Detailed information NTG0220251

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: B4602_RS09870
• Genome accession: NZ_CP020020
• Coordinates: 1935514..1936557 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ATCC 6538
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1930514..1941557

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B4602_RS09840	-	1930936..1932192 (-)	1257	WP_001793428.1	aminopeptidase	-
B4602_RS09845	-	1932195..1932395 (-)	201	WP_000180463.1	DUF1128 family protein	-
B4602_RS09850	-	1932542..1933006 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
B4602_RS09855	-	1933013..1933288 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
B4602_RS09860	-	1933566..1934783 (+)	1218	WP_042727579.1	YihY/virulence factor BrkB family protein	-
B4602_RS09865	vraR	1934895..1935524 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
B4602_RS09870	vraS	1935514..1936557 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
B4602_RS09875	liaF	1936554..1937255 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
B4602_RS09880	-	1937270..1937656 (-)	387	WP_001110179.1	hypothetical protein	-
B4602_RS09885	map	1937873..1938631 (-)	759	WP_000636144.1	type I methionyl aminopeptidase	-
B4602_RS09895	-	1939162..1940148 (+)	987	WP_042727578.1	aromatic acid exporter family protein	-
B4602_RS09905	-	1940638..1941051 (-)	414	WP_001549145.1	hypothetical protein	-
B4602_RS09910	-	1941080..1941190 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=220251 B4602_RS09870 WP_001017131.1 1935514..1936557(-) (vraS) [Staphylococcus aureus strain ATCC 6538]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=220251 B4602_RS09870 WP_001017131.1 1935514..1936557(-) (vraS) [Staphylococcus aureus strain ATCC 6538]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1