Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   QMA0248_RS09555 Genome accession   NZ_CP022392
Coordinates   1985606..1988053 (-) Length   815 a.a.
NCBI ID   WP_003100371.1    Uniprot ID   -
Organism   Streptococcus iniae strain QMA0248     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1980600..2022494 1985606..1988053 within 0


Gene organization within MGE regions


Location: 1980600..2022494
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QMA0248_RS09540 (QMA0248_1927) - 1980600..1982924 (-) 2325 WP_232471173.1 hypothetical protein -
  QMA0248_RS10445 (QMA0248_1928) - 1983014..1983343 (-) 330 WP_003100365.1 YSIRK-type signal peptide-containing protein -
  QMA0248_RS09545 (QMA0248_1929) groL 1983514..1985142 (-) 1629 WP_003100367.1 chaperonin GroEL -
  QMA0248_RS09550 (QMA0248_1930) groES 1985174..1985464 (-) 291 WP_003100369.1 co-chaperone GroES -
  QMA0248_RS09555 (QMA0248_1931) clpC 1985606..1988053 (-) 2448 WP_003100371.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  QMA0248_RS09560 (QMA0248_1932) - 1988056..1988514 (-) 459 WP_003100373.1 CtsR family transcriptional regulator -
  QMA0248_RS09565 (QMA0248_1933) - 1988685..1988888 (-) 204 WP_016356203.1 cold-shock protein -
  QMA0248_RS09570 (QMA0248_1934) - 1989172..1989438 (+) 267 WP_003100378.1 hypothetical protein -
  QMA0248_RS09575 (QMA0248_1935) - 1989442..1991505 (+) 2064 WP_003100380.1 cation:proton antiporter -
  QMA0248_RS09580 (QMA0248_1936) - 1991713..1992783 (-) 1071 WP_016356204.1 tyrosine-type recombinase/integrase -
  QMA0248_RS09585 (QMA0248_1937) - 1992912..1993469 (-) 558 WP_016356205.1 hypothetical protein -
  QMA0248_RS09590 (QMA0248_1938) - 1993491..1993868 (-) 378 WP_121791665.1 ImmA/IrrE family metallo-endopeptidase -
  QMA0248_RS09595 (QMA0248_1939) - 1993887..1994246 (-) 360 WP_016356207.1 helix-turn-helix domain-containing protein -
  QMA0248_RS09600 (QMA0248_1940) - 1994533..1994697 (+) 165 WP_016356208.1 hypothetical protein -
  QMA0248_RS09605 (QMA0248_1941) - 1994680..1995150 (-) 471 WP_016356209.1 hypothetical protein -
  QMA0248_RS09610 (QMA0248_1942) - 1995213..1995425 (+) 213 WP_016356210.1 helix-turn-helix domain-containing protein -
  QMA0248_RS09615 (QMA0248_1943) - 1995425..1995766 (+) 342 WP_016356211.1 hypothetical protein -
  QMA0248_RS09620 (QMA0248_1944) - 1995809..1996093 (+) 285 WP_071126748.1 DNA-binding protein -
  QMA0248_RS09625 - 1996110..1996295 (+) 186 WP_016356213.1 hypothetical protein -
  QMA0248_RS09630 (QMA0248_1945) dnaB 1996295..1997629 (+) 1335 WP_016356214.1 replicative DNA helicase -
  QMA0248_RS09635 (QMA0248_1946) - 1997631..1998215 (+) 585 WP_016356215.1 hypothetical protein -
  QMA0248_RS09640 (QMA0248_1947) - 1998212..1998973 (+) 762 WP_016356216.1 conserved phage C-terminal domain-containing protein -
  QMA0248_RS09645 (QMA0248_1948) - 1998974..1999786 (+) 813 WP_016356217.1 ATP-binding protein -
  QMA0248_RS09650 (QMA0248_1949) - 1999786..2000247 (+) 462 WP_016356218.1 class I SAM-dependent methyltransferase -
  QMA0248_RS09655 (QMA0248_1950) - 2000257..2000502 (+) 246 WP_016356219.1 hypothetical protein -
  QMA0248_RS10505 (QMA0248_1951) - 2000517..2000648 (+) 132 WP_016356220.1 hypothetical protein -
  QMA0248_RS09660 (QMA0248_1953) - 2000791..2001018 (+) 228 WP_016356222.1 hypothetical protein -
  QMA0248_RS09665 (QMA0248_1954) - 2001021..2001224 (+) 204 WP_016356223.1 hypothetical protein -
  QMA0248_RS09670 (QMA0248_1955) - 2001214..2001834 (+) 621 WP_016356224.1 DUF1642 domain-containing protein -
  QMA0248_RS09675 (QMA0248_1956) - 2001836..2002210 (+) 375 WP_198362314.1 hypothetical protein -
  QMA0248_RS09680 (QMA0248_1957) - 2002211..2002429 (+) 219 WP_089180115.1 hypothetical protein -
  QMA0248_RS09685 (QMA0248_1958) - 2002431..2002832 (+) 402 WP_016356226.1 hypothetical protein -
  QMA0248_RS09690 (QMA0248_1959) - 2002852..2003370 (+) 519 WP_016356227.1 hypothetical protein -
  QMA0248_RS09695 (QMA0248_1960) - 2003367..2003678 (+) 312 WP_016356228.1 helix-turn-helix domain-containing protein -
  QMA0248_RS10370 (QMA0248_1961) - 2003689..2003838 (+) 150 WP_016356229.1 hypothetical protein -
  QMA0248_RS09700 (QMA0248_1962) - 2004021..2004416 (+) 396 WP_225111326.1 transcriptional regulator -
  QMA0248_RS09705 (QMA0248_1963) - 2004602..2005144 (+) 543 WP_016356231.1 site-specific integrase -
  QMA0248_RS09710 (QMA0248_1964) - 2005309..2005494 (+) 186 WP_016356232.1 hypothetical protein -
  QMA0248_RS09715 (QMA0248_1965) - 2005609..2005938 (+) 330 WP_016356233.1 HNH endonuclease -
  QMA0248_RS09720 (QMA0248_1966) - 2006049..2006438 (+) 390 WP_016356234.1 P27 family phage terminase small subunit -
  QMA0248_RS09725 (QMA0248_1967) - 2006476..2008206 (+) 1731 WP_071126782.1 terminase large subunit -
  QMA0248_RS09730 (QMA0248_1968) - 2008229..2009431 (+) 1203 WP_016356236.1 phage portal protein -
  QMA0248_RS09735 (QMA0248_1969) - 2009418..2009996 (+) 579 WP_016356237.1 HK97 family phage prohead protease -
  QMA0248_RS09740 (QMA0248_1970) - 2009993..2011162 (+) 1170 WP_016356238.1 phage major capsid protein -
  QMA0248_RS09745 (QMA0248_1971) - 2011174..2011470 (+) 297 WP_016356239.1 hypothetical protein -
  QMA0248_RS09750 (QMA0248_1972) - 2011473..2011751 (+) 279 WP_016356240.1 hypothetical protein -
  QMA0248_RS09755 (QMA0248_1973) - 2011741..2012040 (+) 300 WP_016356241.1 phage head closure protein -
  QMA0248_RS09760 (QMA0248_1974) - 2012037..2012384 (+) 348 WP_016356242.1 HK97 gp10 family phage protein -
  QMA0248_RS09765 (QMA0248_1975) - 2012381..2012704 (+) 324 WP_016356243.1 hypothetical protein -
  QMA0248_RS09770 (QMA0248_1976) - 2012719..2013303 (+) 585 WP_016356244.1 major tail protein -
  QMA0248_RS09775 (QMA0248_1977) - 2013316..2013735 (+) 420 WP_016356245.1 hypothetical protein -
  QMA0248_RS09780 (QMA0248_1978) - 2014010..2016814 (+) 2805 WP_016356246.1 phage tail tape measure protein -
  QMA0248_RS09785 (QMA0248_1979) - 2016811..2017527 (+) 717 WP_016356247.1 prophage protein -
  QMA0248_RS09790 (QMA0248_1980) - 2017527..2018882 (+) 1356 WP_016356248.1 phage tail spike protein -
  QMA0248_RS09795 (QMA0248_1981) - 2018882..2020426 (+) 1545 WP_016356249.1 hypothetical protein -
  QMA0248_RS09800 (QMA0248_1982) - 2020485..2020706 (+) 222 WP_071126781.1 hypothetical protein -
  QMA0248_RS09805 (QMA0248_1983) - 2020708..2020968 (+) 261 WP_016356251.1 phage holin -
  QMA0248_RS09810 (QMA0248_1985) - 2021082..2022494 (+) 1413 WP_071126739.1 peptidoglycan amidohydrolase family protein -

Sequence

Protein


Download         Length: 815 a.a.        Molecular weight: 90326.91 Da        Isoelectric Point: 6.6034

>NTDB_id=239017 QMA0248_RS09555 WP_003100371.1 1985606..1988053(-) (clpC) [Streptococcus iniae strain QMA0248]
MINYSNKMQEIFKHAQFQAARFESHYLETWHILLAMVAVENSLAGLVFSEFESKIAVEEYEAAAILAMGKSPKESVRGFE
LKLQSKSLEHILNFANAISQVTNEKEVGSEHVLFAILLNPDIMASRVLELAGYKMKDDGSGEPRLVDLRKAIEIHAAYSK
ETIKAIYELRKPKKAKAGGSFSEMMKPPSTAGDLSDFTRDLTELAHQGLLEPVIGREKEISRMVQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIATGAIPYELQEMRVLELDMMSVVAGTRFRGDFEERMNQIIADIEEDGHIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKVLIEEPNLEDAYAIISGLKSSYEQFHNVLISD
EAARASVKLAHRYLTSKQLPDSAIDLLDEASATVQGMVKKDPPSPLNAIDKAIIEGDFKAVSKLLKQDKPSPKLKPTPVT
EAHILKTLSQLSGIPVEKLSQADSKKYLNLEKELHKRVIGQEDAVSAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGMLTDSRGRRVDFSNTIIIMTSNLGATALRDDKTVGFGAKAISHDHTAMEKRILEELKKAYKPEFINRIDEKVVFH
SLSQEDMRQVVMIMVQPLINTLAEKRISLKLQPSALKYLSEKGYDVEMGARPLRRTLQTEIEDKLSELILSGQLSAGHAL
KIGMSQGKLKYDISS

Nucleotide


Download         Length: 2448 bp        

>NTDB_id=239017 QMA0248_RS09555 WP_003100371.1 1985606..1988053(-) (clpC) [Streptococcus iniae strain QMA0248]
ATGATCAATTATTCCAATAAAATGCAGGAGATTTTTAAACATGCTCAATTTCAAGCAGCACGTTTTGAAAGTCATTATTT
AGAAACTTGGCATATATTATTAGCTATGGTAGCTGTTGAAAATTCTTTGGCAGGCCTTGTTTTCAGTGAGTTTGAATCAA
AAATTGCTGTTGAAGAATATGAAGCGGCAGCTATTTTAGCAATGGGCAAAAGCCCTAAGGAATCTGTCAGAGGATTTGAA
CTAAAATTACAGTCAAAGAGTTTGGAACACATCCTAAACTTTGCTAATGCTATTAGTCAGGTAACCAATGAAAAAGAAGT
TGGTTCTGAGCATGTTTTGTTTGCAATTTTATTAAATCCTGACATTATGGCTAGTCGCGTCTTGGAACTAGCAGGTTATA
AAATGAAAGATGATGGCAGCGGTGAGCCACGTTTAGTGGATCTTCGTAAGGCTATTGAAATTCATGCAGCTTATAGTAAA
GAGACCATTAAAGCCATTTATGAATTGCGTAAACCTAAAAAAGCTAAGGCAGGTGGAAGCTTCTCAGAGATGATGAAGCC
GCCTAGCACTGCGGGAGACTTATCAGATTTTACGCGCGATTTAACAGAACTTGCTCATCAAGGCTTGCTTGAGCCAGTTA
TTGGACGTGAAAAAGAGATTTCTCGCATGGTCCAAGTACTTAGCCGTAAAACTAAGAATAATCCTGTTCTTGTTGGAGAT
GCTGGGGTTGGTAAAACAGCTCTTGCCTATGGGCTAGCACAACGCATTGCAACAGGTGCTATTCCGTATGAGTTGCAAGA
AATGCGTGTTTTGGAACTTGATATGATGAGCGTGGTGGCTGGGACGCGTTTTAGAGGTGACTTTGAAGAACGTATGAATC
AAATCATTGCTGATATTGAAGAGGATGGCCATATCATTTTGTTTGTGGATGAACTACACACAATAATGGGTTCAGGAAGT
GGCATTGACAGTACATTAGATGCAGCCAATATCTTAAAACCAGCCCTATCACGTGGGACGCTTCATATGGTTGGCGCAAC
AACCCAAGAAGAATATCAAAAACACATTGAAAAAGATGCAGCTCTCTCAAGACGTTTTGCTAAAGTTTTAATTGAAGAAC
CCAATTTAGAAGATGCTTATGCTATTATTTCAGGGCTTAAATCATCTTATGAGCAATTTCATAATGTGCTTATTTCTGAC
GAGGCGGCTCGCGCTAGTGTTAAGTTAGCCCATCGCTATTTAACCAGCAAGCAGCTTCCAGATTCGGCTATTGATTTATT
AGATGAAGCTAGTGCTACTGTTCAAGGAATGGTAAAAAAAGACCCCCCATCACCTTTAAATGCTATTGATAAGGCAATCA
TAGAAGGTGATTTTAAGGCAGTTTCGAAATTGCTTAAGCAAGATAAGCCTAGTCCTAAATTAAAGCCAACTCCTGTTACA
GAGGCTCATATTCTAAAAACCTTAAGTCAATTATCAGGTATTCCAGTTGAAAAATTAAGTCAAGCAGACAGTAAAAAATA
TTTGAATTTGGAAAAAGAGTTGCATAAGCGTGTTATTGGTCAAGAAGATGCAGTATCAGCTATTTCAAGGGCTATTCGTC
GTAATCAATCAGGAATTAGAACAGGCAAGCGCCCAATTGGTTCCTTCATGTTCCTTGGGCCAACAGGTGTTGGTAAGACA
GAACTTGCCAAAGCCTTAGCTGAAGTCTTATTTGATGATGAGTCTGCCTTAATTCGTTTTGACATGTCTGAATACATGGA
AAAATTTGCGGCAAGCCGTTTAAATGGTGCTCCTCCAGGCTATGTTGGCTATGATGAAGGTGGAGAATTGACCGAAAAAG
TGCGCAACAAACCTTATTCGGTTTTACTCTTTGATGAAGTTGAAAAAGCCCATCCAGATATCTTTAATGTTTTGTTGCAA
GTTTTAGATGATGGGATGTTGACAGATAGTCGTGGTCGTCGTGTTGATTTCTCAAATACCATTATTATCATGACAAGTAA
CCTTGGTGCAACAGCCTTGCGTGATGACAAGACGGTTGGTTTTGGAGCCAAAGCCATTAGCCATGACCATACTGCCATGG
AAAAACGCATTTTAGAAGAACTTAAAAAAGCCTATAAACCAGAATTTATCAATAGAATTGATGAAAAAGTGGTCTTCCAT
AGCTTGAGTCAAGAAGACATGCGTCAAGTGGTTATGATTATGGTGCAGCCATTGATAAATACCTTAGCAGAAAAAAGGAT
CTCCCTCAAACTTCAACCATCGGCCCTTAAGTACCTTTCAGAAAAAGGATATGATGTGGAAATGGGTGCTCGTCCTCTTA
GACGTACCCTCCAGACAGAAATTGAAGATAAATTGTCAGAGCTCATTTTATCAGGTCAGCTCTCAGCTGGTCATGCCTTG
AAAATTGGTATGTCGCAAGGGAAATTAAAATACGATATCTCTTCATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(722-800)

AAA lid domain (AAA_lid_9)

(376-453)

AAA domain (Cdc48 subfamily) (AAA_2)

(544-715)

ATPase family associated with various cellular activities (AAA) (AAA)

(236-368)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(15-51)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(106-132)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus mutans UA159

75.4

99.755

0.752
  clpC Streptococcus thermophilus LMG 18311

70.588

100

0.707
  clpC Streptococcus thermophilus LMD-9

70.588

100

0.707
  clpC Streptococcus pneumoniae Rx1

65.686

100

0.658
  clpC Streptococcus pneumoniae D39

65.686

100

0.658
  clpC Streptococcus pneumoniae TIGR4

65.564

100

0.656
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.321

100

0.494
  clpC Bacillus subtilis subsp. subtilis str. 168

42.548

100

0.434

Multiple sequence alignment