Detailed information NTG0238684

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: B2G65_RS03545
• Genome accession: NZ_CP022354
• Coordinates: 652434..653471 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain GUR
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 647434..658471

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B2G65_RS03520 (B2G65_03520)	-	647698..649029 (+)	1332	WP_032460502.1	dipeptidase	-
B2G65_RS03525 (B2G65_03525)	arcC	649049..649999 (+)	951	WP_010922501.1	carbamate kinase	-
B2G65_RS03530 (B2G65_03530)	asnA	650312..651304 (+)	993	WP_093974619.1	aspartate--ammonia ligase	-
B2G65_RS03535 (B2G65_03535)	rsmD	651427..651966 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
B2G65_RS03540 (B2G65_03540)	coaD	651956..652447 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
B2G65_RS03545 (B2G65_03545)	sepM	652434..653471 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
B2G65_RS03550 (B2G65_03550)	-	653885..654862 (+)	978	WP_063812093.1	LacI family DNA-binding transcriptional regulator	-
B2G65_RS03555 (B2G65_03555)	-	655251..655871 (+)	621	WP_002992791.1	YutD family protein	-
B2G65_RS03560 (B2G65_03560)	rlmN	655875..656954 (+)	1080	WP_093974621.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
B2G65_RS03565 (B2G65_03565)	-	657036..657662 (-)	627	WP_093974623.1	prepilin peptidase	-
B2G65_RS03570 (B2G65_03570)	-	657890..658417 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=238684 B2G65_RS03545 WP_010922499.1 652434..653471(+) (sepM) [Streptococcus pyogenes strain GUR]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=238684 B2G65_RS03545 WP_010922499.1 652434..653471(+) (sepM) [Streptococcus pyogenes strain GUR]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693