Detailed information NTG0021552

Bioinformatically predicted

Overview

• Name: micB
• Type: Regulator
• Locus tag: SPR_RS05520
• Genome accession: NC_003098
• Coordinates: 1106262..1107611 (-)
• Length: 449 a.a.
• NCBI ID: WP_000886210.1
• Uniprot ID: A0A064BZM9
• Organism: Streptococcus pneumoniae R6
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1101262..1112611

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPR_RS05500 (spr1102)	-	1102916..1104787 (-)	1872	WP_000150986.1	Eco57I restriction-modification methylase domain-containing protein	-
SPR_RS05505 (spr1103)	-	1104862..1105116 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE family toxin	-
SPR_RS05510 (spr1104)	relB	1105118..1105360 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
SPR_RS05515 (spr1105)	vicX	1105451..1106260 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
SPR_RS05520 (spr1106)	micB	1106262..1107611 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
SPR_RS05525 (spr1107)	micA	1107604..1108308 (-)	705	WP_000722076.1	response regulator YycF	Regulator
SPR_RS05530 (spr1108)	mutY	1108363..1109538 (-)	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
SPR_RS05535 (spr1109)	-	1109867..1111537 (-)	1671	WP_000845292.1	formate--tetrahydrofolate ligase	-
SPR_RS05540 (spr1110)	coaB	1111767..1112456 (+)	690	WP_000699498.1	phosphopantothenate--cysteine ligase	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 51712.42 Da
• Isoelectric Point: 4.9706

>NTDB_id=21552 SPR_RS05520 WP_000886210.1 1106262..1107611(-) (micB) [Streptococcus pneumoniae R6]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide

• Length: 1350 bp

>NTDB_id=21552 SPR_RS05520 WP_000886210.1 1106262..1107611(-) (micB) [Streptococcus pneumoniae R6]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACTAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGCTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTACTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

• PAS fold (PAS) (98-198)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (324-434)

3D structure

• AlphaFold DB: A0A064BZM9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micB	Streptococcus pneumoniae Cp1015	99.777	100	0.998
vicK	Streptococcus mutans UA159	69.9	89.532	0.626