Detailed information NTG0220210

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: B4603_RS10210
• Genome accession: NZ_CP020019
• Coordinates: 1994838..1995881 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 08S00974
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1989838..2000881

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B4603_RS10180	-	1990259..1991515 (-)	1257	WP_074347694.1	aminopeptidase	-
B4603_RS10185	-	1991518..1991718 (-)	201	WP_000180460.1	DUF1128 family protein	-
B4603_RS10190	-	1991865..1992329 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
B4603_RS10195	-	1992336..1992611 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
B4603_RS10200	-	1992889..1994106 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
B4603_RS10205	vraR	1994219..1994848 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
B4603_RS10210	vraS	1994838..1995881 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
B4603_RS10215	liaF	1995878..1996579 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
B4603_RS10220	-	1996594..1996980 (-)	387	WP_001110182.1	hypothetical protein	-
B4603_RS10225	map	1997197..1997955 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
B4603_RS10240	-	1998539..1999525 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
B4603_RS10245	-	1999714..2000127 (-)	414	WP_025174370.1	hypothetical protein	-
B4603_RS10250	-	2000156..2000266 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=220210 B4603_RS10210 WP_001017131.1 1994838..1995881(-) (vraS) [Staphylococcus aureus strain 08S00974]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=220210 B4603_RS10210 WP_001017131.1 1994838..1995881(-) (vraS) [Staphylococcus aureus strain 08S00974]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1