Detailed information NTG0216293

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: BWR56_RS00355
• Genome accession: NZ_CP019562
• Coordinates: 68111..70543 (+)
• Length: 810 a.a.
• NCBI ID: WP_076984227.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain S.MIT/ORALIS-351
• Function: degradation of ComW (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	51384..72536	68111..70543	within	0

Gene organization within MGE regions

Location: 51384..72536

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BWR56_RS00245 (BWR56_0049)	-	51384..52112 (+)	729	WP_049504541.1	ABC transporter ATP-binding protein	-
BWR56_RS00250 (BWR56_0050)	-	52317..56111 (+)	3795	WP_269466338.1	Spy0128 family protein	-
BWR56_RS00255 (BWR56_0051)	-	56320..57486 (-)	1167	WP_076984224.1	tyrosine-type recombinase/integrase	-
BWR56_RS00260 (BWR56_0052)	-	57837..58808 (-)	972	WP_049540312.1	Abi family protein	-
BWR56_RS00265 (BWR56_0053)	-	58995..59264 (-)	270	WP_004261908.1	DUF4177 domain-containing protein	-
BWR56_RS00270 (BWR56_0054)	-	59270..59836 (-)	567	WP_049490564.1	helix-turn-helix domain-containing protein	-
BWR56_RS00275 (BWR56_0055)	-	60005..60193 (+)	189	WP_049490562.1	hypothetical protein	-
BWR56_RS00280 (BWR56_0056)	-	60357..60959 (+)	603	WP_049490560.1	Rha family transcriptional regulator	-
BWR56_RS00285 (BWR56_0057)	-	60971..61231 (+)	261	WP_049490558.1	hypothetical protein	-
BWR56_RS00295 (BWR56_0058)	-	61567..61767 (+)	201	WP_049490570.1	hypothetical protein	-
BWR56_RS09955	-	61769..61978 (+)	210	WP_049490556.1	hypothetical protein	-
BWR56_RS00305 (BWR56_0059)	-	61980..62252 (+)	273	WP_049490554.1	hypothetical protein	-
BWR56_RS00310 (BWR56_0060)	-	62239..63096 (+)	858	WP_049490552.1	conserved phage C-terminal domain-containing protein	-
BWR56_RS00315 (BWR56_0061)	-	63108..63953 (+)	846	WP_049490551.1	ATP-binding protein	-
BWR56_RS09920 (BWR56_0062)	-	63950..64111 (+)	162	WP_192831374.1	hypothetical protein	-
BWR56_RS00320 (BWR56_0063)	-	64201..64431 (+)	231	WP_049490549.1	hypothetical protein	-
BWR56_RS00325 (BWR56_0064)	-	64481..65341 (+)	861	WP_076984225.1	phage major capsid protein	-
BWR56_RS00330 (BWR56_0065)	-	65351..65899 (+)	549	WP_049539442.1	hypothetical protein	-
BWR56_RS00335 (BWR56_0066)	-	66277..66687 (+)	411	WP_076984226.1	DUF722 domain-containing protein	-
BWR56_RS00340 (BWR56_0067)	-	66826..67170 (+)	345	WP_004261968.1	HK97 gp10 family phage protein	-
BWR56_RS00350 (BWR56_0068)	-	67651..68109 (+)	459	WP_061421536.1	CtsR family transcriptional regulator	-
BWR56_RS00355 (BWR56_0069)	clpC	68111..70543 (+)	2433	WP_076984227.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
BWR56_RS00360 (BWR56_0070)	-	70689..71747 (+)	1059	WP_076984228.1	AAA family ATPase	-
BWR56_RS00365 (BWR56_0071)	pnuC	71757..72536 (+)	780	WP_076984229.1	nicotinamide riboside transporter PnuC	-

Sequence

Protein

• Length: 810 a.a.
• Molecular weight: 90325.09 Da
• Isoelectric Point: 5.9985

>NTDB_id=216293 BWR56_RS00355 WP_076984227.1 68111..70543(+) (clpC) [Streptococcus oralis strain S.MIT/ORALIS-351]
MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGTTLNDYPYEMDRLEEVALELTETDYSQDETFTELPF
SHRLEVLFAEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDQKDQVRIAALRRNLEERAGWTREDLKA
LRQRHRTVSDKQNSMANMMGMPQAQSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGKVILFIDELHTIIGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSLADSMTILQGLKATYEKHHRVQITDEAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKSKHVKADESDLTPADKALMDGKWEQAAQLIAKEEEVPVYKDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRIFEELKKTYRPEFINRIDEKVVFHSLDS
KHMQEIVKIMVKPLIASLAEKGIDLKLQASALKLLASHGYNPEMGARPLRRTLQTEVEDKLAELLLKGELVAGKTLKIGV
KAGQLKFDIA

Nucleotide

• Length: 2433 bp

>NTDB_id=216293 BWR56_RS00355 WP_076984227.1 68111..70543(+) (clpC) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCTGGCCATTTTGGAGCTCGTTATCTAGA
GTCTTGGCATTTATTGATTGCCATGTCCAATCACAGTTATAGTGTGGCAGGTACAACTCTAAATGATTATCCATACGAGA
TGGACCGTTTAGAAGAGGTTGCGTTGGAACTGACTGAAACGGACTATAGCCAAGACGAAACCTTTACGGAATTGCCCTTT
TCCCATCGTTTGGAAGTTCTCTTTGCAGAAGCAGAGTATGTGGCCTCAGTGGTCCACGCAAAGGTGCTAGGGACAGAGCA
TGTTCTCTATGCGATCTTGCATGATGGTAATGCCTTGGCAACTCGCATCTTGGAGAGAGCAGGCTTTTCTTATGAAGACC
AGAAAGATCAGGTCAGAATTGCTGCTCTTCGTCGCAACCTAGAAGAGCGTGCTGGCTGGACTCGTGAAGACCTCAAGGCT
TTGCGTCAACGCCATCGCACAGTATCTGACAAGCAAAATTCCATGGCCAATATGATGGGCATGCCTCAAGCTCAAAGTGG
TGGTCTAGAGGACTACACGCATGACCTGACGGAGCAAGCGCGTTCTGGCAAGTTAGAGCCAGTTATCGGTCGAGACAAGG
AAATCTCACGTATGATTCAAATCTTGAGCCGGAAGACCAAGAACAATCCGGTCTTGGTTGGAGATGCGGGTGTCGGGAAA
ACAGCTTTAGCACTTGGGCTTGCCCAGCGTATTGCTAGTGGGGACGTACCAGCTGAAATGGCCAAGATGCGCGTTTTGGA
GCTTGATTTGATGAATGTCGTTGCAGGGACACGTTTCCGTGGAGATTTTGAAGAGCGCATGAACAATATCATCAAGGACA
TCGAGGAAGACGGCAAAGTGATCCTCTTTATCGATGAACTCCACACCATCATTGGTTCTGGGAGTGGTATTGACTCGACT
CTAGATGCGGCCAATATCTTGAAGCCAGCCTTGGCTCGTGGAACTTTGAGAACGGTTGGTGCCACCACTCAGGAAGAATA
CCAGAAACACATCGAAAAAGATGCTGCCCTTTCTCGTCGGTTTGCCAAAGTGACGATTGAAGAGCCAAGTCTAGCTGACA
GTATGACCATTTTGCAAGGTTTGAAGGCCACCTATGAGAAACACCACCGTGTGCAAATCACAGATGAAGCTGTTGAAACA
GCTGTTAAGATGGCGCATCGTTACTTGACCAGTCGTCACTTGCCAGACTCTGCTATCGACCTCTTAGATGAGGCGGCAGC
AACAGTGCAAAACAAATCCAAGCATGTGAAAGCAGACGAATCCGACTTGACTCCAGCTGACAAGGCCCTGATGGATGGCA
AGTGGGAACAAGCTGCCCAGCTAATCGCAAAAGAAGAGGAAGTTCCTGTCTATAAAGACTTGGTAACAGAATCTGATATT
TTGACCACCTTGAGTCGCTTGTCGGGTATCCCAGTCCAAAAACTGACTCAAACGGATGCCAAGAAATACCTGAATTTGGA
GGCTGAACTACACAAACGTGTCATTGGCCAAGATCAAGCTGTTTCAAGTATTAGCCGTGCCATTCGCCGCAATCAGTCAG
GTATTCGTAGTCACAAGCGTCCGATTGGTTCCTTTATGTTCCTAGGGCCGACAGGAGTCGGTAAGACCGAATTGGCAAAG
GCTCTGGCAGAAGTCCTCTTTGATGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTTGCGGC
TAGCCGTCTCAATGGAGCACCTCCTGGCTATGTGGGCTACGAGGAAGGTGGGGAGTTGACTGAGAAGGTTCGCAACAAAC
CTTACTCAGTGCTTCTCTTTGACGAGGTAGAAAAGGCCCATCCAGACATCTTTAATGTCCTCTTGCAGGTTTTGGACGAC
GGTGTCTTGACAGATAGCAAGGGGCGCAAGGTTGATTTTTCAAATACCATTATCATCATGACGTCAAACCTTGGTGCGAC
GGCTCTTCGTGATGACAAGACTGTTGGCTTTGGCGCGAAAGACATTCGTTTTGACCAGGAAAATATGGAAAAACGCATCT
TCGAAGAGTTGAAAAAAACTTATCGACCAGAGTTTATCAACCGTATTGATGAAAAGGTGGTCTTCCATAGCTTAGATAGC
AAACACATGCAAGAAATTGTTAAGATCATGGTGAAACCATTGATTGCTAGCCTGGCAGAGAAAGGTATCGACTTGAAACT
GCAAGCTTCGGCACTGAAGTTGCTAGCTAGTCACGGTTACAATCCAGAAATGGGAGCTCGCCCACTTCGCAGAACCCTGC
AAACAGAAGTGGAAGACAAGTTGGCAGAACTTCTTCTCAAGGGAGAATTGGTGGCAGGTAAGACACTTAAGATTGGTGTC
AAAGCTGGACAATTGAAATTTGATATTGCTTAA

Domains

Predicted by InterproScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (103-133)

• AAA domain (Cdc48 subfamily) (AAA_2) (540-711)

• ATPase family associated with various cellular activities (AAA) (AAA) (231-362)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (718-797)

• AAA lid domain (AAA_lid_9) (371-446)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae Rx1	96.42	100	0.964
clpC	Streptococcus pneumoniae D39	96.42	100	0.964
clpC	Streptococcus pneumoniae TIGR4	96.42	100	0.964
clpC	Streptococcus mutans UA159	67.528	100	0.678
clpC	Streptococcus thermophilus LMD-9	66.953	100	0.673
clpC	Streptococcus thermophilus LMG 18311	66.83	100	0.672
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.517	100	0.506
clpC	Bacillus subtilis subsp. subtilis str. 168	45.117	99.877	0.451
clpE	Streptococcus mutans UA159	48.871	76.543	0.374
clpC	Lactococcus lactis subsp. cremoris KW2	46.89	77.407	0.363