Detailed information NTG0240595

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: CG712_RS07655
• Genome accession: NZ_CP022547
• Coordinates: 1445190..1446707 (+)
• Length: 505 a.a.
• NCBI ID: WP_002949640.1
• Uniprot ID: A0A060BQ50
• Organism: Streptococcus thermophilus strain B59671
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 1440190..1451707

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CG712_RS10465 (CG712_07690)	-	1440469..1440639 (+)	171	Protein_1432	ascorbate 6-phosphate lactonase	-
CG712_RS07630 (CG712_07695)	-	1440656..1441327 (-)	672	WP_002946492.1	potassium channel family protein	-
CG712_RS07635 (CG712_07700)	-	1441367..1442731 (-)	1365	WP_014727321.1	TrkH family potassium uptake protein	-
CG712_RS07640 (CG712_07705)	rsmG	1442801..1443514 (-)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
CG712_RS07645 (CG712_07710)	-	1443811..1444347 (+)	537	WP_002946488.1	DUF177 domain-containing protein	-
CG712_RS07650 (CG712_07715)	covR	1444504..1445193 (+)	690	WP_002949638.1	response regulator transcription factor	Regulator
CG712_RS07655 (CG712_07720)	covS	1445190..1446707 (+)	1518	WP_002949640.1	HAMP domain-containing histidine kinase	Regulator
CG712_RS07660 (CG712_07725)	nrdR	1446829..1447308 (+)	480	WP_002949642.1	transcriptional regulator NrdR	-
CG712_RS07665 (CG712_07730)	-	1447305..1448480 (+)	1176	WP_002949643.1	DnaD domain protein	-
CG712_RS07670 (CG712_07735)	dnaI	1448484..1449386 (+)	903	WP_002946786.1	primosomal protein DnaI	-
CG712_RS07675 (CG712_07740)	der	1449492..1450802 (+)	1311	WP_002946789.1	ribosome biogenesis GTPase Der	-

Sequence

Protein

• Length: 505 a.a.
• Molecular weight: 57536.93 Da
• Isoelectric Point: 5.2689

>NTDB_id=240595 CG712_RS07655 WP_002949640.1 1445190..1446707(+) (covS) [Streptococcus thermophilus strain B59671]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide

• Length: 1518 bp

>NTDB_id=240595 CG712_RS07655 WP_002949640.1 1445190..1446707(+) (covS) [Streptococcus thermophilus strain B59671]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTTACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAATCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGATAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (384-494)

• ArlS sensor domain (ArlS_N) (39-187)

• His Kinase A (phospho-acceptor) domain (HisKA) (270-329)

• HAMP domain (HAMP) (213-265)

3D structure

• AlphaFold DB: A0A060BQ50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Streptococcus salivarius strain HSISS4	94.622	99.406	0.941