Detailed information NTG0238109

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CFN13_RS09545
• Genome accession: NZ_CP022291
• Coordinates: 1900053..1901096 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain EDCC5464
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1895053..1906096

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CFN13_RS09515 (CFN13_09505)	-	1895474..1896730 (-)	1257	WP_075583716.1	aminopeptidase	-
CFN13_RS09520 (CFN13_09510)	-	1896733..1896933 (-)	201	WP_000180460.1	DUF1128 family protein	-
CFN13_RS09525 (CFN13_09515)	-	1897080..1897544 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CFN13_RS09530 (CFN13_09520)	-	1897551..1897826 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CFN13_RS09535 (CFN13_09525)	-	1898104..1899321 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
CFN13_RS09540 (CFN13_09530)	vraR	1899434..1900063 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CFN13_RS09545 (CFN13_09535)	vraS	1900053..1901096 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CFN13_RS09550 (CFN13_09540)	liaF	1901093..1901794 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CFN13_RS09555 (CFN13_09545)	-	1901809..1902195 (-)	387	WP_001110179.1	hypothetical protein	-
CFN13_RS09560 (CFN13_09550)	map	1902412..1903170 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CFN13_RS09565 (CFN13_09555)	-	1903699..1904685 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
CFN13_RS09570 (CFN13_09560)	-	1905116..1905529 (-)	414	Protein_1773	hypothetical protein	-
CFN13_RS09575 (CFN13_09565)	-	1905558..1905668 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=238109 CFN13_RS09545 WP_001017131.1 1900053..1901096(-) (vraS) [Staphylococcus aureus strain EDCC5464]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=238109 CFN13_RS09545 WP_001017131.1 1900053..1901096(-) (vraS) [Staphylococcus aureus strain EDCC5464]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1