Detailed information NTG0021288

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SAR_RS10310
• Genome accession: NC_002952
• Coordinates: 2064873..2065916 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus MRSA252
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2059873..2070916

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAR_RS10280 (SAR1969)	-	2060294..2061550 (-)	1257	WP_001793983.1	aminopeptidase	-
SAR_RS10285 (SAR1970)	-	2061553..2061753 (-)	201	WP_000180460.1	DUF1128 family protein	-
SAR_RS10290 (SAR1971)	-	2061900..2062364 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
SAR_RS10295 (SAR1972)	-	2062371..2062646 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SAR_RS10300 (SAR1973)	-	2062924..2064141 (+)	1218	WP_000037085.1	YihY/virulence factor BrkB family protein	-
SAR_RS10305 (SAR1974)	vraR	2064254..2064883 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SAR_RS10310 (SAR1975)	vraS	2064873..2065916 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SAR_RS10315 (SAR1976)	liaF	2065913..2066614 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SAR_RS10320 (SAR1977)	-	2066629..2067015 (-)	387	WP_001110178.1	hypothetical protein	-
SAR_RS10325 (SAR1978)	map	2067232..2067990 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SAR_RS10330 (SAR1980)	-	2068690..2069676 (+)	987	WP_001014423.1	FUSC family protein	-
SAR_RS10335 (SAR1981)	-	2069865..2070278 (-)	414	WP_001643743.1	hypothetical protein	-
SAR_RS10340	-	2070307..2070417 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=21288 SAR_RS10310 WP_001017131.1 2064873..2065916(-) (vraS) [Staphylococcus aureus subsp. aureus MRSA252]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=21288 SAR_RS10310 WP_001017131.1 2064873..2065916(-) (vraS) [Staphylococcus aureus subsp. aureus MRSA252]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1