Detailed information NTG0227473

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: B9T45_RS10155
• Genome accession: NZ_CP020959
• Coordinates: 1957783..1958826 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain H489
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1952783..1963826

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B9T45_RS10125 (B9T45_10125)	-	1953201..1954457 (-)	1257	WP_001795438.1	aminopeptidase	-
B9T45_RS10130 (B9T45_10130)	-	1954460..1954660 (-)	201	WP_000180461.1	DUF1128 family protein	-
B9T45_RS10135 (B9T45_10135)	-	1954807..1955271 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
B9T45_RS10140 (B9T45_10140)	-	1955278..1955553 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
B9T45_RS10145 (B9T45_10145)	-	1955831..1957048 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
B9T45_RS10150 (B9T45_10150)	vraR	1957164..1957793 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
B9T45_RS10155 (B9T45_10155)	vraS	1957783..1958826 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
B9T45_RS10160 (B9T45_10160)	liaF	1958823..1959524 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
B9T45_RS10165 (B9T45_10165)	-	1959539..1959925 (-)	387	WP_001110179.1	hypothetical protein	-
B9T45_RS10170 (B9T45_10170)	map	1960142..1960900 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
B9T45_RS10180 (B9T45_10180)	-	1961372..1962358 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
B9T45_RS10195 (B9T45_10195)	-	1962907..1963320 (-)	414	WP_001549145.1	hypothetical protein	-
B9T45_RS10200 (B9T45_10200)	-	1963349..1963459 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=227473 B9T45_RS10155 WP_001017131.1 1957783..1958826(-) (vraS) [Staphylococcus aureus strain H489]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=227473 B9T45_RS10155 WP_001017131.1 1957783..1958826(-) (vraS) [Staphylococcus aureus strain H489]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1