Detailed information NTG0022101

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MW_RS09935
• Genome accession: NC_003923
• Coordinates: 1987933..1988976 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus MW2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1982933..1993976

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MW_RS09905 (MW1819)	-	1983361..1984617 (-)	1257	WP_001793428.1	aminopeptidase	-
MW_RS09910 (MW1820)	-	1984620..1984820 (-)	201	WP_000180460.1	DUF1128 family protein	-
MW_RS09915 (MW1821)	-	1984967..1985431 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MW_RS09920 (MW1822)	-	1985438..1985713 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MW_RS09925 (MW1823)	-	1985991..1987202 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
MW_RS09930 (MW1824)	vraR	1987314..1987943 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MW_RS09935 (MW1825)	vraS	1987933..1988976 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MW_RS09940 (MW1826)	liaF	1988973..1989674 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MW_RS09945 (MW1827)	-	1989689..1990075 (-)	387	WP_001110179.1	hypothetical protein	-
MW_RS09950 (MW1828)	map	1990292..1991050 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MW_RS09960 (MW1829)	-	1991581..1992567 (+)	987	WP_000999713.1	FUSC family protein	-
MW_RS09970 (MW1831)	-	1993057..1993470 (-)	414	WP_001837236.1	hypothetical protein	-
MW_RS09975	-	1993499..1993610 (-)	112	Protein_1885	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=22101 MW_RS09935 WP_001017131.1 1987933..1988976(-) (vraS) [Staphylococcus aureus subsp. aureus MW2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=22101 MW_RS09935 WP_001017131.1 1987933..1988976(-) (vraS) [Staphylococcus aureus subsp. aureus MW2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1