Detailed information NTG0021245

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SACOL_RS10160
• Genome accession: NC_002951
• Coordinates: 2005560..2006603 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus COL
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2000560..2011603

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SACOL_RS10130 (SA1937)	-	2000978..2002234 (-)	1257	WP_001795438.1	aminopeptidase	-
SACOL_RS10135 (SA1938)	-	2002237..2002437 (-)	201	WP_000180461.1	DUF1128 family protein	-
SACOL_RS10140 (SA1939)	-	2002584..2003048 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SACOL_RS10145 (SA1940)	-	2003055..2003330 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SACOL_RS10150 (SA1941)	-	2003608..2004825 (+)	1218	WP_000037073.1	YihY/virulence factor BrkB family protein	-
SACOL_RS10155 (SA1942)	vraR	2004941..2005570 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SACOL_RS10160 (SA1943)	vraS	2005560..2006603 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SACOL_RS10165 (SA1944)	liaF	2006600..2007301 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SACOL_RS10170 (SA1945)	-	2007316..2007702 (-)	387	WP_001110179.1	hypothetical protein	-
SACOL_RS10175 (SA1946)	map	2007919..2008677 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SACOL_RS10185 (SA1947)	-	2009205..2010191 (+)	987	WP_000999713.1	FUSC family protein	-
SACOL_RS10190 (SA1948)	-	2010622..2011035 (-)	414	WP_001549145.1	hypothetical protein	-
SACOL_RS10195 (SA1949)	-	2011064..2011174 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=21245 SACOL_RS10160 WP_001017131.1 2005560..2006603(-) (vraS) [Staphylococcus aureus subsp. aureus COL]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=21245 SACOL_RS10160 WP_001017131.1 2005560..2006603(-) (vraS) [Staphylococcus aureus subsp. aureus COL]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1