Detailed information NTG0022424

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: SMU_RS06910
• Genome accession: NC_004350
• Coordinates: 1450307..1451188 (-)
• Length: 293 a.a.
• NCBI ID: WP_002262935.1
• Uniprot ID: Q8DT59
• Organism: Streptococcus mutans UA159
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1445307..1456188

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMU_RS06885 (SMU.1517)	vicR	1446201..1446908 (-)	708	WP_002262930.1	response regulator YycF	Regulator
SMU_RS06890 (SMU.1519)	-	1447261..1448043 (+)	783	WP_002262931.1	amino acid ABC transporter ATP-binding protein	-
SMU_RS06895 (SMU.1520)	-	1448040..1448852 (+)	813	WP_002262932.1	transporter substrate-binding domain-containing protein	-
SMU_RS06900 (SMU.1521)	-	1448870..1449574 (+)	705	WP_002262933.1	amino acid ABC transporter permease	-
SMU_RS06905 (SMU.1522)	-	1449589..1450239 (+)	651	WP_002262934.1	amino acid ABC transporter permease	-
SMU_RS06910 (SMU.1523)	endA	1450307..1451188 (-)	882	WP_002262935.1	DNA/RNA non-specific endonuclease	Machinery gene
SMU_RS06915 (SMU.1524c)	-	1451230..1451418 (-)	189	WP_002262936.1	DNA-directed RNA polymerase subunit beta	-
SMU_RS06920 (SMU.1525)	murA	1451421..1452692 (-)	1272	WP_002262937.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SMU_RS06925 (SMU.1526c)	-	1452758..1452991 (-)	234	WP_002285829.1	DUF1146 family protein	-
SMU_RS06930 (SMU.1527)	-	1453264..1453680 (-)	417	WP_002262939.1	F0F1 ATP synthase subunit epsilon	-
SMU_RS06935 (SMU.1528)	atpD	1453694..1455100 (-)	1407	WP_002262940.1	F0F1 ATP synthase subunit beta	-
SMU_RS06940 (SMU.1529)	-	1455126..1456004 (-)	879	WP_002262941.1	F0F1 ATP synthase subunit gamma	-

Sequence

Protein

• Length: 293 a.a.
• Molecular weight: 32130.72 Da
• Isoelectric Point: 9.5337

>NTDB_id=22424 SMU_RS06910 WP_002262935.1 1450307..1451188(-) (endA) [Streptococcus mutans UA159]
MTRKTNKSQRKQQKLCLSLLAALSVFVCTYIATSDHIADSNPIKQAAQLLTGKNKDILSNGSMSHQATPSQELANTVMTD
AVKNALGRQIEWSGAGSFIINHNKTDLNADVASQPYASNQTKIVQGQTVPTVANALLSKATRQYRNRQETGNGRTNWQPA
GWHQLYDLPGDYDHAVDRGHLLAYALVGGLKRFDASTSNPQNVATQAAWANEANSSNSRGQNYYETLIRKALDSHKRVRY
RVTLIYDDNNDILASGSHLEAKSSDGSLEFNVFIPNVQSGLTFDYATGQVKAN

Nucleotide

• Length: 882 bp

>NTDB_id=22424 SMU_RS06910 WP_002262935.1 1450307..1451188(-) (endA) [Streptococcus mutans UA159]
ATGACTAGAAAAACGAACAAGTCTCAGCGAAAACAGCAAAAATTATGCTTATCTCTCCTTGCTGCTTTGAGCGTATTTGT
TTGTACTTATATTGCAACCAGTGATCATATTGCTGATAGTAACCCTATAAAGCAGGCTGCCCAATTATTGACAGGTAAAA
ACAAGGATATACTTTCAAATGGTTCAATGAGCCATCAAGCGACTCCCAGTCAAGAATTAGCCAATACTGTTATGACGGAT
GCAGTAAAAAATGCCTTGGGTAGACAAATTGAATGGAGTGGTGCAGGTTCTTTCATTATTAATCATAATAAAACTGACCT
TAACGCTGATGTTGCTAGCCAACCGTATGCTAGTAATCAGACCAAAATCGTTCAAGGACAGACAGTACCAACAGTAGCAA
ATGCTTTGTTAAGTAAGGCTACTCGTCAGTACCGAAACCGCCAAGAGACAGGAAATGGCAGGACAAATTGGCAGCCAGCA
GGCTGGCATCAGCTTTATGATTTGCCGGGTGACTATGATCACGCGGTTGATCGTGGACACTTATTGGCTTATGCTTTGGT
TGGTGGTTTGAAACGATTTGATGCTTCAACGAGTAATCCTCAAAATGTAGCAACACAAGCAGCTTGGGCTAATGAAGCCA
ATAGTTCAAACTCAAGGGGACAAAATTATTATGAAACACTGATTAGAAAAGCTTTGGATAGTCATAAGCGTGTTCGTTAT
CGTGTGACTCTTATCTATGATGACAACAATGATATCTTAGCCAGTGGCAGTCATCTAGAAGCCAAATCATCAGATGGCAG
TCTAGAGTTCAATGTCTTTATTCCTAATGTTCAAAGCGGTTTGACCTTTGATTATGCAACAGGACAAGTTAAGGCAAATT
AA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (99-251)

3D structure

• AlphaFold DB: Q8DT59

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	64.103	79.863	0.512
endA	Streptococcus pneumoniae D39	64.103	79.863	0.512
endA	Streptococcus pneumoniae R6	64.103	79.863	0.512
endA	Streptococcus pneumoniae TIGR4	64.103	79.863	0.512