Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   M6_RS06440 Genome accession   NC_006086
Coordinates   1273717..1274754 (-) Length   345 a.a.
NCBI ID   WP_010922499.1    Uniprot ID   A0A4U9I5V9
Organism   Streptococcus pyogenes MGAS10394     
Function   processing of CSP (predicted from homology)   
Competence regulation

Genomic Context

Location: 1268717..1279754
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M6_RS06420 (M6_Spy1281) - 1269466..1270092 (+) 627 WP_011184760.1 prepilin peptidase -
  M6_RS06425 (M6_Spy1282) rlmN 1270174..1271253 (-) 1080 WP_011184761.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  M6_RS06430 (M6_Spy1283) - 1271257..1271877 (-) 621 WP_002992791.1 YutD family protein -
  M6_RS06435 (M6_Spy1285) - 1272325..1273301 (-) 977 Protein_1253 LacI family DNA-binding transcriptional regulator -
  M6_RS06440 (M6_Spy1287) sepM 1273717..1274754 (-) 1038 WP_010922499.1 SepM family pheromone-processing serine protease Regulator
  M6_RS06445 (M6_Spy1288) coaD 1274741..1275232 (-) 492 WP_002983821.1 pantetheine-phosphate adenylyltransferase -
  M6_RS06450 (M6_Spy1289) rsmD 1275222..1275761 (-) 540 WP_002983819.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  M6_RS06455 (M6_Spy1290) asnA 1275884..1276876 (-) 993 WP_011184764.1 aspartate--ammonia ligase -
  M6_RS06460 (M6_Spy1291) arcC 1277189..1278139 (-) 951 WP_011018011.1 carbamate kinase -
  M6_RS06465 (M6_Spy1292) - 1278159..1279490 (-) 1332 WP_011184765.1 dipeptidase -

Sequence

Protein


Download         Length: 345 a.a.        Molecular weight: 37541.24 Da        Isoelectric Point: 9.6692

>NTDB_id=23460 M6_RS06440 WP_010922499.1 1273717..1274754(-) (sepM) [Streptococcus pyogenes MGAS10394]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide


Download         Length: 1038 bp        

>NTDB_id=23460 M6_RS06440 WP_010922499.1 1273717..1274754(-) (sepM) [Streptococcus pyogenes MGAS10394]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(233-309)

PDZ domain (PDZ_2)

(129-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9I5V9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

69.275

100

0.693

Multiple sequence alignment