Detailed information NTG0216760

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: BZK09_RS10090
• Genome accession: NZ_CP019595
• Coordinates: 1983269..1984312 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GD1677
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1978269..1989312

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BZK09_RS10060 (BZK09_10100)	-	1978690..1979946 (-)	1257	WP_001793428.1	aminopeptidase	-
BZK09_RS10065 (BZK09_10105)	-	1979949..1980149 (-)	201	WP_000180460.1	DUF1128 family protein	-
BZK09_RS10070 (BZK09_10110)	-	1980296..1980760 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
BZK09_RS10075 (BZK09_10115)	-	1980767..1981042 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
BZK09_RS10080 (BZK09_10120)	-	1981320..1982537 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
BZK09_RS10085 (BZK09_10125)	vraR	1982650..1983279 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
BZK09_RS10090 (BZK09_10130)	vraS	1983269..1984312 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
BZK09_RS10095 (BZK09_10135)	liaF	1984309..1985010 (-)	702	WP_031886362.1	cell wall-active antibiotics response protein LiaF	-
BZK09_RS10100 (BZK09_10140)	-	1985025..1985411 (-)	387	WP_001110182.1	hypothetical protein	-
BZK09_RS10105 (BZK09_10145)	map	1985628..1986386 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
BZK09_RS10115 (BZK09_10160)	-	1986970..1987956 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
BZK09_RS10120 (BZK09_10165)	-	1988145..1988558 (-)	414	WP_025174370.1	hypothetical protein	-
BZK09_RS10125 (BZK09_10170)	-	1988587..1988697 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=216760 BZK09_RS10090 WP_001017131.1 1983269..1984312(-) (vraS) [Staphylococcus aureus strain GD1677]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=216760 BZK09_RS10090 WP_001017131.1 1983269..1984312(-) (vraS) [Staphylococcus aureus strain GD1677]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1