Detailed information NTG0021945

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPYM18_RS06695
• Genome accession: NC_003485
• Coordinates: 1283254..1284291 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes MGAS8232
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1278254..1289291

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYM18_RS06675 (spyM18_1549)	-	1278980..1279630 (+)	651	WP_011018007.1	prepilin peptidase	-
SPYM18_RS06680 (spyM18_1550)	rlmN	1279712..1280791 (-)	1080	WP_011018008.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SPYM18_RS06685 (spyM18_1551)	-	1280795..1281415 (-)	621	WP_002992791.1	YutD family protein	-
SPYM18_RS06690 (spyM18_1552)	-	1281863..1282840 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
SPYM18_RS06695 (spyM18_1553)	sepM	1283254..1284291 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
SPYM18_RS06700 (spyM18_1554)	coaD	1284278..1284769 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
SPYM18_RS06705 (spyM18_1555)	rsmD	1284759..1285298 (-)	540	WP_011018010.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPYM18_RS06710 (spyM18_1556)	asnA	1285421..1286413 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
SPYM18_RS06715 (spyM18_1558)	arcC	1286726..1287676 (-)	951	WP_011018011.1	carbamate kinase	-
SPYM18_RS06720 (spyM18_1560)	-	1287696..1289027 (-)	1332	WP_011018012.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=21945 SPYM18_RS06695 WP_010922499.1 1283254..1284291(-) (sepM) [Streptococcus pyogenes MGAS8232]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=21945 SPYM18_RS06695 WP_010922499.1 1283254..1284291(-) (sepM) [Streptococcus pyogenes MGAS8232]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGCGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693