCTC 12261]
ATGTCTCATATTATTGAATTGCCAGAGGTGCTGGCAAACCAGATCGCGGCTGGAGAGGTTATCGAGCGTCCAGCTAGCGT
TGTTAAGGAGCTAGTAGAAAACGCCATTGACGCGGGCTCTAGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGA
AAATCCAAATCACAGATAATGGTCATGGAATTGCCCACGATGAGGTGGAATTGGCCTTGCGTCGTCATGCGACCAGTAAG
ATAAAAAATCAGGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCTTGCCTTCTATCGCTTCTGTTAG
TGTTTTGACCCTTTTGACGGCGGTGGATGGTGCAAGTCATGGAACCAAGCTCGTCGCGCGTGGGGGAGAAGTTGAAGAAG
TCATCCCAGCGACTAGTCCTGTGGGAACCAAGGTTTGTGTGGAGGACCTCTTTTTCAACACGCCTGCCCGCCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGTTGTCTCATATCATTGATATTGTCAATCGTCTGGGCTTGGCCCATCCTGAAATTTCGTT
TAGTTTAATCAGTGATGGCAAGGAGATGACGCGGACAGCTGGGACTGGTCAATTGCGCCAAGCTATCGCAGGAATTTACG
GTTTGGTGAGTGCCAAGAAGATGATTGAAATTGAGAATTCTGACCTAGATTTCGAAATTTCAGGTTTTGTGTCCTTGCCT
GAGTTAACTCGAGCCAACCGCAACTATATCAGTCTCTTCATCAATGGCCGTTATATAAAGAACTTCCTGCTCAATCGTGC
AATTCTAGATGGCTATGGCAGTAAGCTTATGGTAGGCCGTTTTCCACTGGCTGTCATTCACATTCATATCGACCCTTATC
TAGCGGATGTCAATGTACACCCAACCAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGGCGCTGGTCTCAGAA
GCTATTGCAAACAGTCTCAAGGAACAAACCTTGATACCTGATGCCTTGGAAAATCTTGCTAAATCGACCGTGCGCAATCG
TCAAAAGGTGGAGCAGACCATTCTCCCACTCAAAGAAAATACGCTCTACTATGAGAAAACAGAGTCGATAAGATCCAGTC
AAGCTGAGGTGGCTGATTATCAGGTAGAATTAACTGAGGAAGGGCAAGACTTGACTTTGTTTGCCAAGGAAACCTTGGAT
CAGCTAACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAGCTAGATCACCCAGAGTTAGA
CCTTGCGAGTCTTGATAAGGCTTATGACAAGCTGGAGCGAGAAGAATCATCCAGCTTCCCAGAATTGGAATTTTTCGGGC
AAATGCACGGGACTTATCTCTTTGCCCAAGGGCGAGATGGGCTCTATATCATAGACCAGCACGCGGCTCAGGAACGGGTC
AAGTACGAGGAATACCGTGAAAGTATTGGCAATGTTGACCAGAGCCAGCAGCAACTCCTAGTGCCCTATATCTTTGAATT
TCCAGCGGATGATGCTCTTCGTCTCAAGGAAAGAATGACACATTTGGAGGAAGTGGGCGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATCCTGCGTGAACATCCTATTTGGATGGCAGAGGAGGAAATCGAGTCAGGCATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATATCGAGCAGAGTTGGCTATTATGATGTCCTGCAAGCGGTCTAT
CAAGGCCAACCATCGTATTGACGACCATTCGGCTAGACAGCTCCTCTATCAGCTCTCTCAATGTGACAATCCCTATAACT
GTCCCCACGGACGCCCTGTTTTGGTGCATTTTACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

97.689

100

0.977