Detailed information NTG0225087

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: B7H15_RS10500
• Genome accession: NZ_CP020619
• Coordinates: 2027842..2028885 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JE2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2022842..2033885

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B7H15_RS10470 (B7H15_10470)	-	2023260..2024516 (-)	1257	WP_001795438.1	aminopeptidase	-
B7H15_RS10475 (B7H15_10475)	-	2024519..2024719 (-)	201	WP_000180461.1	DUF1128 family protein	-
B7H15_RS10480 (B7H15_10480)	-	2024866..2025330 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
B7H15_RS10485 (B7H15_10485)	-	2025337..2025612 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
B7H15_RS10490 (B7H15_10490)	-	2025890..2027107 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
B7H15_RS10495 (B7H15_10495)	vraR	2027223..2027852 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
B7H15_RS10500 (B7H15_10500)	vraS	2027842..2028885 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
B7H15_RS10505 (B7H15_10505)	liaF	2028882..2029583 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
B7H15_RS10510 (B7H15_10510)	-	2029598..2029984 (-)	387	WP_001110179.1	hypothetical protein	-
B7H15_RS10515 (B7H15_10515)	map	2030201..2030959 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
B7H15_RS10520 (B7H15_10520)	-	2031487..2032473 (+)	987	WP_000999713.1	FUSC family protein	-
B7H15_RS10530 (B7H15_10530)	-	2032963..2033376 (-)	414	WP_001549145.1	hypothetical protein	-
B7H15_RS10535 (B7H15_10535)	-	2033405..2033515 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=225087 B7H15_RS10500 WP_001017131.1 2027842..2028885(-) (vraS) [Staphylococcus aureus strain JE2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=225087 B7H15_RS10500 WP_001017131.1 2027842..2028885(-) (vraS) [Staphylococcus aureus strain JE2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1