Detailed information NTG0224904

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: BSR25_RS05470
• Genome accession: NZ_CP020604
• Coordinates: 1102368..1103843 (-)
• Length: 491 a.a.
• NCBI ID: WP_010906048.1
• Uniprot ID: A0A2A9ICZ0
• Organism: Lactococcus lactis subsp. lactis bv. diacetylactis strain FM03
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1097368..1108843

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BSR25_RS05455 (BSR25_1081)	murD	1098628..1099980 (-)	1353	WP_003130748.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
BSR25_RS05460 (BSR25_1083)	-	1100471..1100812 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
BSR25_RS05465 (BSR25_1084)	-	1100944..1102185 (-)	1242	WP_003130753.1	ammonium transporter	-
BSR25_RS05470 (BSR25_1085)	covS	1102368..1103843 (-)	1476	WP_010906048.1	HAMP domain-containing histidine kinase	Regulator
BSR25_RS05475 (BSR25_1086)	covR	1103851..1104543 (-)	693	WP_003130756.1	response regulator transcription factor	Regulator
BSR25_RS05480 (BSR25_1087)	-	1104699..1105229 (-)	531	WP_003130758.1	YceD family protein	-
BSR25_RS05485 (BSR25_1088)	-	1105360..1105605 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
BSR25_RS05490 (BSR25_1089)	-	1105761..1106225 (-)	465	WP_003130761.1	hypothetical protein	-
BSR25_RS05495 (BSR25_1090)	-	1106307..1106669 (-)	363	WP_010906050.1	TIGR02328 family protein	-
BSR25_RS05505 (BSR25_1091)	-	1107154..1107651 (-)	498	WP_226898137.1	CHAP domain-containing protein	-
BSR25_RS05510 (BSR25_1092)	-	1107745..1108581 (-)	837	WP_003130766.1	metallophosphoesterase	-

Sequence

Protein

• Length: 491 a.a.
• Molecular weight: 56195.08 Da
• Isoelectric Point: 4.8253

>NTDB_id=224904 BSR25_RS05470 WP_010906048.1 1102368..1103843(-) (covS) [Lactococcus lactis subsp. lactis bv. diacetylactis strain FM03]
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQLLTRSMDSVEEVLEKADAPL
NSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKII
SKSTGQVVGYLQAFYDTTTYHRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHDDFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
STFTLKFPKIK

Nucleotide

• Length: 1476 bp

>NTDB_id=224904 BSR25_RS05470 WP_010906048.1 1102368..1103843(-) (covS) [Lactococcus lactis subsp. lactis bv. diacetylactis strain FM03]
ATGAAAAAACTATTTACTTTCAATAAGAAAAAAGAGACGGTAGAGGAAAGTTCGGCTAAGCGGTCTATCATGCTTAGGTG
GGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTTTGTTTGCTACTTTGACTTATCAATTGACAATCAGTTCTT
TTATTAAAGAAGAACAACAATTATTAACTCGCTCTATGGATAGTGTTGAGGAAGTCTTAGAAAAAGCAGATGCTCCTTTG
AATTCATCGAATTTGAACACATATATTGAAGCGACATCAAAGATTCAAAATGGTGAGTCTGAAGGAATGAGTTTGGGTAG
TATCATTGGGACACGGAAAGCATTTTATATTTATGACTTAAATCATAAATTATTGTATTCAACGAATCGACATACTTTTG
GTTTTCAGAATCAGGCTAATAATGAAATGAAAGAGATTCGGGGAGAAAATCCAGGTTATTTAGTTCAGAGAAAAATTATT
TCTAAGTCAACAGGACAAGTTGTGGGATACTTACAGGCTTTTTATGATACGACGACTTATCATCGAATTTCTAATCTTCT
TTTGATTGTCTTGTTAATTTTAGAAATTGTTGCCTTGATTGTCGCTCAGTTGATTGGTTATTTCATGGCTAATTACTTTA
TGAAACCATTGGAAAAACTTTATCAGGGCATGCAAGAAATGGCAAATGATCCAACAAATGATTTTGAACCGATTGAAATT
CAAAGTGGAGATGAAATCGAAGAGTTGGCTCATGTTTACAATGATATGATGTTGAAGATGAAGGCATATCTTGAACAGCA
AAATCGCTTTGTTTCTGATGTTTCTCATGAATTAAGAACACCTTTAGCTGTCTTGGATGGACATATTAACTTGTTGAATC
GATGGGGGAAAAATGATCCAGAAGTATTAGATGAATCTTTGCAGGCAAGTTTAGATGAAGTTGATCGAATGAAGAAAATG
CTTGAGGAGATGTTGGCTCTTGCTCGCCTTGAAAATGTTGACTTATCAAGTGAAGAACTGGATTGTGATGTTGGAAAAGT
TTGTAATCGGGCCCTTAAGAATTTTCAGCTTTTGCATGATGATTTTGAAATAGTGCTTGATAACCGGCTTATTTATCCCA
CTCATGCGCGAATTTCAGAAAATCATTTTGAACAAGGGTTACGAATTCTGTTAGATAATGCTGCTAAATACTCTCCTGAT
GATCGTAAAGAAATCGTGATTACTGTTTCTGAGGATGAACAGTTTGTGATTACGAGTGTATCTGACAAAGGAATTGGAAT
TTCAGAAGAAGATATTAATCATCTTTTTGAGCGTTTCTTTAGAGCGGACAAGGCTCGCAATCGAGAAATTGGTGGAACTG
GTTTAGGTTTATCAATTTTAGCTCGATTGGCAGAAAATTATCAAGGGGAAATTGAGGTAAATTCAGAACTGGGTCTTGGT
TCAACTTTTACACTAAAATTCCCGAAAATAAAATAA

Domains

Predicted by InterproScan.

• ArlS sensor domain (ArlS_N) (54-185)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (380-489)

• HAMP domain (HAMP) (208-258)

• His Kinase A (phospho-acceptor) domain (HisKA) (267-332)

3D structure

• AlphaFold DB: A0A2A9ICZ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1