Detailed information NTG0225299

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: B7R57_RS12100
• Genome accession: NZ_CP020656
• Coordinates: 2337306..2338349 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain K5
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2332306..2343349

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B7R57_RS12070 (B7R57_12095)	-	2332793..2332903 (+)	111	WP_001790257.1	hypothetical protein	-
B7R57_RS12075 (B7R57_12100)	-	2332932..2333345 (+)	414	WP_001670387.1	hypothetical protein	-
B7R57_RS12080 (B7R57_12110)	-	2333717..2334703 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
B7R57_RS12085 (B7R57_12120)	map	2335232..2335990 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
B7R57_RS12090 (B7R57_12125)	-	2336207..2336593 (+)	387	WP_001110179.1	hypothetical protein	-
B7R57_RS12095 (B7R57_12130)	liaF	2336608..2337309 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
B7R57_RS12100 (B7R57_12135)	vraS	2337306..2338349 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
B7R57_RS12105 (B7R57_12140)	vraR	2338339..2338968 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
B7R57_RS12110 (B7R57_12145)	-	2339080..2340297 (-)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
B7R57_RS12115 (B7R57_12150)	-	2340575..2340850 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
B7R57_RS12120 (B7R57_12155)	-	2340857..2341321 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
B7R57_RS12125 (B7R57_12160)	-	2341468..2341668 (+)	201	WP_000180460.1	DUF1128 family protein	-
B7R57_RS12130 (B7R57_12165)	-	2341671..2342927 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=225299 B7R57_RS12100 WP_001017131.1 2337306..2338349(+) (vraS) [Staphylococcus aureus strain K5]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=225299 B7R57_RS12100 WP_001017131.1 2337306..2338349(+) (vraS) [Staphylococcus aureus strain K5]
ATGAACCACTATATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1