Detailed information NTG0022571

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: SPYM18_RS04085
• Genome accession: NC_003485
• Coordinates: 775737..777836 (-)
• Length: 699 a.a.
• NCBI ID: WP_011017682.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes MGAS8232
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 770737..782836

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYM18_RS04055 (spyM18_0943)	-	771214..772053 (+)	840	WP_011017679.1	thymidylate synthase	-
SPYM18_RS04060 (spyM18_0944)	-	772133..772630 (+)	498	WP_011017680.1	dihydrofolate reductase	-
SPYM18_RS10315 (spyM18_0945)	-	772650..772820 (+)	171	WP_002990165.1	hypothetical protein	-
SPYM18_RS04070 (spyM18_0946)	clpX	772950..774179 (+)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
SPYM18_RS04075 (spyM18_0947)	yihA	774189..774788 (+)	600	WP_011017681.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
SPYM18_RS04080 (spyM18_0948)	-	774936..775679 (+)	744	WP_002984942.1	hypothetical protein	-
SPYM18_RS04085 (spyM18_0949)	clpC	775737..777836 (-)	2100	WP_011017682.1	AAA family ATPase	Regulator
SPYM18_RS04090 (spyM18_0950)	rpiA	778214..778897 (+)	684	WP_011017683.1	ribose-5-phosphate isomerase RpiA	-
SPYM18_RS04095 (spyM18_0951)	-	778974..780185 (+)	1212	WP_011017684.1	phosphopentomutase	-
SPYM18_RS04100 (spyM18_0952)	arsC	780204..780644 (+)	441	WP_002984932.1	arsenate reductase (glutaredoxin)	-
SPYM18_RS04105 (spyM18_0953)	-	780628..781437 (+)	810	WP_002984930.1	purine-nucleoside phosphorylase	-
SPYM18_RS04110 (spyM18_0955)	deoD	782100..782813 (+)	714	WP_002990147.1	purine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 699 a.a.
• Molecular weight: 77311.30 Da
• Isoelectric Point: 5.5456

>NTDB_id=22571 SPYM18_RS04085 WP_011017682.1 775737..777836(-) (clpC) [Streptococcus pyogenes MGAS8232]
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEAHQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Nucleotide

• Length: 2100 bp

>NTDB_id=22571 SPYM18_RS04085 WP_011017682.1 775737..777836(-) (clpC) [Streptococcus pyogenes MGAS8232]
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAACCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCATCAAGGGCATCTTGACCCCGTCATTGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCCGCTATTAAAAACAAGGAAATCGTATCAATTGACATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTTGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGTCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAAGCC
AAAATGTTACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCTGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTCGCAGCAGT
AGCACGTGCTATTCGACGAAATCGAGCAGGTTTTGATGATGGTAACCGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGAGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TCATTACACTTCTTCTACAAGTGTTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGAGTCTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAATTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTGCTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCACGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAGGCAAAACGATCAGTAA

Domains

Predicted by InterProScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (118-250)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (607-678)

• AAA domain (Cdc48 subfamily) (AAA_2) (443-600)

• AAA lid domain (AAA_lid_9) (259-353)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	46.942	100	0.472
clpE	Streptococcus mutans UA159	49.068	92.132	0.452
clpE	Streptococcus pneumoniae TIGR4	49.278	89.127	0.439
clpE	Streptococcus pneumoniae Rx1	49.278	89.127	0.439
clpE	Streptococcus pneumoniae D39	49.278	89.127	0.439
clpE	Streptococcus pneumoniae R6	49.278	89.127	0.439
clpC	Bacillus subtilis subsp. subtilis str. 168	44.662	95.136	0.425
clpC	Streptococcus thermophilus LMD-9	42.79	91.273	0.391
clpC	Streptococcus pneumoniae Rx1	41.718	93.276	0.389
clpC	Streptococcus pneumoniae D39	41.718	93.276	0.389
clpC	Streptococcus thermophilus LMG 18311	42.587	90.701	0.386
clpC	Streptococcus pneumoniae TIGR4	42.698	90.129	0.385
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.194	93.419	0.385
clpC	Streptococcus mutans UA159	41.562	91.559	0.381