Detailed information NTG0232117

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: CCX85_RS06290
• Genome accession: NZ_CP021640
• Coordinates: 1242228..1243265 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain JS12
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1237228..1248265

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CCX85_RS06265 (CCX85_06275)	-	1237232..1237759 (-)	528	WP_002983837.1	Dps family protein	-
CCX85_RS06270 (CCX85_06280)	-	1237987..1238613 (+)	627	WP_038434165.1	prepilin peptidase	-
CCX85_RS06275 (CCX85_06285)	rlmN	1238695..1239774 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
CCX85_RS06280 (CCX85_06290)	-	1239778..1240398 (-)	621	WP_038434166.1	YutD family protein	-
CCX85_RS06285 (CCX85_06295)	-	1240846..1241823 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
CCX85_RS06290 (CCX85_06300)	sepM	1242228..1243265 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
CCX85_RS06295 (CCX85_06305)	coaD	1243252..1243743 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
CCX85_RS06300 (CCX85_06310)	rsmD	1243733..1244272 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
CCX85_RS06305 (CCX85_06315)	asnA	1244395..1245387 (-)	993	WP_002994813.1	aspartate--ammonia ligase	-
CCX85_RS06310 (CCX85_06320)	arcC	1245700..1246650 (-)	951	WP_002994815.1	carbamate kinase	-
CCX85_RS06315 (CCX85_06325)	-	1246670..1248001 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=232117 CCX85_RS06290 WP_010922499.1 1242228..1243265(-) (sepM) [Streptococcus pyogenes strain JS12]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=232117 CCX85_RS06290 WP_010922499.1 1242228..1243265(-) (sepM) [Streptococcus pyogenes strain JS12]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693