Detailed information NTG0241067

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: Sp14A_RS08185
• Genome accession: NZ_CP022601
• Coordinates: 1602799..1605057 (+)
• Length: 752 a.a.
• NCBI ID: WP_115130639.1
• Uniprot ID: A0A345VLJ9
• Organism: Streptococcus pluranimalium strain 14A0014
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1605139..1606484	1602799..1605057	flank	82

Gene organization within MGE regions

Location: 1602799..1606484

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Sp14A_RS08185 (Sp14A_16930)	clpE	1602799..1605057 (+)	2259	WP_115130639.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
Sp14A_RS08190 (Sp14A_16950)	-	1605139..1606484 (+)	1346	WP_205407074.1	IS3 family transposase	-

Sequence

Protein

• Length: 752 a.a.
• Molecular weight: 83659.70 Da
• Isoelectric Point: 4.8030

>NTDB_id=241067 Sp14A_RS08185 WP_115130639.1 1602799..1605057(+) (clpE) [Streptococcus pluranimalium strain 14A0014]
MLCQNCQLNESTIHLYTNVNGKQKQVDLCQNCYQIMKTDPKNNLLSNLGRENASSSMNPFFDDFFGDLNNFRAFSGDLPN
SPKTQSGGQGGNNGTGNRHPNAPLGTAQQKPQGLLEEFGINITDIARQGDIDPVIGRDEEILRVIEILNRRTKNNPVLIG
EPGVGKTAVVEGLAQKIVDADVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRQDVILFIDEIHEIVGAG
NAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHHVKYSP
DAIEAAAILSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPQEIDQRLVEAENLKAQATRDEDYERAAYFRDQIAKYK
EMQAQKIDDHDTPVITEQNIEAIIEQKTNIPVGDLKEKEQSQLIHLADDLKSHVIGQDDAVDKIAKAIRRNRVGLGSPNR
PIGSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILL
DEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAREGRTNSVLNQLGDFFSPEFMN
RFDGIIEFKALEKENLLTIVDLMLKDVNDRLATNGLHLDVTEKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLE
NPSEKNLRAIMTSNGNIIIKSNTKAEAVVEEN

Nucleotide

• Length: 2259 bp

>NTDB_id=241067 Sp14A_RS08185 WP_115130639.1 1602799..1605057(+) (clpE) [Streptococcus pluranimalium strain 14A0014]
ATGCTTTGTCAAAATTGTCAATTAAACGAATCAACTATTCATTTATATACTAATGTTAATGGCAAACAAAAACAAGTCGA
TCTTTGCCAAAACTGTTATCAAATCATGAAAACAGATCCCAAAAACAACCTTTTATCTAACCTGGGTCGAGAAAACGCAT
CATCTTCTATGAATCCATTTTTTGATGATTTCTTTGGTGACTTAAATAACTTCCGTGCCTTCAGCGGTGACCTTCCAAAC
AGTCCTAAAACACAATCTGGTGGTCAGGGAGGAAACAACGGAACCGGAAATCGTCATCCAAATGCCCCTCTAGGCACTGC
TCAACAGAAGCCTCAAGGACTCTTAGAAGAGTTCGGTATTAATATCACTGATATTGCACGCCAAGGCGATATTGATCCCG
TTATTGGTCGCGATGAAGAAATCCTTCGTGTTATCGAAATTCTAAACCGTCGTACCAAAAATAATCCTGTCCTCATTGGT
GAGCCAGGTGTTGGTAAAACTGCTGTCGTTGAAGGACTGGCTCAAAAGATTGTTGATGCTGATGTTCCTCAAAAACTCCA
AGGAAAACAAGTCATCCGTTTGGATGTTGTCAGTCTTGTTCAAGGAACTGGCATTCGTGGGCAATTTGAAGAACGTATGC
AAAAACTCATGGAAGAAATCCGTAATCGTCAAGATGTGATTCTCTTCATTGATGAGATTCATGAGATTGTTGGTGCAGGC
AATGCTGGTGATGGAAACATGGACGCCGGTAATATCCTAAAACCTGCTCTAGCTCGCGGTGAGCTACAACTAGTCGGTGC
TACTACTCTCAATGAATATCGTATCATTGAAAAAGATGCTGCTCTGGAACGTCGTATGCAGCCCGTCAAAGTTGATGAGC
CAAGTGTTGAGGAAACTATCACCATCTTAAAAGGTATTCAACCAAAATACGAAGACTATCACCATGTCAAATATAGCCCT
GATGCGATTGAAGCAGCAGCTATCCTCTCCAACCGTTACATTCAAGACCGCTTCCTTCCAGATAAGGCTATCGATCTACT
AGATGAAGCTGGATCTAAAATGAATTTAACCTTAAATTTTGTTGATCCACAAGAAATCGATCAACGTCTGGTGGAAGCCG
AAAACCTCAAAGCTCAAGCGACTCGAGATGAAGATTATGAACGCGCAGCTTATTTCCGTGACCAAATTGCTAAATACAAA
GAAATGCAAGCGCAAAAAATCGATGACCACGACACTCCAGTCATCACTGAACAAAATATCGAAGCCATCATTGAACAAAA
AACTAATATTCCAGTCGGCGATCTCAAAGAAAAAGAACAAAGTCAATTAATTCATTTGGCTGACGACCTTAAATCACACG
TTATTGGACAAGACGATGCTGTTGATAAAATCGCAAAAGCCATTCGTCGTAACCGTGTCGGACTTGGTTCGCCAAATCGC
CCAATCGGCTCCTTCCTCTTTGTTGGTCCAACTGGTGTCGGTAAAACTGAACTCTCAAAACAACTAGCAATCGAGCTCTT
TGGTTCAGCAGACAGCATGATTCGCTTTGATATGTCCGAGTACATGGAAAAACATGCCGTCGCCAAACTTGTCGGGGCTC
CTCCAGGTTATGTTGGTTATGAAGAAGCTGGTCAATTAACAGAAAAAGTTCGTCGCAATCCATACTCACTCATTCTCTTG
GATGAAGTTGAGAAAGCTCACCCAGATGTTATGCATATGTTCTTACAAGTTCTTGACGATGGTCGTTTGACTGATGGTCA
AGGTCGTACCGTTAGCTTCAAAGATACCATTATCATCATGACTTCTAATGCTGGAACAGGCAAGGTTGAAGCTTCTGTTG
GATTTGGAGCAGCTCGTGAAGGTCGTACTAACTCCGTTCTTAACCAACTTGGAGACTTCTTTAGCCCAGAATTCATGAAC
CGTTTTGACGGTATTATCGAATTCAAAGCCCTTGAAAAAGAAAATCTCCTTACTATTGTTGATCTCATGCTCAAAGATGT
CAATGATAGACTTGCTACCAACGGTCTTCACCTTGATGTCACCGAGAAAGTTAAGGAAAAATTGGTTGATCTTGGCTATG
ATCCAAAAATGGGAGCTCGTCCACTTCGCAGAACAATTCAAGACCATATCGAAGATGCTATCACAGATTTCTATCTTGAA
AATCCTTCAGAGAAAAATCTCCGTGCCATCATGACTTCTAATGGAAACATCATTATCAAATCAAATACGAAAGCTGAAGC
TGTCGTAGAAGAAAACTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (651-726)

• AAA domain (Cdc48 subfamily) (AAA_2) (480-643)

• AAA lid domain (AAA_lid_9) (295-392)

• ATPase family associated with various cellular activities (AAA) (AAA) (157-276)

3D structure

• AlphaFold DB: A0A345VLJ9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	86.418	99.867	0.863
clpE	Streptococcus pneumoniae Rx1	82.649	100	0.83
clpE	Streptococcus pneumoniae D39	82.649	100	0.83
clpE	Streptococcus pneumoniae R6	82.649	100	0.83
clpE	Streptococcus pneumoniae TIGR4	82.649	100	0.83
clpC	Lactococcus lactis subsp. cremoris KW2	75.6	99.734	0.754
clpC	Bacillus subtilis subsp. subtilis str. 168	50.297	89.628	0.451
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.625	84.707	0.395
clpC	Streptococcus pneumoniae Rx1	47.581	82.447	0.392
clpC	Streptococcus pneumoniae D39	47.581	82.447	0.392
clpC	Streptococcus pneumoniae TIGR4	47.419	82.447	0.391
clpC	Streptococcus mutans UA159	47.182	82.58	0.39
clpC	Streptococcus thermophilus LMD-9	46.057	84.309	0.388
clpC	Streptococcus thermophilus LMG 18311	45.741	84.309	0.386