Detailed information NTG0241034

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: Sp14A_RS00930
• Genome accession: NZ_CP022601
• Coordinates: 153726..156164 (+)
• Length: 812 a.a.
• NCBI ID: WP_115129565.1
• Uniprot ID: A0A345VHE0
• Organism: Streptococcus pluranimalium strain 14A0014
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 148726..161164

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Sp14A_RS00915 (Sp14A_01850)	rpsB	151037..151798 (+)	762	WP_104967140.1	30S ribosomal protein S2	-
Sp14A_RS00920 (Sp14A_01860)	tsf	152030..153070 (+)	1041	WP_115129564.1	translation elongation factor Ts	-
Sp14A_RS00925 (Sp14A_01870)	-	153265..153726 (+)	462	WP_104967142.1	CtsR family transcriptional regulator	-
Sp14A_RS00930 (Sp14A_01880)	clpC	153726..156164 (+)	2439	WP_115129565.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
Sp14A_RS00935 (Sp14A_01890)	-	156389..157060 (+)	672	WP_115129566.1	response regulator transcription factor	-
Sp14A_RS00940 (Sp14A_01900)	-	157062..158423 (+)	1362	WP_115129567.1	HAMP domain-containing sensor histidine kinase	-
Sp14A_RS00945 (Sp14A_01910)	-	158597..159313 (+)	717	WP_115129568.1	CPBP family glutamic-type intramembrane protease	-
Sp14A_RS00950 (Sp14A_01920)	-	159387..160145 (+)	759	WP_162797748.1	PrsW family glutamic-type intramembrane protease	-

Sequence

Protein

• Length: 812 a.a.
• Molecular weight: 90133.27 Da
• Isoelectric Point: 5.4949

>NTDB_id=241034 Sp14A_RS00930 WP_115129565.1 153726..156164(+) (clpC) [Streptococcus pluranimalium strain 14A0014]
MVKYSQKMQDVFGLSQIIATRFSCQLLESWHLLLGLISSDETIAGLTFREFDSETGENDYFAAAILASEKTFDDSINHFD
FHEQSVATADMLAFAEQISLITGDDEVGTEHVLMAMLLSPDRMPIRVLELAGFKLKNDGEGASIFSIRQGLEKHAGFTKD
QVKAIHELKKPKRPKANNFTDMMKPPSTAGELSDFTRDLTAMAEAGALEAVVGRDKEVSRMVQVLSRKTKNNPVLVGDAG
VGKTALAYGLAQRIASGEIPYELRDMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGHIILFVDEMHTIMGSGSGI
DSTLDAANILKPALSRGSLHMVGATTQEEYQKHIEKDAALSRRFAKIIIEEPSVADAFEILKGLRPSYEAYHHVSLSDEA
LVTAVKSAHRYMTSKNLPDSAIDLMDEASATVQTMVKKEAQVELSPIDEALLDGDFKAVSRLLKKEEKVSLPKVIKVTEE
HIMSTLSRLTGIPVEKMTQADNQKYLNLEKELHKRVIGQDTAISAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKTEL
AKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRQKPYSVLLFDEVEKAHPDIFNVLLQVL
DDGMLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVQDLSHDHDAMEKRILEELKKAYRPEFINRIDEKVVFHSL
TQDHMREVVKIMVQPLIKQLAEKGIVLKFQPSALKHLAEDGYDIEMGARPLRRTIQTQVEDHLAELVLSGQLATGNTLKV
GVKQGKLKFDVV

Nucleotide

• Length: 2439 bp

>NTDB_id=241034 Sp14A_RS00930 WP_115129565.1 153726..156164(+) (clpC) [Streptococcus pluranimalium strain 14A0014]
ATGGTTAAGTATTCACAAAAAATGCAGGATGTTTTTGGCCTGTCCCAAATTATTGCTACACGATTTTCTTGTCAGCTCTT
AGAAAGTTGGCATCTTTTACTTGGATTGATTTCTAGTGATGAAACGATTGCAGGGTTGACTTTCCGAGAATTCGATAGCG
AAACTGGTGAGAATGATTATTTTGCAGCAGCTATTTTAGCGTCAGAAAAGACTTTTGATGATAGTATCAATCACTTTGAT
TTTCATGAACAATCAGTTGCAACGGCTGATATGTTGGCTTTTGCGGAGCAGATTAGTCTTATTACTGGAGATGATGAAGT
CGGTACGGAGCATGTTCTCATGGCTATGCTTTTGAGTCCTGACAGGATGCCTATCCGTGTCCTTGAGTTAGCTGGTTTCA
AATTAAAAAATGATGGCGAAGGTGCTTCAATTTTTAGTATTCGCCAAGGTTTAGAGAAGCATGCTGGTTTTACGAAAGAC
CAAGTCAAGGCCATTCATGAATTGAAAAAACCAAAACGTCCTAAAGCGAACAATTTTACAGATATGATGAAACCACCGTC
AACTGCAGGCGAGTTATCGGATTTTACTCGCGATTTGACAGCCATGGCGGAAGCTGGAGCTCTCGAAGCAGTTGTTGGTC
GTGACAAAGAAGTCTCTCGCATGGTACAGGTGCTTAGCCGTAAAACCAAGAATAACCCAGTCTTAGTTGGTGATGCTGGT
GTTGGTAAAACTGCCCTAGCTTATGGATTAGCACAACGTATTGCGAGCGGTGAGATTCCTTATGAGTTACGTGATATGCG
TGTTCTTGAACTAGACATGATGAGTGTAGTTGCGGGAACGCGTTTCCGTGGTGACTTTGAAGAGCGTATGAACCAAATTA
TTGATGATATCGAAGCCGATGGTCATATCATTCTTTTTGTGGATGAGATGCATACTATCATGGGTTCTGGTAGTGGGATT
GATAGTACGCTTGATGCAGCTAATATCCTAAAACCTGCTCTTTCTCGTGGAAGCCTCCACATGGTTGGGGCTACAACACA
AGAAGAGTACCAAAAACACATCGAAAAGGACGCTGCCTTGTCACGTCGCTTTGCTAAAATTATTATTGAAGAGCCATCAG
TTGCAGATGCTTTTGAAATTTTGAAAGGCTTACGTCCAAGTTATGAAGCCTATCATCATGTGTCACTATCAGATGAAGCT
TTGGTGACAGCGGTTAAGTCTGCTCACCGTTACATGACCAGTAAAAACCTACCTGATTCAGCTATCGATTTAATGGATGA
AGCCAGTGCCACGGTTCAGACCATGGTTAAAAAAGAAGCGCAAGTAGAACTGTCGCCTATTGATGAAGCACTTTTAGATG
GTGATTTTAAAGCTGTCTCTCGTTTGCTTAAGAAGGAAGAGAAGGTGTCTCTTCCAAAAGTTATCAAGGTAACCGAAGAG
CACATCATGTCTACCCTCAGTCGTCTGACAGGAATTCCTGTGGAAAAAATGACACAGGCTGACAATCAGAAGTATCTCAA
TTTGGAAAAAGAGTTGCATAAGCGTGTGATTGGACAAGATACGGCGATTTCGGCGATTAGTCGGGCAATTCGTCGTAATC
AGTCGGGCATTAGGACTGGTAAACGTCCTATCGGATCTTTCATGTTCTTGGGACCAACTGGAGTTGGTAAGACGGAGTTG
GCTAAGGCCTTGGCGGAAGTCCTTTTTGATGATGAATCAGCCCTCATTCGTTTTGACATGTCTGAGTATATGGAAAAATT
TGCCGCCTCACGTCTTAACGGTGCTCCTCCGGGTTATGTCGGCTACGATGAAGGGGGAGAATTAACAGAGAAAGTTCGTC
AGAAACCTTATTCTGTCCTCTTATTTGATGAGGTTGAAAAGGCACATCCAGATATTTTCAATGTTCTTTTGCAAGTGCTG
GATGATGGAATGTTGACTGATAGTCGTGGACGCAAAGTGGATTTTTCAAATACGATTATCATCATGACGTCAAATCTTGG
TGCTACAGCTCTTCGTGATGATAAGACTGTTGGCTTTGGTGTTCAGGATCTCTCACATGACCATGATGCTATGGAAAAAC
GTATTTTGGAAGAGCTTAAAAAAGCTTATCGTCCTGAATTTATCAACCGTATTGATGAGAAAGTTGTCTTCCACAGCTTA
ACACAAGATCACATGAGAGAAGTCGTTAAGATTATGGTTCAACCGTTAATCAAGCAGTTAGCTGAGAAAGGTATTGTCTT
AAAATTCCAACCATCAGCTCTTAAACACTTGGCTGAAGATGGTTACGATATCGAAATGGGAGCTCGCCCACTTCGTCGCA
CCATTCAAACCCAAGTCGAAGACCACCTAGCAGAATTAGTTCTTTCAGGACAATTAGCCACAGGCAATACCCTCAAGGTT
GGTGTCAAACAAGGTAAGCTTAAGTTTGATGTGGTTTGA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (720-800)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (22-50)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-136)

• ATPase family associated with various cellular activities (AAA) (AAA) (234-368)

• AAA lid domain (AAA_lid_9) (373-445)

• AAA domain (Cdc48 subfamily) (AAA_2) (542-713)

3D structure

• AlphaFold DB: A0A345VHE0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	71.71	100	0.718
clpC	Streptococcus thermophilus LMG 18311	71.078	100	0.714
clpC	Streptococcus thermophilus LMD-9	70.956	100	0.713
clpC	Streptococcus pneumoniae Rx1	65.314	100	0.654
clpC	Streptococcus pneumoniae TIGR4	65.314	100	0.654
clpC	Streptococcus pneumoniae D39	65.314	100	0.654
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.268	100	0.498
clpC	Bacillus subtilis subsp. subtilis str. 168	44.753	100	0.457