Detailed information NTG0241024

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: Sp14A_RS00410
• Genome accession: NZ_CP022601
• Coordinates: 69884..70792 (+)
• Length: 302 a.a.
• NCBI ID: WP_115129515.1
• Uniprot ID: A0A345VH54
• Organism: Streptococcus pluranimalium strain 14A0014
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 64884..75792

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Sp14A_RS00380 (Sp14A_00770)	purE	64895..65383 (+)	489	WP_115129509.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
Sp14A_RS00385 (Sp14A_00780)	purK	65370..66437 (+)	1068	WP_115129510.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
Sp14A_RS00390 (Sp14A_00790)	-	66514..67146 (+)	633	WP_115129511.1	YdcF family protein	-
Sp14A_RS00395 (Sp14A_00800)	-	67449..67688 (+)	240	WP_115129512.1	phosphoribosylaminoimidazole carboxylase	-
Sp14A_RS00400 (Sp14A_00810)	-	67682..68428 (+)	747	WP_115129513.1	hypothetical protein	-
Sp14A_RS00405 (Sp14A_00820)	purB	68452..69744 (+)	1293	WP_115129514.1	adenylosuccinate lyase	-
Sp14A_RS00410 (Sp14A_00830)	comR	69884..70792 (+)	909	WP_115129515.1	XRE family transcriptional regulator	Regulator
Sp14A_RS00415 (Sp14A_00850)	-	71184..71606 (+)	423	WP_115129516.1	low molecular weight protein-tyrosine-phosphatase	-
Sp14A_RS00420 (Sp14A_00860)	-	71625..72026 (+)	402	WP_115129517.1	hypothetical protein	-
Sp14A_RS00425 (Sp14A_00870)	-	72023..73804 (+)	1782	WP_115129518.1	acyltransferase family protein	-
Sp14A_RS00430 (Sp14A_00880)	-	74037..74393 (+)	357	WP_115129519.1	GntR family transcriptional regulator	-
Sp14A_RS00435 (Sp14A_00890)	-	74386..75213 (+)	828	WP_115129520.1	ATP-binding cassette domain-containing protein	-

Sequence

Protein

• Length: 302 a.a.
• Molecular weight: 35624.85 Da
• Isoelectric Point: 4.6700

>NTDB_id=241024 Sp14A_RS00410 WP_115129515.1 69884..70792(+) (comR) [Streptococcus pluranimalium strain 14A0014]
MFADFGSRLKELRNERNLTREAFCMDEAELSVRQLARIELGESLPNIKTAMFIAQRLGVSLQFLTNGENLALPKEYLDLK
HHILRVPTYSDIKRITIKENYFDEIYEKYYDSLPEVEKLVIDTLQATQDSLITENINFGLSILGDYFEQTKLKAAYDEND
LILINLYLTYLDLVGLEGEYSDPVFNSRLFDHLVRQSVHYTTDELIVLTQVLISLYAITLKDNRLVKLEMVLQMIDYTMQ
KTQDFSRLPIQKILEWKYRLYIEQDQDSAKHSYDKAMLFAQMTDDSYLEEKLRVEWNKDMKK

Nucleotide

• Length: 909 bp

>NTDB_id=241024 Sp14A_RS00410 WP_115129515.1 69884..70792(+) (comR) [Streptococcus pluranimalium strain 14A0014]
ATGTTTGCAGACTTTGGTTCACGATTGAAAGAATTAAGAAATGAAAGAAATCTAACTAGAGAAGCTTTTTGTATGGATGA
AGCCGAATTATCTGTAAGACAATTAGCTCGCATTGAATTAGGTGAGTCACTACCTAATATTAAGACAGCTATGTTTATTG
CACAACGTTTGGGAGTATCATTACAATTTTTAACGAATGGTGAAAATTTAGCGTTACCAAAAGAGTACTTAGATTTAAAA
CACCATATTTTAAGAGTACCGACTTACTCTGATATTAAAAGGATAACTATCAAAGAAAATTATTTTGATGAAATATATGA
AAAATACTACGATAGTTTACCAGAAGTAGAAAAATTGGTTATTGATACTTTACAAGCAACTCAGGATTCACTCATTACGG
AAAATATTAATTTTGGACTTAGTATTTTGGGGGATTATTTTGAGCAGACAAAACTAAAAGCGGCTTATGATGAGAATGAT
TTGATTTTAATAAATTTGTATCTTACTTATCTGGATTTAGTAGGTTTAGAAGGTGAGTATTCTGACCCAGTATTTAATAG
TCGCTTATTTGATCATTTGGTTAGACAGTCTGTACACTATACAACAGATGAATTAATAGTATTAACTCAGGTTCTAATTA
GCCTGTATGCTATAACATTGAAAGATAATCGACTAGTGAAATTAGAAATGGTTTTGCAAATGATTGATTATACAATGCAA
AAAACTCAGGATTTTAGTAGATTACCCATTCAGAAAATTTTGGAATGGAAGTACAGGCTGTATATTGAACAGGATCAAGA
TAGTGCCAAACATAGTTATGATAAAGCCATGCTATTTGCTCAAATGACGGACGATAGCTATTTGGAAGAAAAATTAAGAG
TTGAATGGAATAAAGATATGAAAAAATGA

Domains

Predicted by InterproScan.

• Helix-turn-helix domain (HTH_19) (6-69)

• ComR tetratricopeptide (ComR_TPR) (73-296)

3D structure

• AlphaFold DB: A0A345VH54

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	50.166	99.669	0.5
comR	Streptococcus mutans UA159	45.695	100	0.457
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	44.483	96.026	0.427
comR	Streptococcus pyogenes MGAS315	40.461	100	0.407
comR	Streptococcus suis P1/7	37.919	98.675	0.374
comR	Streptococcus suis 05ZYH33	37.919	98.675	0.374