Detailed information NTG0022281

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: SAG_RS07760
• Genome accession: NC_004116
• Coordinates: 1016216..1017058 (-)
• Length: 280 a.a.
• NCBI ID: WP_001015240.1
• Uniprot ID: Q8DZU1
• Organism: Streptococcus agalactiae 2603V/R
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1011216..1022058

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAG_RS07750 (SAG1004)	-	1013163..1013864 (-)	702	WP_000120355.1	ABC transporter ATP-binding protein	-
SAG_RS07755 (SAG1005)	topA	1014001..1016121 (-)	2121	WP_000246611.1	type I DNA topoisomerase	-
SAG_RS07760 (SAG1006)	dprA	1016216..1017058 (-)	843	WP_001015240.1	DNA-processing protein DprA	Machinery gene
SAG_RS07765 (SAG1007)	-	1017196..1018224 (-)	1029	WP_000162771.1	siderophore ABC transporter substrate-binding protein	-
SAG_RS07770 (SAG1008)	-	1018286..1019047 (-)	762	WP_000614752.1	ABC transporter ATP-binding protein	-
SAG_RS07775 (SAG1009)	-	1019044..1020018 (-)	975	WP_000588576.1	iron chelate uptake ABC transporter family permease subunit	-
SAG_RS07780 (SAG1010)	-	1020015..1020977 (-)	963	WP_000735588.1	ABC transporter permease	-
SAG_RS07785 (SAG1011)	-	1021216..1021764 (-)	549	WP_000136509.1	sugar O-acetyltransferase	-

Sequence

Protein

• Length: 280 a.a.
• Molecular weight: 31294.36 Da
• Isoelectric Point: 9.3802

>NTDB_id=22281 SAG_RS07760 WP_001015240.1 1016216..1017058(-) (dprA) [Streptococcus agalactiae 2603V/R]
MNHFELFKLKKAGLTNLNIHNIINYLKKNSLTSLSVRNMAVVSKCKNPTFFIENYKQLDLKKLRQEFKKFPVLSILDSNY
PLELKEIYNPPVLLFYQGNIELLSKPKLAVVGARQASQIGCQSVKKIIKETNNQFVIVSGLARGIDTAAHVSALKNGGSS
IAVIGSGLDVYYPTENKKLQEYMSYNHLVLSEYFTGEQPLKFHFPERNRIIAGLCQGIVVAEAKMRSGSLITCERALEEG
REVFAIPGNIIDGKSDGCHHLIQEGAKCIISGKDILSEYQ

Nucleotide

• Length: 843 bp

>NTDB_id=22281 SAG_RS07760 WP_001015240.1 1016216..1017058(-) (dprA) [Streptococcus agalactiae 2603V/R]
ATGAATCATTTTGAACTATTTAAGCTTAAAAAAGCTGGATTAACAAATCTTAATATCCACAATATTATCAACTATCTCAA
AAAGAATAGTTTAACTTCTCTATCTGTTCGCAATATGGCCGTAGTATCAAAATGTAAAAATCCTACTTTCTTTATAGAAA
ATTATAAACAGCTAGACCTTAAAAAACTTCGACAAGAATTCAAAAAATTTCCAGTTCTATCGATTTTGGATTCTAACTAT
CCTTTAGAGTTAAAAGAAATATATAATCCACCAGTTCTACTTTTTTATCAGGGTAATATTGAACTTCTATCTAAACCTAA
ATTAGCTGTAGTGGGGGCAAGACAGGCATCTCAGATAGGTTGTCAGTCTGTTAAAAAGATTATCAAGGAGACTAACAATC
AATTTGTTATCGTAAGTGGTTTAGCGCGTGGCATTGATACAGCAGCACATGTTAGTGCTTTAAAAAATGGCGGCAGTAGT
ATAGCTGTTATCGGGAGTGGTTTAGATGTTTATTATCCAACGGAGAATAAGAAACTTCAAGAATATATGTCATATAATCA
TCTCGTATTATCAGAATATTTTACCGGAGAACAACCCTTGAAATTTCATTTCCCCGAACGTAACCGTATTATTGCAGGGC
TGTGTCAAGGTATTGTGGTTGCCGAAGCTAAGATGAGATCTGGAAGTTTAATTACCTGTGAAAGAGCATTAGAAGAGGGA
CGAGAAGTTTTTGCCATTCCCGGAAATATTATCGATGGCAAATCAGATGGATGCCACCATCTTATCCAAGAAGGAGCTAA
ATGCATTATTTCAGGAAAAGATATCCTTTCTGAATATCAGTAG

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (69-270)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-63)

3D structure

• AlphaFold DB: Q8DZU1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	70.251	99.643	0.7
dprA/cilB/dalA	Streptococcus mitis SK321	62.5	100	0.625
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	61.786	100	0.618
dprA/cilB/dalA	Streptococcus pneumoniae D39	61.786	100	0.618
dprA/cilB/dalA	Streptococcus pneumoniae R6	61.786	100	0.618
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	61.786	100	0.618
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	61.429	100	0.614
dprA	Lactococcus lactis subsp. cremoris KW2	60.932	99.643	0.607
dprA	Latilactobacillus sakei subsp. sakei 23K	42.231	89.643	0.379