Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   Spy49_1254c Genome accession   CP000829
Coordinates   1260179..1260820 (-) Length   213 a.a.
NCBI ID   ACI61539.1    Uniprot ID   -
Organism   Streptococcus pyogenes NZ131     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1255179..1265820
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Spy49_1249c comFA/cflA 1255265..1256590 (-) 1326 ACI61534.1 Putative late competence protein required for DNA uptake Machinery gene
  Spy49_1250 - 1256646..1257278 (+) 633 ACI61535.1 Conserved hypothetical protein -
  Spy49_1251 cysM 1257406..1258347 (+) 942 ACI61536.1 Cysteine synthase A -
  Spy49_1252c - 1258365..1258742 (-) 378 ACI61537.1 Putative polyribonucleotide nucleotidyltransferase -
  Spy49_1253c - 1258742..1260142 (-) 1401 ACI61538.1 Hydrolase, haloacid dehalogenase family/peptidyl-prolyl cis-trans isomerase, cyclophilin type -
  Spy49_1254c vraR 1260179..1260820 (-) 642 ACI61539.1 Putative two-component response regulator Regulator
  Spy49_1255c - 1260813..1261817 (-) 1005 ACI61540.1 Putative two-component sensor histidine kinase -
  Spy49_1256c - 1261814..1262506 (-) 693 ACI61541.1 Conserved hypothetical protein -
  Spy49_1257c pknB 1262629..1264527 (-) 1899 ACI61542.1 Serine/threonine protein kinase Regulator
  Spy49_1259c pppL 1264524..1265264 (-) 741 ACI61543.1 Putative phosphoprotein phosphatase (pppL protein) -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=20282 Spy49_1254c ACI61539.1 1260179..1260820(-) (vraR) [Streptococcus pyogenes NZ131]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=20282 Spy49_1254c ACI61539.1 1260179..1260820(-) (vraR) [Streptococcus pyogenes NZ131]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCTAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment