Detailed information NTG0023006

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: SMU_RS09560
• Genome accession: NC_004350
• Coordinates: 1962926..1965475 (-)
• Length: 849 a.a.
• NCBI ID: WP_002279585.1
• Uniprot ID: Q8DRW8
• Organism: Streptococcus mutans UA159
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1957926..1970475

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMU_RS09540 (SMU.2087)	-	1959055..1959615 (-)	561	WP_002262394.1	DNA-3-methyladenine glycosylase I	-
SMU_RS09545 (SMU.2088)	ruvA	1959697..1960290 (-)	594	WP_002262395.1	Holliday junction branch migration protein RuvA	Machinery gene
SMU_RS09550 (SMU.2089)	hexB	1960473..1962428 (-)	1956	WP_002262396.1	DNA mismatch repair endonuclease MutL	Machinery gene
SMU_RS09555	-	1962653..1962931 (+)	279	Protein_1857	transposase	-
SMU_RS09560 (SMU.2091c)	hexA	1962926..1965475 (-)	2550	WP_002279585.1	DNA mismatch repair protein MutS	Machinery gene
SMU_RS09565 (SMU.2092c)	-	1965468..1965815 (-)	348	WP_002264540.1	YlbF family regulator	-
SMU_RS09570 (SMU.2093)	argR	1965812..1966249 (-)	438	WP_002262400.1	arginine repressor	-
SMU_RS09575 (SMU.2094c)	-	1966672..1967169 (-)	498	WP_002262401.1	Crp/Fnr family transcriptional regulator	-
SMU_RS10225 (SMU.2096c)	-	1967644..1967868 (-)	225	WP_002262403.1	hypothetical protein	-
SMU_RS09585	-	1968106..1968546 (+)	441	Protein_1863	arginine repressor	-
SMU_RS09590 (SMU.2098)	argS	1968647..1970338 (+)	1692	WP_002262405.1	arginine--tRNA ligase	-

Sequence

Protein

• Length: 849 a.a.
• Molecular weight: 95340.65 Da
• Isoelectric Point: 4.9844

>NTDB_id=23006 SMU_RS09560 WP_002279585.1 1962926..1965475(-) (hexA) [Streptococcus mutans UA159]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAIKAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLI
DLGYKVAIAEQMEDPKKAVGVVKREVVQVITPGTVVDSTKPDSANNFLVSLDTDGSQFGLSYMDLSTGEFYATTLADLPA
VRSEVLNLKTRELVIGFELSENEDQLFRKQMNLLLSFEKTVYDDVHLLDDQLKAIELAAAGKLLQYVHNTQKRELSHLQK
LVHYEIKDYLQMAYATKSSLDLLENARSGKKHGSLYWLLDETKTAMGTRLLRTWIDRPLVSSSLISKRQDIIQTFLDHFF
ERSDLSDSLKGVYDIERLASRVSFGKANPKDLLQLGQTLSQVPVIKTILESFASSSLESLINQIDTLPELEALIRSAIDS
NAPITITEGGMIREGFDETLDKYRTVMREGTSWIADIETKERQKSGISTLKIDYNKKDGYYFHVTNSNLSLVPDYFFRKA
TLKNSERFGTAELAKIEGEMLEAREESANLEYDIFMRIRSQVESYIERLQNLAKSLATVDVLQSLAVVAENNHYVRPSFN
HQQEISIENGRHAVVEKVMGSQEYIPNTINFDQKTSIQLITGPNMSGKSTYMRQLALTVIMAQLGSFVAADSADLPIFDA
IFTRIGAADDLISGQSTFMVEMMEANHAIKAATPNSLILFDELGRGTATYDGMALAQAIIEYIHNKVGAKTLFATHYHEL
TDLSTRLTSLVNVHVATLEKDGEVTFLHKIADGPADKSYGIHVAKIAGLPKDLLNRADHILVDLEKMSAAVSVNLKNETK
ESQPVEEQLSLFAIDNNYEELIKKLKQLDLTNLTPRESMNALFDLKELL

Nucleotide

• Length: 2550 bp

>NTDB_id=23006 SMU_RS09560 WP_002279585.1 1962926..1965475(-) (hexA) [Streptococcus mutans UA159]
ATGACTAAGGAAAAACTCTCTCCAGGAATGCAGCAGTATTTGGATATCAAAAAAGACTATCCAGATGCTTTTTTGCTTTT
CCGCATGGGAGACTTTTATGAACTATTTTATGATGATGCTATCAAGGCCGCTCAAATTTTAGAAATTAGCTTAACAAGTC
GTAATAAAAATGCTGACAATCCTATTCCGATGGCTGGTGTCCCTTATCATTCAGCTCAACAGTATATTGATGTTTTGATT
GATTTGGGTTATAAGGTTGCCATTGCTGAGCAGATGGAAGACCCTAAAAAAGCTGTTGGCGTTGTCAAACGTGAAGTGGT
TCAAGTGATTACCCCGGGTACTGTTGTTGATTCAACTAAGCCAGACAGTGCTAATAATTTTTTAGTCTCTCTGGATACTG
ATGGCAGTCAGTTTGGCCTTTCTTACATGGATTTATCTACTGGGGAATTTTATGCGACAACATTAGCAGATTTGCCAGCA
GTGAGAAGCGAAGTCCTCAATCTCAAGACGCGTGAATTAGTTATTGGTTTTGAACTGAGTGAGAATGAAGATCAGCTTTT
TCGTAAGCAGATGAACCTGCTCTTATCTTTTGAAAAAACTGTCTATGACGATGTACATTTATTGGATGATCAATTAAAAG
CAATAGAACTTGCTGCAGCTGGCAAACTCTTGCAATATGTTCATAACACACAAAAACGTGAGTTGAGTCATTTGCAAAAG
TTGGTGCATTATGAAATCAAAGATTACTTGCAGATGGCTTATGCTACAAAATCTAGCTTGGATCTGTTAGAAAATGCCAG
AAGCGGGAAAAAACACGGCAGTCTCTACTGGCTTTTAGATGAGACAAAAACAGCTATGGGGACACGTCTTTTGCGAACTT
GGATTGATCGTCCTTTGGTCAGTTCAAGCCTTATCAGTAAACGTCAAGATATTATTCAGACTTTTCTAGATCACTTTTTT
GAGCGCAGTGATCTTAGTGACAGCCTAAAAGGTGTTTATGATATTGAACGTTTGGCCAGCCGTGTTTCATTTGGGAAGGC
CAATCCTAAGGATTTATTGCAATTGGGTCAGACCTTAAGTCAAGTTCCTGTCATTAAGACTATTCTTGAAAGTTTTGCCA
GTTCTAGTTTGGAAAGCCTAATTAATCAAATTGATACTCTTCCAGAATTGGAAGCATTGATTCGTTCGGCTATTGACTCT
AATGCACCTATAACTATTACAGAAGGCGGTATGATTCGAGAGGGGTTTGATGAAACTTTAGATAAGTATCGAACGGTAAT
GCGCGAAGGGACGAGTTGGATTGCTGACATTGAGACTAAGGAACGTCAGAAAAGCGGCATCTCAACCTTGAAGATTGATT
ATAACAAAAAAGACGGTTATTATTTCCATGTCACCAACTCTAATTTGTCTTTAGTACCAGATTACTTCTTTAGAAAGGCA
ACGCTTAAAAATTCTGAGCGCTTTGGGACAGCAGAGCTTGCAAAAATTGAAGGTGAAATGTTAGAAGCGCGTGAAGAATC
AGCCAATTTAGAATATGATATTTTCATGCGTATCAGATCACAGGTTGAATCTTATATTGAGCGTCTTCAAAATCTGGCCA
AGAGTCTAGCAACTGTTGATGTTTTGCAAAGTTTAGCAGTAGTAGCTGAGAATAATCATTATGTCAGACCTTCTTTTAAT
CATCAGCAGGAAATCAGTATTGAAAATGGTCGCCATGCTGTTGTTGAGAAGGTTATGGGAAGCCAAGAATATATTCCCAA
TACTATCAATTTTGACCAAAAGACTAGTATTCAACTGATTACTGGACCTAATATGAGCGGTAAGTCAACTTACATGCGGC
AATTAGCTCTGACAGTTATTATGGCTCAATTAGGTTCTTTTGTAGCAGCTGATTCAGCTGATTTGCCGATTTTTGATGCT
ATTTTTACACGTATTGGTGCTGCAGATGATTTAATTTCAGGGCAGTCTACCTTTATGGTAGAGATGATGGAAGCCAATCA
TGCTATCAAGGCAGCGACACCTAATTCACTCATTTTATTTGATGAATTAGGACGTGGTACAGCAACTTATGATGGTATGG
CTTTAGCACAGGCTATTATTGAGTATATTCATAATAAAGTTGGAGCTAAAACGCTATTTGCTACCCATTATCATGAGTTG
ACAGACTTGTCAACTAGATTGACAAGTCTTGTCAATGTACATGTTGCTACTCTTGAAAAAGATGGAGAGGTCACTTTTCT
TCATAAAATTGCTGATGGACCAGCTGATAAATCTTATGGAATCCATGTTGCTAAAATTGCCGGCTTGCCTAAAGATTTAC
TTAATCGAGCTGATCACATATTAGTTGATTTAGAAAAAATGAGTGCAGCTGTCTCAGTCAATCTAAAAAACGAGACCAAA
GAAAGCCAACCTGTGGAAGAGCAGTTGTCACTTTTTGCTATTGATAATAATTATGAAGAATTAATCAAAAAATTGAAACA
GTTGGACCTTACCAATTTAACACCAAGAGAATCCATGAATGCCTTATTTGATTTGAAGGAACTATTATAA

Domains

Predicted by InterProScan.

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain V (MutS_V) (599-785)

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (256-546)

3D structure

• AlphaFold DB: Q8DRW8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	72.033	100	0.722
mutS	Pseudomonas stutzeri strain ATCC 17587	37.326	100	0.378