Detailed information NTG0216540

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: BJN19_RS10530
• Genome accession: NZ_CP019590
• Coordinates: 2032815..2033858 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain C2406
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2027815..2038858

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BJN19_RS10500 (BJN19_10505)	-	2028233..2029489 (-)	1257	WP_001795438.1	aminopeptidase	-
BJN19_RS10505 (BJN19_10510)	-	2029492..2029692 (-)	201	WP_000180461.1	DUF1128 family protein	-
BJN19_RS10510 (BJN19_10515)	-	2029839..2030303 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
BJN19_RS10515 (BJN19_10520)	-	2030310..2030585 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
BJN19_RS10520 (BJN19_10525)	-	2030863..2032080 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
BJN19_RS10525 (BJN19_10530)	vraR	2032196..2032825 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
BJN19_RS10530 (BJN19_10535)	vraS	2032815..2033858 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
BJN19_RS10535 (BJN19_10540)	liaF	2033855..2034556 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
BJN19_RS10540 (BJN19_10545)	-	2034571..2034957 (-)	387	WP_001110179.1	hypothetical protein	-
BJN19_RS10545 (BJN19_10550)	map	2035174..2035932 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
BJN19_RS10550 (BJN19_10555)	-	2036460..2037446 (+)	987	WP_000999713.1	FUSC family protein	-
BJN19_RS10560 (BJN19_10565)	-	2037936..2038349 (-)	414	WP_001549145.1	hypothetical protein	-
BJN19_RS10565 (BJN19_10570)	-	2038378..2038488 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=216540 BJN19_RS10530 WP_001017131.1 2032815..2033858(-) (vraS) [Staphylococcus aureus strain C2406]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=216540 BJN19_RS10530 WP_001017131.1 2032815..2033858(-) (vraS) [Staphylococcus aureus strain C2406]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1