Detailed information NTG0021489

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SP_RS09890
• Genome accession: NC_003028
• Coordinates: 1874849..1875886 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae TIGR4
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1869849..1880886

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP_RS09865 (SP_1963)	-	1870650..1871981 (-)	1332	WP_000390039.1	hemolysin family protein	-
SP_RS09870 (SP_1964)	endA	1872210..1873034 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
SP_RS09875 (SP_1965)	-	1873073..1873261 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
SP_RS09880 (SP_1966)	murA	1873254..1874537 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SP_RS09885	-	1874561..1874791 (-)	231	WP_000250384.1	DUF1146 family protein	-
SP_RS09890 (SP_1967)	sepM	1874849..1875886 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
SP_RS09895 (SP_1968)	coaD	1875870..1876358 (-)	489	WP_001280753.1	pantetheine-phosphate adenylyltransferase	-
SP_RS09900 (SP_1969)	rsmD	1876348..1876887 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SP_RS09905 (SP_1970)	asnA	1876952..1877944 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
SP_RS09915 (SP_1972)	-	1878056..1878739 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
SP_RS09920 (SP_1973)	-	1878795..1879535 (-)	741	WP_000152703.1	TrmH family RNA methyltransferase	-
SP_RS09925 (SP_1974)	-	1879569..1879847 (+)	279	WP_001174612.1	acylphosphatase	-
SP_RS09930 (SP_1975)	yidC	1879925..1880851 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=21489 SP_RS09890 WP_000727277.1 1874849..1875886(-) (sepM) [Streptococcus pneumoniae TIGR4]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=21489 SP_RS09890 WP_000727277.1 1874849..1875886(-) (sepM) [Streptococcus pneumoniae TIGR4]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591