Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HH_RS00100 Genome accession   NC_004917
Coordinates   18792..20657 (+) Length   621 a.a.
NCBI ID   WP_011114862.1    Uniprot ID   Q7VK73
Organism   Helicobacter hepaticus ATCC 51449     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 13792..25657
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HH_RS00075 (HH0015) - 13936..15108 (+) 1173 WP_011114858.1 glutathionylspermidine synthase family protein -
  HH_RS09070 (HH0016) - 15102..16670 (-) 1569 WP_011114859.1 BspA family leucine-rich repeat surface protein -
  HH_RS00085 (HH0017) - 16692..18134 (-) 1443 WP_011114860.1 L-aspartate oxidase -
  HH_RS00090 - 18134..18352 (-) 219 WP_041309167.1 hypothetical protein -
  HH_RS00095 (HH0018) - 18344..18802 (+) 459 WP_011114861.1 hypothetical protein -
  HH_RS00100 (HH0019) uvrC 18792..20657 (+) 1866 WP_011114862.1 excinuclease ABC subunit UvrC Machinery gene
  HH_RS00105 (HH0020) - 20679..22151 (+) 1473 WP_041308887.1 hypothetical protein -
  HH_RS00110 (HH0021) - 22148..23623 (+) 1476 WP_011114864.1 sensor histidine kinase -
  HH_RS00115 (HH0022) - 23613..24287 (+) 675 WP_011114865.1 response regulator -

Sequence

Protein


Download         Length: 621 a.a.        Molecular weight: 71812.84 Da        Isoelectric Point: 9.9025

>NTDB_id=22994 HH_RS00100 WP_011114862.1 18792..20657(+) (uvrC) [Helicobacter hepaticus ATCC 51449]
MSNKESTSYNLLVHLADLPTQSGIYQFFDNEDTLLYVGKAKNLKNRIKSYLSIENKHIVPKNNLSPRIALMVSQITRIHT
LLTNNEQDALILENSLIKSLKPKYNILLRDDKTYPYIYIDKSLPYPRFELTRQVLKSNQIQYFGPFVSGARELLDSLYDN
LPLVQKKSCVKGKKACIFHQIHKCPAPCENKVSIQTYAQTIAQGIALIEDKKALLKILESKMHTLSHNLQFEEAAIMRDR
IQKITQMKNQSIIDMMSGDYDVFVLQEQDCGKNSQDSHKKSHTALHTHILMMLFIRNGRIISSDFILLHDDIQSHNLPQL
YTQALLNHYKTQIPLLPQEILIPPFDFPDLLHLQQLLREQTRSSLKIVQPQRGAKKDLLQLAHKNALEIRRLHTQQNNTF
STLVSIKELCVLSQIPYSIEVFDTSHHSGTHNVGGMIVYENDDFIRSKYRRYELHTSDEYSQMHEMLLRRAQSFDSNPPP
ALWLLDGGRAQINLALDILKSVGANVEVLAIAKMKHNAKAYRAKGNAFDILRSKNAEFKLKPNDKRLQFLQKLRDEVHRY
AITYHRYKKQKDIQKAQMMGKNYTQAQIKKLLDYFGSFESLKTASQEQINSVLSRRNRSDT

Nucleotide


Download         Length: 1866 bp        

>NTDB_id=22994 HH_RS00100 WP_011114862.1 18792..20657(+) (uvrC) [Helicobacter hepaticus ATCC 51449]
ATGAGCAATAAAGAATCTACAAGTTATAATCTCCTTGTGCATTTAGCAGATTTACCAACACAATCTGGCATTTATCAATT
TTTTGATAATGAAGATACTTTACTCTATGTAGGCAAAGCAAAGAATCTAAAAAACCGCATTAAAAGCTACTTGAGTATTG
AAAACAAACATATTGTGCCAAAAAATAATCTTAGTCCAAGAATCGCTCTTATGGTATCTCAAATCACTCGTATCCATACA
CTTTTAACAAATAATGAACAAGATGCGCTTATCCTTGAAAATTCTCTTATCAAAAGCCTCAAACCAAAATATAATATCCT
TTTGCGCGATGATAAAACTTATCCTTATATTTACATTGATAAATCCCTTCCCTATCCTCGCTTTGAGCTCACTCGCCAAG
TGCTCAAATCAAATCAGATTCAATATTTTGGACCTTTTGTAAGCGGAGCAAGGGAATTACTTGATAGCCTCTATGATAAT
CTACCACTTGTGCAGAAAAAATCCTGTGTCAAAGGCAAAAAAGCGTGTATTTTTCATCAGATTCACAAATGTCCTGCACC
TTGTGAGAATAAAGTTTCCATACAGACTTATGCCCAAACTATTGCACAAGGTATTGCACTTATTGAAGACAAAAAAGCCT
TATTAAAAATACTAGAATCTAAAATGCATACCCTCTCTCATAATCTGCAATTTGAAGAAGCTGCTATAATGCGTGATAGA
ATCCAAAAAATTACACAAATGAAAAACCAATCTATTATTGATATGATGAGCGGAGATTATGATGTATTTGTATTACAAGA
ACAAGATTGTGGCAAAAACTCGCAAGATTCTCACAAAAAATCTCATACTGCGTTGCATACGCATATTTTAATGATGCTTT
TTATCCGCAATGGACGCATTATTTCAAGTGATTTTATCCTTTTACACGATGATATACAATCCCATAATCTTCCACAACTC
TACACCCAAGCTTTACTTAACCATTATAAAACTCAAATACCACTCTTACCTCAAGAGATTCTCATTCCTCCATTTGACTT
TCCTGACTTACTGCATTTACAACAACTCTTAAGAGAGCAAACGCGCAGTTCTCTCAAAATCGTCCAACCACAAAGAGGTG
CAAAAAAAGACTTGCTACAACTCGCACATAAAAATGCTCTTGAAATAAGACGATTACATACACAGCAAAACAATACATTC
TCTACACTTGTAAGCATTAAAGAGTTGTGTGTATTAAGCCAAATACCTTATTCTATTGAGGTTTTTGATACCTCTCATCA
TAGCGGAACACACAATGTGGGCGGTATGATTGTGTATGAAAATGATGATTTTATTCGTTCTAAATATCGGCGATATGAGC
TTCACACAAGTGATGAATACAGCCAAATGCACGAAATGCTTTTACGCCGAGCTCAAAGTTTTGATTCTAATCCACCACCT
GCCTTATGGCTACTTGATGGAGGCAGGGCACAAATTAATCTAGCTCTTGATATTTTAAAAAGCGTAGGGGCAAATGTTGA
AGTCCTAGCAATTGCTAAAATGAAACATAATGCCAAAGCTTATCGTGCAAAAGGTAATGCTTTTGATATTTTGCGAAGCA
AAAATGCAGAGTTTAAACTAAAACCAAACGATAAAAGACTACAATTCCTCCAAAAACTCCGTGATGAAGTGCATCGTTAT
GCTATCACTTATCACCGCTATAAAAAACAAAAAGATATACAAAAGGCACAAATGATGGGAAAAAATTATACTCAAGCACA
AATTAAAAAACTTTTAGATTACTTTGGTAGCTTTGAATCTCTTAAAACTGCTTCACAAGAGCAAATTAATAGCGTGCTTT
CGCGCAGAAATCGTTCAGATACTTAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(214-244)

GIY-YIG catalytic domain (GIY-YIG)

(22-105)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(408-562)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q7VK73

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

49.425

98.068

0.485

Multiple sequence alignment