Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   CGZ53_RS06455 Genome accession   NZ_CP022435
Coordinates   1267197..1269467 (+) Length   756 a.a.
NCBI ID   WP_046390636.1    Uniprot ID   -
Organism   Streptococcus uberis strain NZ01     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1262197..1274467
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CGZ53_RS06425 (CGZ53_06420) - 1262532..1262747 (-) 216 WP_100912149.1 exodeoxyribonuclease VII small subunit -
  CGZ53_RS06430 (CGZ53_06425) xseA 1262737..1264065 (-) 1329 WP_100912150.1 exodeoxyribonuclease VII large subunit -
  CGZ53_RS06435 (CGZ53_06430) - 1264207..1265061 (-) 855 WP_100912151.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  CGZ53_RS06440 (CGZ53_06435) - 1265165..1265899 (-) 735 WP_012658752.1 amino acid ABC transporter ATP-binding protein -
  CGZ53_RS06445 (CGZ53_06440) - 1265896..1266585 (-) 690 WP_012658753.1 amino acid ABC transporter permease -
  CGZ53_RS06450 (CGZ53_06445) - 1266712..1266942 (-) 231 WP_012658754.1 DUF1797 family protein -
  CGZ53_RS06455 (CGZ53_06450) clpE 1267197..1269467 (+) 2271 WP_046390636.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  CGZ53_RS06460 (CGZ53_06455) - 1269601..1270056 (+) 456 WP_100912152.1 NUDIX hydrolase -
  CGZ53_RS06465 (CGZ53_06460) - 1270108..1270419 (+) 312 WP_037591782.1 DUF1827 family protein -
  CGZ53_RS06470 (CGZ53_06465) ileS 1270522..1273317 (-) 2796 WP_046388236.1 isoleucine--tRNA ligase -
  CGZ53_RS06475 (CGZ53_06470) - 1273570..1274334 (-) 765 WP_046388237.1 DivIVA domain-containing protein -

Sequence

Protein


Download         Length: 756 a.a.        Molecular weight: 84131.36 Da        Isoelectric Point: 5.2145

>NTDB_id=239389 CGZ53_RS06455 WP_046390636.1 1267197..1269467(+) (clpE) [Streptococcus uberis strain NZ01]
MLCQNCKLNEATIHLYTNVNGKQRQVDLCQNCYQIMKTDTNNPILGGQNGKPQQDSINPFFDDFFGDLNNFRAFGQLPNT
PPTQSGGGQGNGGHRGGHNGSQAQAAQTQKPNGLLEEFGINVTDIARRGDIDPVIGRDDEIVRVIEILNRRTKNNPVLIG
EPGVGKTAVVEGLAQKIVDGDVPHKLQHKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRQDVILFIDEIHEIVGAG
SAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQSKYEDYHHVKYSQ
DAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLVEAENLKAQATRDEDFERAAYFRDQIAKYK
ELQKQKVDDEDTPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLSDDLKAHVIGQDDAVEKIAKAIRRNRVGLGSPNR
PIGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILL
DEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGRVEASVGFGAAREGRTNSVLGELSNYFSPEFMN
RFDGIIEFQPLSKENLLHIVDLMLEDVNARLSHNNIHLEVTAKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDFYLE
NPTEKNLKAMMSSNGNILIKAIKAKSSEEPLDMPVK

Nucleotide


Download         Length: 2271 bp        

>NTDB_id=239389 CGZ53_RS06455 WP_046390636.1 1267197..1269467(+) (clpE) [Streptococcus uberis strain NZ01]
ATGCTTTGTCAAAATTGTAAATTAAATGAAGCAACTATTCATCTATATACGAATGTGAATGGAAAACAAAGACAGGTAGA
TCTTTGTCAAAATTGTTATCAAATCATGAAAACAGATACTAATAATCCTATCCTAGGTGGTCAAAATGGGAAACCACAAC
AAGATTCGATAAACCCATTCTTTGATGACTTTTTTGGTGATCTCAACAATTTCAGGGCATTTGGTCAATTGCCAAACACG
CCACCGACTCAATCTGGAGGCGGACAAGGTAATGGGGGACACCGTGGAGGACACAACGGGTCACAGGCTCAAGCTGCTCA
AACGCAAAAACCAAATGGCCTTTTAGAAGAATTCGGTATCAATGTAACTGATATTGCCAGAAGAGGTGATATTGATCCTG
TTATCGGACGCGATGATGAAATTGTTCGCGTCATTGAAATTCTAAATCGACGGACTAAAAATAACCCTGTCCTTATTGGG
GAACCTGGTGTTGGTAAAACTGCAGTGGTGGAGGGTTTAGCTCAAAAAATTGTAGATGGGGATGTTCCACATAAATTACA
ACACAAACAAGTCATTCGATTAGATGTAGTCAGTTTAGTTCAAGGAACTGGCATTCGTGGTCAGTTCGAAGAACGCATGC
AAAAACTAATGGAAGAAATCCGAAATCGCCAAGATGTCATTTTATTTATTGACGAAATTCATGAGATTGTCGGTGCTGGT
AGTGCAGGCGATGGCAATATGGATGCTGGTAACATTTTAAAACCTGCCCTTGCTCGTGGAGAATTACAACTGGTTGGTGC
AACGACGTTGAATGAATATCGGATCATTGAAAAAGATGCTGCACTTGAAAGACGTATGCAGCCAGTTAAAGTTGATGAAC
CTTCAGTTGAGGAAACCATCACTATTTTAAAAGGGATTCAAAGCAAATATGAAGATTACCATCATGTGAAATACAGTCAA
GATGCTATCGAAGCTGCTGCTCACCTTTCTAATAGGTATATTCAGGATCGTTTCCTTCCCGATAAAGCCATTGATTTGCT
CGACGAAGCCGGTTCTAAAATGAACTTGACATTAAACTTTGTTGATCCCAAAGAGATTGATAAGAGATTAGTCGAAGCTG
AAAACTTAAAAGCGCAAGCCACTAGGGATGAAGATTTTGAACGCGCAGCTTACTTCAGAGACCAAATTGCAAAATACAAA
GAATTGCAAAAACAAAAGGTAGACGACGAAGACACTCCTATTATCACAGAAAAAACAATTGAAGCCATTGTTGAACAAAA
AACCAATATTCCAGTTGGCGATTTAAAGGAAAAAGAACAATCCCAATTGGTCAACTTATCAGATGATCTTAAAGCGCATG
TCATCGGTCAAGATGATGCGGTTGAAAAGATTGCAAAAGCTATTCGACGAAATCGTGTCGGACTTGGTAGCCCTAATCGT
CCTATTGGTTCTTTCCTTTTCGTTGGACCGACTGGTGTTGGTAAAACAGAGCTTTCTAAGCAATTGGCTATTGAACTTTT
TGGATCTGCTGATAATATGATTCGATTTGACATGTCGGAATACATGGAAAAACATGCTGTTGCTAAATTGGTAGGAGCGC
CTCCAGGATATGTTGGTTATGAGGAAGCTGGTCAGCTGACAGAAAAAGTTAGACGGAACCCATACTCACTTATACTTCTG
GATGAAGTTGAGAAGGCTCATCCTGATGTGATGCATATGTTCTTACAAGTTTTGGATGATGGTCGCTTAACGGATGGACA
AGGTCGAACTGTGAGCTTTAAGGACACTATTATCATCATGACTTCAAATGCGGGAACAGGACGCGTTGAAGCTTCAGTTG
GTTTTGGTGCAGCGCGTGAAGGACGTACAAACTCTGTTTTAGGCGAATTAAGTAACTACTTTAGTCCAGAATTTATGAAC
CGTTTTGATGGTATCATTGAATTCCAACCATTAAGTAAAGAAAACTTACTCCACATTGTAGATTTAATGTTGGAAGATGT
TAATGCTCGCTTATCTCATAACAATATTCATCTTGAAGTAACAGCTAAGGTTAAAGAAAAATTGGTTGATCTTGGCTATG
ACCCTAAAATGGGGGCCCGTCCTCTAAGAAGGACCATTCAAGAGCATATCGAAGATGCTATTACAGATTTCTACTTAGAA
AATCCAACAGAAAAAAATCTCAAAGCTATGATGTCAAGTAATGGGAATATTCTTATTAAAGCCATTAAAGCGAAATCAAG
TGAAGAACCGCTTGATATGCCAGTTAAATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(651-726)

AAA lid domain (AAA_lid_9)

(295-392)

AAA domain (Cdc48 subfamily) (AAA_2)

(480-643)

ATPase family associated with various cellular activities (AAA) (AAA)

(157-276)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

86.711

98.545

0.854
  clpE Streptococcus pneumoniae Rx1

83.511

99.471

0.831
  clpE Streptococcus pneumoniae D39

83.511

99.471

0.831
  clpE Streptococcus pneumoniae R6

83.511

99.471

0.831
  clpE Streptococcus pneumoniae TIGR4

83.378

99.471

0.829
  clpC Lactococcus lactis subsp. cremoris KW2

77.596

96.825

0.751
  clpC Bacillus subtilis subsp. subtilis str. 168

52.426

84.524

0.443
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.851

86.111

0.403
  clpC Streptococcus pneumoniae TIGR4

48.71

82.011

0.399
  clpC Streptococcus pneumoniae Rx1

48.71

82.011

0.399
  clpC Streptococcus pneumoniae D39

48.71

82.011

0.399
  clpC Streptococcus mutans UA159

47.981

81.878

0.393
  clpC Streptococcus thermophilus LMD-9

46.785

82.275

0.385
  clpC Streptococcus thermophilus LMG 18311

46.463

82.275

0.382

Multiple sequence alignment