Detailed information NTG0238563

Bioinformatically predicted

Overview

• Name: hexB
• Type: Machinery gene
• Locus tag: C9I27_RS09620
• Genome accession: NZ_CP028148
• Coordinates: 1873499..1875481 (-)
• Length: 660 a.a.
• NCBI ID: WP_002991363.1
• Uniprot ID: Q1JJH1
• Organism: Streptococcus pyogenes strain TJ11-001
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1868499..1880481

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C9I27_RS09595	recA	1868535..1869671 (-)	1137	WP_002982186.1	recombinase RecA	Machinery gene
C9I27_RS09600	cinA	1869760..1871031 (-)	1272	WP_002991356.1	competence/damage-inducible protein A	Machinery gene
C9I27_RS09605	-	1871100..1871660 (-)	561	WP_002991358.1	DNA-3-methyladenine glycosylase I	-
C9I27_RS09610	ruvA	1871670..1872266 (-)	597	WP_002991359.1	Holliday junction branch migration protein RuvA	Machinery gene
C9I27_RS09615	-	1872268..1873488 (-)	1221	WP_002991361.1	MFS transporter	-
C9I27_RS09620	hexB	1873499..1875481 (-)	1983	WP_002991363.1	DNA mismatch repair endonuclease MutL	Machinery gene
C9I27_RS09625	hexA	1875610..1878165 (-)	2556	WP_002991365.1	DNA mismatch repair protein MutS	Machinery gene
C9I27_RS10360	-	1878152..1878508 (-)	357	Protein_1794	YlbF family regulator	-
C9I27_RS09635	argR	1878505..1878942 (-)	438	WP_002982171.1	arginine repressor	-

Sequence

Protein

• Length: 660 a.a.
• Molecular weight: 74356.90 Da
• Isoelectric Point: 5.7597

>NTDB_id=238563 C9I27_RS09620 WP_002991363.1 1873499..1875481(-) (hexB) [Streptococcus pyogenes strain TJ11-001]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLVISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLNRLENEEQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGDVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide

• Length: 1983 bp

>NTDB_id=238563 C9I27_RS09620 WP_002991363.1 1873499..1875481(-) (hexB) [Streptococcus pyogenes strain TJ11-001]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAT
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTAAATACTACCAAAAAAATGCTGGTTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAATTAATGGCTTTAATTAGCACG
GCTATTTCAGAGAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGGCTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTCCGGCGCTGTTGACAACAGTGTAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGTTGAATCGCTTGGAAAATGAAGAGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCACGGAACTTATCTCTTTGCTCAGGGAAAAGATGGTTTATTT
ATAATTGACCAACACGCTGCCCAGGAGCGGGTTAAATACGAATATTATCGTGATAAGATTGGCGACGTTGACAGTAGTTT
ACAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTCGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTGCTTCTAACCAATGAGGTATCTATCAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

• MutL C terminal dimerisation domain (MutL_C) (462-604)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3) (25-118)

• DNA mismatch repair protein, C-terminal domain (DNA_mis_repair) (209-326)

3D structure

• AlphaFold DB: Q1JJH1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexB	Streptococcus pneumoniae R6	67.018	100	0.674