Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   WH25_RS04295 Genome accession   NZ_CP017295
Coordinates   884854..887115 (-) Length   753 a.a.
NCBI ID   WP_046165885.1    Uniprot ID   -
Organism   Streptococcus gordonii strain IE35     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 879854..892115
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WH25_RS04265 (WH25_04265) - 881287..881742 (-) 456 WP_046165890.1 MarR family winged helix-turn-helix transcriptional regulator -
  WH25_RS04270 (WH25_04270) - 881765..882202 (+) 438 WP_046165889.1 GNAT family N-acetyltransferase -
  WH25_RS04275 (WH25_04275) - 882239..882538 (-) 300 WP_045773849.1 DUF1827 family protein -
  WH25_RS04280 (WH25_04280) - 882637..883089 (-) 453 WP_046165888.1 NUDIX hydrolase -
  WH25_RS04285 (WH25_04285) - 883248..884138 (+) 891 WP_046165887.1 helix-turn-helix transcriptional regulator -
  WH25_RS04290 (WH25_04290) - 884198..884803 (+) 606 WP_046165886.1 GyrI-like domain-containing protein -
  WH25_RS04295 (WH25_04295) clpE 884854..887115 (-) 2262 WP_046165885.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  WH25_RS04300 (WH25_04300) - 887368..887598 (+) 231 WP_008809091.1 DUF1797 family protein -
  WH25_RS04305 (WH25_04305) - 887731..888585 (+) 855 WP_046165884.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  WH25_RS04310 (WH25_04310) - 888582..889355 (+) 774 WP_046165883.1 HAD hydrolase family protein -
  WH25_RS04315 (WH25_04315) - 889463..890305 (+) 843 WP_046165882.1 NAD(P)H-hydrate dehydratase -
  WH25_RS04320 (WH25_04320) xseA 890461..891801 (+) 1341 WP_046165881.1 exodeoxyribonuclease VII large subunit -
  WH25_RS04325 (WH25_04325) - 891779..891991 (+) 213 WP_008809086.1 exodeoxyribonuclease VII small subunit -

Sequence

Protein


Download         Length: 753 a.a.        Molecular weight: 83944.04 Da        Isoelectric Point: 5.0247

>NTDB_id=197412 WH25_RS04295 WP_046165885.1 884854..887115(-) (clpE) [Streptococcus gordonii strain IE35]
MLCQNCKINESTIHLYTNVNGKKQQVDLCQNCYQIMKTDPNNSLLGGLTNMNNHNMDPFDDFFNHLGNFQGPKDSTPPTQ
SGGSYGGGNYGPGSNNQRPQSASNKPKGLLEEFGINVTEIARRGDIDPVIGRDDEIRRVIEILNRRTKNNPVLIGEPGVG
KTAVVEGLAQKIVDNDVPQKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRNRNDIILFIDEIHEIVGAGSAGDG
NMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVRYTDEAIEA
AAILSNRYIQDRFLPDKAIDLLDESGSKMNLTLNFVDPKEIDRRLIEAENLKTQATRDEDYEKAAYFRDQIAKYKEMQNA
KMDEQDTPIISEKEIEAIVEQKTNIPVGDLKEKEQSQLIHLASDLKSHVIGQDDAVDKIAKAIRRNRVGLGSPNRPIGSF
LFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYEEAGQLTERVRRNPYSLILLDEVEK
AHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAREGRTNSVLGELGNFFSPEFMNRFDGI
IEFKALSKDNLLQIVDLMLEDVNNRLASNEIHLDVTAKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDYYLEHPTDK
DLKAIMTSNGKIIIKGKKKAELDQTTDISTSSD

Nucleotide


Download         Length: 2262 bp        

>NTDB_id=197412 WH25_RS04295 WP_046165885.1 884854..887115(-) (clpE) [Streptococcus gordonii strain IE35]
ATGCTTTGTCAAAACTGTAAAATCAATGAATCTACCATTCATTTATACACTAATGTAAATGGTAAAAAACAACAAGTTGA
CCTCTGTCAAAATTGCTATCAGATTATGAAAACTGATCCAAATAACTCACTTTTGGGTGGACTGACGAACATGAATAATC
ATAATATGGATCCTTTTGATGATTTCTTTAATCATCTGGGAAATTTCCAAGGGCCGAAGGATTCTACCCCTCCAACTCAA
TCAGGTGGTAGTTATGGAGGGGGCAACTATGGTCCTGGTTCTAACAACCAGCGTCCTCAGTCAGCCTCCAATAAACCAAA
AGGTCTTTTGGAAGAGTTTGGCATTAACGTTACAGAAATTGCTCGACGTGGTGATATTGATCCAGTGATTGGACGAGATG
ATGAAATTCGTCGTGTTATAGAAATTCTCAATCGCCGAACTAAGAATAACCCAGTCCTTATTGGTGAACCTGGTGTCGGG
AAGACTGCTGTTGTAGAGGGCTTGGCACAGAAAATAGTCGACAATGATGTCCCTCAAAAACTTCAAGGAAAAGAGGTCAT
TCGACTTGATGTTGTCAGCCTTGTTCAAGGAACTGGTATTCGTGGGCAATTTGAAGAACGAATGCAAAAACTCATGGATG
AGATTCGCAATCGCAATGACATCATTCTCTTTATTGATGAAATCCATGAAATTGTTGGAGCTGGCTCTGCGGGCGACGGT
AATATGGATGCTGGAAATATTCTCAAACCTGCTCTTGCTCGAGGTGAACTTCAACTGGTCGGAGCTACTACTCTCAATGA
ATACCGAATCATTGAAAAAGATGCAGCATTAGAAAGACGGATGCAACCAGTCAAAGTAGATGAACCAACCGTAGAAGAAA
CGATCACAATTCTAAAGGGGATTCAAAAGAAATACGAAGATTACCACCATGTTCGCTACACAGATGAAGCTATTGAAGCT
GCTGCCATCCTATCCAATCGTTATATTCAGGACCGTTTCCTTCCCGATAAAGCTATTGATCTTTTGGATGAATCAGGATC
TAAGATGAACCTAACCCTCAATTTTGTTGATCCAAAAGAAATTGACAGACGCTTGATAGAGGCTGAAAATCTGAAAACAC
AGGCCACTCGCGATGAAGATTACGAAAAAGCAGCCTACTTCCGCGACCAAATTGCCAAATATAAGGAAATGCAAAATGCT
AAAATGGATGAACAAGATACTCCTATCATCAGTGAGAAGGAGATCGAAGCTATTGTCGAGCAAAAAACAAATATTCCTGT
TGGTGATTTGAAGGAAAAAGAGCAGTCTCAGCTTATTCATTTAGCTAGTGATTTGAAGTCTCATGTCATTGGTCAGGATG
ATGCTGTTGATAAGATTGCAAAAGCCATCCGTCGTAATCGTGTGGGATTAGGCAGTCCAAACCGGCCAATCGGAAGTTTC
CTTTTTGTTGGACCGACAGGCGTTGGAAAAACTGAACTTTCCAAACAATTGGCCATCGAACTTTTTGGCTCTGCCGATAG
CATGATTCGTTTTGATATGAGTGAATACATGGAAAAACATAGCGTTGCCAAACTTGTAGGAGCACCTCCAGGCTACGTTG
GCTATGAAGAAGCAGGCCAGTTGACTGAACGTGTTCGTCGTAATCCATACTCACTCATTCTCTTAGACGAAGTAGAAAAA
GCCCATCCAGATGTCATGCATATGTTCTTACAAGTCTTAGATGACGGACGTTTGACTGATGGACAAGGTCGAACAGTCAG
CTTCAAAGATACCATTATCATTATGACTTCCAATGCAGGAACCGGTAAAGTGGAAGCAAGCGTTGGTTTTGGAGCCGCCC
GAGAAGGTCGAACAAATTCTGTCTTAGGTGAGTTAGGTAACTTCTTTAGTCCAGAATTCATGAACCGATTTGATGGTATT
ATTGAATTCAAGGCATTAAGCAAGGACAATCTCTTACAAATTGTGGATCTAATGCTGGAAGATGTTAATAATCGACTTGC
TAGCAACGAAATTCATCTAGATGTAACAGCTAAAGTCAAAGAAAAATTGGTTGATCTGGGCTACGATCCTAAGATGGGGG
CACGACCACTCCGCAGAACCATTCAGGACCATATCGAAGATGCTATTACGGACTACTACCTAGAACATCCGACAGATAAG
GATTTAAAAGCAATTATGACTAGCAATGGCAAGATTATAATTAAGGGGAAAAAGAAAGCTGAGCTTGATCAAACAACCGA
CATCAGCACAAGCTCAGATTAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(152-271)

AAA lid domain (AAA_lid_9)

(290-387)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(646-718)

AAA domain (Cdc48 subfamily) (AAA_2)

(475-638)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

86.729

99.07

0.859
  clpE Streptococcus pneumoniae D39

86.729

99.07

0.859
  clpE Streptococcus pneumoniae R6

86.729

99.07

0.859
  clpE Streptococcus pneumoniae TIGR4

86.595

99.07

0.858
  clpE Streptococcus mutans UA159

85.121

99.07

0.843
  clpC Lactococcus lactis subsp. cremoris KW2

77.321

100

0.774
  clpC Bacillus subtilis subsp. subtilis str. 168

50.74

89.774

0.456
  clpC Streptococcus pneumoniae D39

47.84

83.001

0.397
  clpC Streptococcus pneumoniae Rx1

47.84

83.001

0.397
  clpC Streptococcus pneumoniae TIGR4

47.68

83.001

0.396
  clpC Streptococcus mutans UA159

46.406

84.993

0.394
  clpC Streptococcus thermophilus LMD-9

44.985

87.384

0.393
  clpC Streptococcus thermophilus LMG 18311

45.038

86.985

0.392
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.603

84.064

0.392

Multiple sequence alignment