Detailed information NTG0216358

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: BZP34_RS00755
• Genome accession: NZ_CP019563
• Coordinates: 122109..123152 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SR434
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 117109..128152

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BZP34_RS00720 (BZP34_00720)	-	117594..117704 (+)	111	WP_001790257.1	hypothetical protein	-
BZP34_RS00725 (BZP34_00725)	-	117733..118146 (+)	414	WP_025175030.1	hypothetical protein	-
BZP34_RS00735 (BZP34_00735)	-	118577..119563 (-)	987	WP_000999713.1	FUSC family protein	-
BZP34_RS00740 (BZP34_00740)	map	120035..120793 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
BZP34_RS00745 (BZP34_00745)	-	121010..121396 (+)	387	WP_001110179.1	hypothetical protein	-
BZP34_RS00750 (BZP34_00750)	liaF	121411..122112 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
BZP34_RS00755 (BZP34_00755)	vraS	122109..123152 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
BZP34_RS00760 (BZP34_00760)	vraR	123142..123771 (+)	630	WP_000153532.1	two-component system response regulator VraR	Regulator
BZP34_RS00765 (BZP34_00765)	-	123883..125100 (-)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
BZP34_RS00770 (BZP34_00770)	-	125378..125653 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
BZP34_RS00775 (BZP34_00775)	-	125660..126124 (-)	465	WP_000567539.1	low molecular weight protein-tyrosine-phosphatase	-
BZP34_RS00780 (BZP34_00780)	-	126271..126471 (+)	201	WP_000180460.1	DUF1128 family protein	-
BZP34_RS00785 (BZP34_00785)	-	126474..127730 (+)	1257	WP_072398252.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=216358 BZP34_RS00755 WP_001017131.1 122109..123152(+) (vraS) [Staphylococcus aureus strain SR434]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=216358 BZP34_RS00755 WP_001017131.1 122109..123152(+) (vraS) [Staphylococcus aureus strain SR434]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTGAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1