Detailed information NTG0218946

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: B1761_RS07335
• Genome accession: NZ_CP019935
• Coordinates: 1353417..1354934 (+)
• Length: 505 a.a.
• NCBI ID: WP_014607970.1
• Uniprot ID: A0A2H4K9K6
• Organism: Streptococcus thermophilus strain APC151
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 1348417..1359934

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B1761_RS10835 (B1761_07385)	-	1348697..1348867 (+)	171	Protein_1339	ascorbate 6-phosphate lactonase	-
B1761_RS07310 (B1761_07390)	-	1348884..1349555 (-)	672	WP_002946492.1	potassium channel family protein	-
B1761_RS07315 (B1761_07395)	-	1349595..1350959 (-)	1365	WP_014607967.1	TrkH family potassium uptake protein	-
B1761_RS07320 (B1761_07400)	rsmG	1351029..1351742 (-)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
B1761_RS07325 (B1761_07405)	-	1352039..1352575 (+)	537	WP_014607968.1	DUF177 domain-containing protein	-
B1761_RS07330 (B1761_07410)	covR	1352731..1353420 (+)	690	WP_014607969.1	response regulator transcription factor	Regulator
B1761_RS07335 (B1761_07415)	covS	1353417..1354934 (+)	1518	WP_014607970.1	HAMP domain-containing histidine kinase	Regulator
B1761_RS07340 (B1761_07420)	nrdR	1355056..1355535 (+)	480	WP_011680738.1	transcriptional regulator NrdR	-
B1761_RS07345 (B1761_07425)	-	1355532..1356707 (+)	1176	WP_011680739.1	DnaD domain protein	-
B1761_RS07350 (B1761_07430)	dnaI	1356711..1357613 (+)	903	WP_014607971.1	primosomal protein DnaI	-
B1761_RS07355 (B1761_07435)	der	1357719..1359029 (+)	1311	WP_014607972.1	ribosome biogenesis GTPase Der	-
B1761_RS11180	-	1359093..1359752 (+)	660	Protein_1350	HI_0552 family protein	-

Sequence

Protein

• Length: 505 a.a.
• Molecular weight: 57550.96 Da
• Isoelectric Point: 5.2689

>NTDB_id=218946 B1761_RS07335 WP_014607970.1 1353417..1354934(+) (covS) [Streptococcus thermophilus strain APC151]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSIYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide

• Length: 1518 bp

>NTDB_id=218946 B1761_RS07335 WP_014607970.1 1353417..1354934(+) (covS) [Streptococcus thermophilus strain APC151]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTATCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (384-494)

• ArlS sensor domain (ArlS_N) (39-187)

• His Kinase A (phospho-acceptor) domain (HisKA) (270-329)

• HAMP domain (HAMP) (213-265)

3D structure

• AlphaFold DB: A0A2H4K9K6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Streptococcus salivarius strain HSISS4	94.422	99.406	0.939