Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   Spy49_1112c Genome accession   CP000829
Coordinates   1108168..1109973 (-) Length   601 a.a.
NCBI ID   ACI61404.1    Uniprot ID   -
Organism   Streptococcus pyogenes NZ131     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1087871..1134962 1108168..1109973 within 0


Gene organization within MGE regions


Location: 1087871..1134962
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Spy49_1092c - 1087909..1089183 (-) 1275 ACI61385.1 Polysaccharide deacetylase family protein -
  Spy49_1093c gapN 1089304..1090707 (-) 1404 ACI61386.1 Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP) -
  Spy49_1094c ptsI 1090892..1092625 (-) 1734 ACI61387.1 Phosphoenolpyruvate-protein phosphotransferase of PTS system -
  Spy49_1095c ptsH 1092630..1092893 (-) 264 ACI61388.1 Phosphocarrier protein of PTS system -
  Spy49_1096 nrdH 1093253..1093504 (+) 252 ACI61389.1 Putative glutaredoxin -
  Spy49_1097 nrdE1 1093524..1095683 (+) 2160 ACI61390.1 Ribonucleotide reductase of class Ib (aerobic), alpha subunit -
  Spy49_1098 nrdF1 1095664..1095981 (+) 318 ACI61391.1 hypothetical protein -
  Spy49_1099 - 1096016..1096975 (+) 960 ACI61392.1 Ribonucleotide reductase of class Ib (aerobic), beta subunit -
  Spy49_1100 - 1096950..1098263 (+) 1314 ACI61393.1 Putative chloride channel protein -
  Spy49_1101 - 1098401..1098694 (+) 294 ACI61394.1 hypothetical protein -
  Spy49_1103 - 1099127..1099297 (+) 171 ACI61395.1 Transposase -
  Spy49_1104 - 1099337..1099558 (+) 222 ACI61396.1 Transposase -
  Spy49_1105c - 1099651..1100346 (-) 696 ACI61397.1 hypothetical protein -
  Spy49_1106c - 1100365..1101126 (-) 762 ACI61398.1 hypothetical protein -
  Spy49_1107c - 1101123..1101353 (-) 231 ACI61399.1 Transcriptional regulator, Cro/CI family -
  Spy49_1108c alaS 1101699..1104317 (-) 2619 ACI61400.1 Alanyl-tRNA synthetase -
  Spy49_1109c prtM1 1104704..1105759 (-) 1056 ACI61401.1 Foldase protein prsA 1 precursor -
  Spy49_1110c - 1105822..1106529 (-) 708 ACI61402.1 Putative methyltransferase -
  Spy49_1111c - 1106595..1107791 (-) 1197 ACI61403.1 Putative oxalate:formate antiporter -
  Spy49_1112c pepF 1108168..1109973 (-) 1806 ACI61404.1 Group B oligopeptidase pepB Regulator
  Spy49_1113c - 1109986..1110948 (-) 963 ACI61405.1 Putative transcription factor -
  Spy49_1114c - 1111245..1111961 (-) 717 ACI61406.1 Putative 16S pseudouridylate synthetase -
  Spy49_1115c nagB 1112080..1112784 (-) 705 ACI61407.1 Glucosamine-6-phosphate deaminase -
  Spy49_1116 queA 1112986..1114014 (+) 1029 ACI61408.1 S-adenosylmethionine:tRNA ribosyltransferase- isomerase -
  Spy49_1117 - 1114021..1115241 (+) 1221 ACI61409.1 Conserved hypothetical protein -
  Spy49_1119c - 1115355..1115945 (-) 591 ACI61410.1 hypothetical protein -
  Spy49_1120c - 1115942..1116190 (-) 249 ACI61411.1 hypothetical protein -
  Spy49_1121c - 1116175..1116402 (-) 228 ACI61412.1 hypothetical protein -
  Spy49_1122c sodM 1116524..1117168 (-) 645 ACI61413.1 Superoxide dismutase (Mn) -
  Spy49_1123c holA 1117265..1118305 (-) 1041 ACI61414.1 DNA polymerase III delta subunit -
  Spy49_1124c comEC 1118376..1120619 (-) 2244 ACI61415.1 DNA internalization-related competence protein ComEC/Rec2 -
  Spy49_1126c comE 1120600..1121262 (-) 663 ACI61416.1 Putative competence protein -
  Spy49_1127c - 1121462..1122202 (-) 741 ACI61417.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  Spy49_1128 - 1122242..1123096 (+) 855 ACI61418.1 Conserved hypothetical protein -
  Spy49_1129 - 1123086..1123364 (+) 279 ACI61419.1 Conserved hypothetical protein -
  Spy49_1130c kup 1123388..1125388 (-) 2001 ACI61420.1 Potassium uptake protein, putative -
  Spy49_1132c deaD1 1125516..1127135 (-) 1620 ACI61421.1 Putative ATP-dependent RNA helicase -
  Spy49_1133c prfC 1127442..1128986 (-) 1545 ACI61422.1 Peptide chain release factor 3 -
  Spy49_1135c - 1129234..1129929 (-) 696 ACI61423.1 hypothetical protein -
  Spy49_1136c murF 1130009..1131400 (-) 1392 ACI61424.1 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D- alanine ligase -
  Spy49_1137c ddlA 1131591..1132637 (-) 1047 ACI61425.1 D-alanine--D-alanine ligase -
  Spy49_1138c recR 1132738..1133334 (-) 597 ACI61426.1 Recombination protein recR -
  Spy49_1139c - 1133381..1133572 (-) 192 ACI61427.1 hypothetical protein -
  Spy49_1140c fdhC 1134132..1134947 (-) 816 ACI61428.1 Formate/nitrite transporter family member -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69434.51 Da        Isoelectric Point: 4.8042

>NTDB_id=20150 Spy49_1112c ACI61404.1 1108168..1109973(-) (pepF) [Streptococcus pyogenes NZ131]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENIELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDYYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=20150 Spy49_1112c ACI61404.1 1108168..1109973(-) (pepF) [Streptococcus pyogenes NZ131]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACATTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATTATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

70.549

100

0.705

Multiple sequence alignment