Detailed information NTG0213245

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: BRL61_RS10385
• Genome accession: NZ_CP019117
• Coordinates: 2012799..2013842 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SJTUF_J27
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2007799..2018842

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BRL61_RS10355 (BRL61_10350)	-	2008220..2009476 (-)	1257	WP_001793983.1	aminopeptidase	-
BRL61_RS10360 (BRL61_10355)	-	2009479..2009679 (-)	201	WP_000180460.1	DUF1128 family protein	-
BRL61_RS10365 (BRL61_10360)	-	2009826..2010290 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
BRL61_RS10370 (BRL61_10365)	-	2010297..2010572 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
BRL61_RS10375 (BRL61_10370)	-	2010850..2012067 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
BRL61_RS10380 (BRL61_10375)	vraR	2012180..2012809 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
BRL61_RS10385 (BRL61_10380)	vraS	2012799..2013842 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
BRL61_RS10390 (BRL61_10385)	liaF	2013839..2014540 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
BRL61_RS10395 (BRL61_10390)	-	2014555..2014941 (-)	387	WP_001110178.1	hypothetical protein	-
BRL61_RS10400 (BRL61_10395)	map	2015158..2015916 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
BRL61_RS10420 (BRL61_10415)	-	2016672..2017658 (+)	987	WP_001014423.1	FUSC family protein	-
BRL61_RS10425 (BRL61_10420)	-	2017847..2018260 (-)	414	WP_001643743.1	hypothetical protein	-
BRL61_RS10430 (BRL61_10425)	-	2018289..2018399 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=213245 BRL61_RS10385 WP_001017131.1 2012799..2013842(-) (vraS) [Staphylococcus aureus strain SJTUF_J27]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=213245 BRL61_RS10385 WP_001017131.1 2012799..2013842(-) (vraS) [Staphylococcus aureus strain SJTUF_J27]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1