Detailed information NTG0228225

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: B4893_RS09625
• Genome accession: NZ_CP021105
• Coordinates: 1895818..1896861 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CC5
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1890818..1901861

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B4893_RS09595 (B4893_09490)	-	1891239..1892495 (-)	1257	WP_001795108.1	aminopeptidase	-
B4893_RS09600 (B4893_09495)	-	1892498..1892698 (-)	201	WP_000180460.1	DUF1128 family protein	-
B4893_RS09605 (B4893_09500)	-	1892845..1893309 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
B4893_RS09610 (B4893_09505)	-	1893316..1893591 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
B4893_RS09615 (B4893_09510)	-	1893869..1895086 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
B4893_RS09620 (B4893_09515)	vraR	1895199..1895828 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
B4893_RS09625 (B4893_09520)	vraS	1895818..1896861 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
B4893_RS09630 (B4893_09525)	liaF	1896858..1897559 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
B4893_RS09635 (B4893_09530)	-	1897574..1897960 (-)	387	WP_001110179.1	hypothetical protein	-
B4893_RS09640 (B4893_09535)	map	1898177..1898935 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
B4893_RS09650 (B4893_09545)	-	1899466..1900452 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
B4893_RS09660 (B4893_09550)	-	1900883..1901296 (-)	414	WP_001557448.1	hypothetical protein	-
B4893_RS09665 (B4893_09555)	-	1901325..1901435 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=228225 B4893_RS09625 WP_001017131.1 1895818..1896861(-) (vraS) [Staphylococcus aureus strain CC5]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=228225 B4893_RS09625 WP_001017131.1 1895818..1896861(-) (vraS) [Staphylococcus aureus strain CC5]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1