Detailed information NTG0216716

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: BZK08_RS09975
• Genome accession: NZ_CP019594
• Coordinates: 1951604..1952647 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GD1539
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1946604..1957647

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BZK08_RS09945 (BZK08_10255)	-	1947025..1948281 (-)	1257	WP_001793428.1	aminopeptidase	-
BZK08_RS09950 (BZK08_10260)	-	1948284..1948484 (-)	201	WP_000180460.1	DUF1128 family protein	-
BZK08_RS09955 (BZK08_10265)	-	1948631..1949095 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
BZK08_RS09960 (BZK08_10270)	-	1949102..1949377 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
BZK08_RS09965 (BZK08_10275)	-	1949655..1950872 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
BZK08_RS09970 (BZK08_10280)	vraR	1950985..1951614 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
BZK08_RS09975 (BZK08_10285)	vraS	1951604..1952647 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
BZK08_RS09980 (BZK08_10290)	liaF	1952644..1953345 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
BZK08_RS09985 (BZK08_10295)	-	1953360..1953746 (-)	387	WP_001110182.1	hypothetical protein	-
BZK08_RS09990 (BZK08_10300)	map	1953963..1954721 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
BZK08_RS10000 (BZK08_10310)	-	1955195..1956181 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
BZK08_RS10005 (BZK08_10315)	-	1956370..1956783 (-)	414	WP_025174370.1	hypothetical protein	-
BZK08_RS10010 (BZK08_10320)	-	1956812..1956922 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=216716 BZK08_RS09975 WP_001017131.1 1951604..1952647(-) (vraS) [Staphylococcus aureus strain GD1539]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=216716 BZK08_RS09975 WP_001017131.1 1951604..1952647(-) (vraS) [Staphylococcus aureus strain GD1539]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1