Detailed information NTG0021074

Bioinformatically predicted

Overview

• Name: pilC
• Type: Machinery gene
• Locus tag: HD_RS04635
• Genome accession: NC_002940
• Coordinates: 894354..895547 (+)
• Length: 397 a.a.
• NCBI ID: WP_010945037.1
• Uniprot ID: Q7VM72
• Organism: [Haemophilus] ducreyi 35000HP
• Function: type IV pilus biogenesis and function (predicted from homology) DNA binding and uptake

Genomic Context

Location: 889354..900547

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HD_RS04610 (HD1118)	-	890053..890538 (+)	486	WP_010945031.1	dihydrofolate reductase	-
HD_RS04615 (HD1120)	-	890660..890875 (+)	216	WP_010945033.1	YgjV family protein	-
HD_RS04620 (HD1121)	radA	890942..892321 (-)	1380	WP_010945034.1	DNA repair protein RadA	-
HD_RS04625 (HD1123)	pilA	892515..892964 (+)	450	WP_010945035.1	prepilin peptidase-dependent pilin	Machinery gene
HD_RS04630 (HD1124)	pilB	892976..894370 (+)	1395	WP_010945036.1	GspE/PulE family protein	Machinery gene
HD_RS04635 (HD1125)	pilC	894354..895547 (+)	1194	WP_010945037.1	type II secretion system F family protein	Machinery gene
HD_RS04640 (HD1126)	-	895547..896239 (+)	693	WP_041603480.1	prepilin peptidase	-
HD_RS04645 (HD1127)	coaE	896257..896874 (+)	618	WP_010945039.1	dephospho-CoA kinase	-
HD_RS04650 (HD1129)	yacG	896877..897065 (+)	189	WP_010945040.1	DNA gyrase inhibitor YacG	-
HD_RS04655 (HD1130)	holA	897099..898124 (-)	1026	WP_010945041.1	DNA polymerase III subunit delta	-
HD_RS04660 (HD1131)	lptE	898130..898627 (-)	498	WP_010945042.1	LPS assembly lipoprotein LptE	-

Sequence

Protein

• Length: 397 a.a.
• Molecular weight: 45721.33 Da
• Isoelectric Point: 10.1310

>NTDB_id=21074 HD_RS04635 WP_010945037.1 894354..895547(+) (pilC) [[Haemophilus] ducreyi 35000HP]
MLKIYEFHWRAFNRFNQRQKGKSLAKSHDELEQRLLAKGYSNIHIQRNFILVRKPKSEQITQLINQLAMLLNASVPLKQS
LVMVLENVHNIKLYLWLSEIIMLLEAGHAFSASLTKMNVYLTKQEIQLIQMGEQSGRLAIMLDNIAQVRNQSQKLANKVK
KIMFYPAIILAVSISVLIGLLLFIVPQFEDLYRNKDQSLPFITQLLFQLSNFLQQYAFILFIGGLFSGIVSYFLAKKWLF
WRTLRSRLLNHMPGFQQIIKDARIIFFSQNLALMLNAHIHLDATLKAFLSEHRQDPVLHQEILSILSLLKQGYKFSEGLN
PTVFTSQVVQMMAIGEQSGNLAKMCMYISQLYQQKLDYQIDLFAQLLEPVLMVVIGIIVGTILIGIYLPIFDMGALV

Nucleotide

• Length: 1194 bp

>NTDB_id=21074 HD_RS04635 WP_010945037.1 894354..895547(+) (pilC) [[Haemophilus] ducreyi 35000HP]
ATGCTGAAAATATATGAATTTCATTGGCGGGCTTTTAATCGTTTTAATCAACGGCAAAAAGGTAAATCTCTGGCCAAAAG
TCACGATGAATTAGAACAACGGCTATTAGCTAAAGGCTATTCAAATATCCATATTCAACGTAATTTTATTTTAGTTAGGA
AACCAAAAAGCGAACAAATCACTCAATTAATTAATCAGTTAGCTATGTTATTGAATGCCTCGGTTCCATTAAAACAATCG
CTGGTGATGGTATTAGAAAACGTACATAATATTAAATTATATTTATGGCTATCTGAAATTATTATGCTGTTAGAAGCGGG
GCATGCTTTTTCAGCCAGTCTCACTAAAATGAACGTTTATTTGACTAAGCAAGAAATTCAGTTAATTCAGATGGGAGAAC
AGAGTGGGCGTTTAGCCATTATGCTAGATAACATTGCACAAGTACGTAATCAATCACAGAAATTAGCTAATAAAGTAAAG
AAAATTATGTTTTATCCGGCGATTATTTTAGCCGTATCAATTAGTGTATTAATTGGATTGTTATTATTTATTGTGCCTCA
ATTTGAAGATCTTTATCGTAACAAAGATCAGTCACTGCCTTTTATTACCCAATTATTATTTCAGTTATCGAATTTTCTTC
AACAATATGCATTTATTTTATTCATCGGCGGCCTATTTAGCGGTATTGTTAGCTATTTTTTAGCGAAAAAGTGGCTTTTT
TGGCGTACCTTAAGATCGCGTTTATTAAATCATATGCCAGGGTTTCAGCAAATTATTAAAGATGCTCGAATTATTTTCTT
TAGTCAAAATCTTGCGTTAATGCTTAATGCACATATTCATTTAGATGCAACGTTAAAAGCATTTTTATCAGAACATCGCC
AAGATCCGGTATTACATCAGGAGATTTTGAGTATATTAAGTTTATTAAAGCAAGGTTATAAATTCTCTGAGGGGCTTAAT
CCAACCGTATTTACTAGCCAAGTAGTACAAATGATGGCAATTGGCGAACAAAGTGGTAATTTGGCTAAAATGTGTATGTA
TATTAGTCAACTGTATCAGCAAAAACTGGATTACCAAATTGATTTGTTTGCTCAATTACTTGAACCGGTTTTAATGGTAG
TGATTGGCATTATTGTGGGGACGATTTTGATTGGGATTTATTTGCCTATTTTTGATATGGGAGCATTGGTGTAA

Domains

Predicted by InterproScan.

• Type II secretion system (T2SS), protein F (T2SSF) (64-186)

• Type II secretion system (T2SS), protein F (T2SSF) (267-389)

3D structure

• AlphaFold DB: Q7VM72

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pilC	Glaesserella parasuis strain SC1401	51.637	100	0.516
pilC	Haemophilus influenzae Rd KW20	40.75	100	0.411
pilC	Haemophilus influenzae 86-028NP	40.25	100	0.406