Detailed information NTG0234735

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CD795_RS10035
• Genome accession: NZ_CP021907
• Coordinates: 1973012..1974055 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Seattle 1945 isolate G478
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1968012..1979055

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CD795_RS10005	-	1968433..1969689 (-)	1257	WP_001793983.1	aminopeptidase	-
CD795_RS10010	-	1969692..1969892 (-)	201	WP_000180460.1	DUF1128 family protein	-
CD795_RS10015	-	1970039..1970503 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
CD795_RS10020	-	1970510..1970785 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CD795_RS10025	-	1971063..1972280 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
CD795_RS10030	vraR	1972393..1973022 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CD795_RS10035	vraS	1973012..1974055 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CD795_RS10040	liaF	1974052..1974753 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CD795_RS10045	-	1974768..1975154 (-)	387	WP_001110178.1	hypothetical protein	-
CD795_RS10050	map	1975371..1976129 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CD795_RS10055	-	1976885..1977871 (+)	987	WP_001014423.1	FUSC family protein	-
CD795_RS10060	-	1978060..1978473 (-)	414	WP_001643743.1	hypothetical protein	-
CD795_RS10065	-	1978502..1978612 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=234735 CD795_RS10035 WP_001017131.1 1973012..1974055(-) (vraS) [Staphylococcus aureus strain Seattle 1945 isolate G478]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=234735 CD795_RS10035 WP_001017131.1 1973012..1974055(-) (vraS) [Staphylococcus aureus strain Seattle 1945 isolate G478]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1