Detailed information NTG0195461

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: A2V17_RS10430
• Genome accession: NZ_CP017090
• Coordinates: 2036789..2037832 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ISU935 isolate ST5
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2031789..2042832

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A2V17_RS10400 (A2V17_10250)	-	2032210..2033466 (-)	1257	WP_001795108.1	aminopeptidase	-
A2V17_RS10405 (A2V17_10255)	-	2033469..2033669 (-)	201	WP_088401755.1	DUF1128 family protein	-
A2V17_RS10410 (A2V17_10260)	-	2033816..2034280 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
A2V17_RS10415 (A2V17_10265)	-	2034287..2034562 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
A2V17_RS10420 (A2V17_10270)	-	2034840..2036057 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
A2V17_RS10425 (A2V17_10275)	vraR	2036170..2036799 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
A2V17_RS10430 (A2V17_10280)	vraS	2036789..2037832 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
A2V17_RS10435 (A2V17_10285)	liaF	2037829..2038530 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
A2V17_RS10440 (A2V17_10290)	-	2038545..2038931 (-)	387	WP_001110179.1	hypothetical protein	-
A2V17_RS10445 (A2V17_10295)	map	2039148..2039906 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
A2V17_RS10455 (A2V17_10305)	-	2040437..2041423 (+)	987	WP_000999717.1	FUSC family protein	-
A2V17_RS10460 (A2V17_10310)	-	2041854..2042267 (-)	414	WP_001557448.1	hypothetical protein	-
A2V17_RS10465 (A2V17_10315)	-	2042296..2042406 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=195461 A2V17_RS10430 WP_001017131.1 2036789..2037832(-) (vraS) [Staphylococcus aureus strain ISU935 isolate ST5]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=195461 A2V17_RS10430 WP_001017131.1 2036789..2037832(-) (vraS) [Staphylococcus aureus strain ISU935 isolate ST5]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1