Detailed information NTG0216582

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: BXP64_RS09395
• Genome accession: NZ_CP019591
• Coordinates: 1870713..1871756 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 293G
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1865713..1876756

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BXP64_RS09365 (BXP64_09435)	-	1866134..1867390 (-)	1257	WP_001793428.1	aminopeptidase	-
BXP64_RS09370 (BXP64_09440)	-	1867393..1867593 (-)	201	WP_000180460.1	DUF1128 family protein	-
BXP64_RS09375 (BXP64_09445)	-	1867740..1868204 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
BXP64_RS09380 (BXP64_09450)	-	1868211..1868486 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
BXP64_RS09385 (BXP64_09455)	-	1868764..1869981 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
BXP64_RS09390 (BXP64_09460)	vraR	1870094..1870723 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
BXP64_RS09395 (BXP64_09465)	vraS	1870713..1871756 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
BXP64_RS09400 (BXP64_09470)	liaF	1871753..1872454 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
BXP64_RS09405 (BXP64_09475)	-	1872469..1872855 (-)	387	WP_001110182.1	hypothetical protein	-
BXP64_RS09410 (BXP64_09480)	map	1873072..1873830 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
BXP64_RS09420 (BXP64_09490)	-	1874304..1875290 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
BXP64_RS09425 (BXP64_09495)	-	1875479..1875892 (-)	414	WP_025174370.1	hypothetical protein	-
BXP64_RS09430 (BXP64_09500)	-	1875921..1876031 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=216582 BXP64_RS09395 WP_001017131.1 1870713..1871756(-) (vraS) [Staphylococcus aureus strain 293G]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=216582 BXP64_RS09395 WP_001017131.1 1870713..1871756(-) (vraS) [Staphylococcus aureus strain 293G]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1