Detailed information NTG0195508

Bioinformatically predicted

Overview

• Name: braS
• Type: Regulator
• Locus tag: A2U18_RS14155
• Genome accession: NZ_CP017091
• Coordinates: 2727028..2727915 (-)
• Length: 295 a.a.
• NCBI ID: WP_000143420.1
• Uniprot ID: A0A2S6DP21
• Organism: Staphylococcus aureus strain ISU926 isolate ST398
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2722028..2732915

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A2U18_RS14120 (A2U18_13755)	-	2722037..2722129 (+)	93	WP_031774855.1	hypothetical protein	-
A2U18_RS14125 (A2U18_13760)	-	2722237..2722734 (-)	498	WP_001065267.1	glutathione peroxidase	-
A2U18_RS14130 (A2U18_13765)	-	2722744..2723004 (-)	261	WP_014937088.1	hypothetical protein	-
A2U18_RS14140 (A2U18_13770)	-	2723386..2723499 (-)	114	WP_014937089.1	hypothetical protein	-
A2U18_RS14145 (A2U18_13780)	-	2724168..2726168 (-)	2001	WP_000776741.1	ABC transporter permease	-
A2U18_RS14150 (A2U18_13785)	-	2726165..2726920 (-)	756	WP_000923768.1	ABC transporter ATP-binding protein	-
A2U18_RS14155 (A2U18_13790)	braS	2727028..2727915 (-)	888	WP_000143420.1	nisin susceptibility-associated two-component system sensor histidine kinase NsaS	Regulator
A2U18_RS14160 (A2U18_13795)	braR	2727926..2728591 (-)	666	WP_000697873.1	nisin susceptibility-associated two-component system response regulator NsaR	Regulator
A2U18_RS14165 (A2U18_13800)	-	2728617..2728817 (-)	201	WP_000604731.1	hypothetical protein	-
A2U18_RS14170 (A2U18_13810)	-	2729015..2730439 (+)	1425	WP_000953736.1	alkaline phosphatase	-
A2U18_RS15040 (A2U18_13815)	-	2730499..2730600 (-)	102	WP_000731972.1	SE2200 family small protein	-
A2U18_RS14180 (A2U18_13820)	-	2730722..2731177 (-)	456	WP_000106185.1	MarR family winged helix-turn-helix transcriptional regulator	-
A2U18_RS14185 (A2U18_13825)	-	2731421..2732182 (-)	762	WP_000323448.1	alpha/beta hydrolase	-

Sequence

Protein

• Length: 295 a.a.
• Molecular weight: 34045.32 Da
• Isoelectric Point: 5.8962

>NTDB_id=195508 A2U18_RS14155 WP_000143420.1 2727028..2727915(-) (braS) [Staphylococcus aureus strain ISU926 isolate ST398]
MTFLKSITQEIAIVIVIFALFGLMFYLYHLPLEAYLLALGVILLLLLIFIGIKYLSFVKTISQQQQIENLENALYQLKNE
QIEYKNDVESYFLTWVHQMKTPITAAQLLLERDEPNVVNRVRQEVIQIDNYTSLALSYLKLLNETSDISVTKISINNIIR
PIIMKYSIQFIDQKTKIHYEPCHHEVLTDVRWTSLMIEQLINNALKYARGKDIWIEFDEQSNQLYVKDNGIGISEADLPK
IFDKGYSGYNGQRQSNSSGIGLFIVKQISTHTNHPVSVVSKQNEGTTFTIQFPDE

Nucleotide

• Length: 888 bp

>NTDB_id=195508 A2U18_RS14155 WP_000143420.1 2727028..2727915(-) (braS) [Staphylococcus aureus strain ISU926 isolate ST398]
ATGACCTTTCTTAAAAGTATTACTCAGGAAATAGCAATAGTCATAGTTATTTTTGCTTTATTTGGCTTAATGTTTTACCT
GTATCATTTGCCATTAGAAGCATATTTACTAGCACTTGGCGTTATTTTATTATTATTACTCATATTTATAGGTATTAAAT
ATTTAAGTTTTGTAAAAACTATAAGCCAACAACAACAAATTGAAAACTTAGAAAATGCGTTGTATCAGCTTAAAAATGAA
CAAATTGAATATAAAAATGATGTAGAGAGCTACTTTTTAACATGGGTACATCAAATGAAAACACCCATTACTGCAGCACA
ACTGTTACTTGAAAGAGATGAGCCTAATGTTGTGAATCGTGTTCGTCAAGAGGTTATTCAAATTGATAACTATACAAGTT
TAGCACTTAGTTATTTAAAGTTATTAAATGAAACTTCTGATATTTCTGTCACTAAAATTTCGATTAACAATATCATTCGC
CCAATTATTATGAAATATTCAATACAGTTTATTGATCAAAAAACAAAAATCCATTATGAACCTTGTCATCACGAAGTATT
AACTGACGTTAGATGGACCTCTTTAATGATAGAACAATTAATAAATAATGCACTTAAGTATGCGAGAGGTAAAGATATAT
GGATTGAATTTGATGAGCAATCCAATCAATTATACGTAAAAGATAATGGTATCGGTATTAGTGAAGCGGACTTGCCTAAA
ATATTTGATAAGGGCTATTCAGGTTATAATGGCCAGCGGCAAAGTAACTCAAGTGGGATTGGTTTATTTATCGTAAAACA
AATTTCAACTCACACAAACCATCCTGTTTCAGTCGTATCTAAACAAAATGAGGGTACAACATTTACGATTCAATTTCCAG
ATGAATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (191-294)

3D structure

• AlphaFold DB: A0A2S6DP21

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
braS	Staphylococcus aureus N315	99.322	100	0.993