Detailed information    

insolico Bioinformatically predicted

Overview

Name   endA   Type   Machinery gene
Locus tag   BSR14_RS05370 Genome accession   NZ_CP018186
Coordinates   1203885..1204766 (-) Length   293 a.a.
NCBI ID   WP_149561298.1    Uniprot ID   A0AB37CL97
Organism   Streptococcus salivarius strain ICDC1     
Function   cleavage of dsDNA into ssDNA (predicted from homology)   
DNA processing

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1191065..1203807 1203885..1204766 flank 78


Gene organization within MGE regions


Location: 1191065..1204766
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BSR14_RS05285 (BSR14_05340) - 1191065..1191742 (+) 678 WP_045771627.1 helix-turn-helix domain-containing protein -
  BSR14_RS10340 (BSR14_05345) - 1191739..1192704 (+) 966 WP_045771628.1 IS3 family transposase -
  BSR14_RS05300 (BSR14_05350) tnpA 1192977..1193393 (-) 417 WP_002886752.1 IS200/IS605 family transposase -
  BSR14_RS05305 (BSR14_05355) - 1193631..1193907 (-) 277 Protein_993 ISL3 family transposase -
  BSR14_RS05310 (BSR14_05360) - 1194079..1194438 (-) 360 WP_156209757.1 YbaN family protein -
  BSR14_RS05315 (BSR14_05365) vicX 1194497..1195309 (-) 813 WP_002885031.1 MBL fold metallo-hydrolase Regulator
  BSR14_RS05320 (BSR14_05370) vicK 1195315..1196655 (-) 1341 WP_002885062.1 cell wall metabolism sensor histidine kinase VicK Regulator
  BSR14_RS05325 (BSR14_05375) vicR 1196648..1197355 (-) 708 WP_049554316.1 response regulator YycF Regulator
  BSR14_RS05330 (BSR14_05380) - 1197641..1198408 (+) 768 WP_038675884.1 amino acid ABC transporter ATP-binding protein -
  BSR14_RS05335 (BSR14_05385) - 1198418..1199251 (+) 834 WP_156209759.1 transporter substrate-binding domain-containing protein -
  BSR14_RS05340 (BSR14_05390) - 1199269..1199967 (+) 699 WP_014633207.1 amino acid ABC transporter permease -
  BSR14_RS05345 (BSR14_05395) - 1199979..1200629 (+) 651 WP_002886253.1 amino acid ABC transporter permease -
  BSR14_RS05350 (BSR14_05400) - 1200817..1201584 (+) 768 WP_038675884.1 amino acid ABC transporter ATP-binding protein -
  BSR14_RS05355 (BSR14_05405) - 1201596..1202429 (+) 834 WP_111686600.1 transporter substrate-binding domain-containing protein -
  BSR14_RS05360 (BSR14_05410) - 1202447..1203145 (+) 699 WP_014633207.1 amino acid ABC transporter permease -
  BSR14_RS05365 (BSR14_05415) - 1203157..1203807 (+) 651 WP_002886253.1 amino acid ABC transporter permease -
  BSR14_RS05370 (BSR14_05420) endA 1203885..1204766 (-) 882 WP_149561298.1 DNA/RNA non-specific endonuclease Machinery gene

Sequence

Protein


Download         Length: 293 a.a.        Molecular weight: 31503.13 Da        Isoelectric Point: 10.2703

>NTDB_id=206789 BSR14_RS05370 WP_149561298.1 1203885..1204766(-) (endA) [Streptococcus salivarius strain ICDC1]
MAKRKTSLTNKQKRQLVSLLIAVLIAVLGYIGTSNKLSPNNPIKQVASLVSGKSNNSAKSNGSTSGQSTPQEQLAETVMT
SSVKSQLGNAIEWNGAGAYIVNGNKTNLNAKVSSQPYANNQVKTVQGQTVPTVANALLSKATRQYKNRQETGNGSTSWTP
AGWHQVHNLSGEYNHAVDRGHLLGYALVGGLKGFDASTSNPENIAVQTAWANQANSETSTGQNYYESLVRKAQDKNKRVR
YRVTLIYEGDNLIPSGSHLEAKSADGSLEFNVFVPNVQKGITLDYYSGKVTVN

Nucleotide


Download         Length: 882 bp        

>NTDB_id=206789 BSR14_RS05370 WP_149561298.1 1203885..1204766(-) (endA) [Streptococcus salivarius strain ICDC1]
ATGGCAAAAAGAAAGACATCTTTAACAAATAAACAGAAACGTCAGCTAGTCTCGTTACTAATAGCGGTTTTGATTGCAGT
TTTAGGTTACATTGGAACGAGTAATAAACTCTCACCTAACAATCCAATCAAGCAGGTAGCTAGTCTAGTCTCGGGAAAAT
CCAATAACTCCGCCAAATCAAACGGCTCAACAAGTGGGCAGTCTACGCCACAAGAGCAACTCGCAGAGACAGTGATGACC
AGCTCCGTCAAGAGTCAACTAGGAAACGCCATAGAATGGAATGGGGCTGGTGCCTATATTGTTAACGGTAATAAAACCAA
TCTTAATGCTAAGGTATCTAGCCAACCCTATGCTAATAACCAAGTTAAAACGGTTCAAGGACAAACCGTTCCTACAGTTG
CGAATGCCTTGTTAAGTAAAGCGACTAGACAGTACAAAAATCGTCAAGAAACAGGGAATGGCTCAACTTCTTGGACACCA
GCTGGATGGCATCAAGTTCACAATCTTTCAGGAGAGTATAACCATGCCGTAGACCGAGGCCATTTGTTAGGTTATGCACT
TGTAGGTGGCCTCAAAGGATTTGATGCCTCGACTTCAAATCCAGAGAATATTGCTGTTCAAACTGCTTGGGCTAACCAAG
CTAATAGTGAAACTTCCACAGGCCAAAACTATTATGAAAGCCTGGTACGAAAAGCTCAGGATAAAAACAAACGTGTCCGT
TACCGCGTGACTCTCATTTATGAAGGAGATAACCTGATTCCATCAGGATCACATCTTGAAGCCAAGTCAGCAGATGGCTC
GCTTGAGTTCAATGTCTTCGTTCCAAATGTCCAAAAGGGAATTACCCTAGATTATTATTCAGGGAAAGTAACGGTGAATT
AA

Domains

Predicted by InterproScan.

DNA/RNA non-specific endonuclease (Endonuclease_NS)

(99-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  endA Streptococcus pneumoniae Rx1

70.751

86.348

0.611
  endA Streptococcus pneumoniae D39

70.751

86.348

0.611
  endA Streptococcus pneumoniae R6

70.751

86.348

0.611
  endA Streptococcus pneumoniae TIGR4

70.751

86.348

0.611

Multiple sequence alignment