Detailed information NTG0195419

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: A7J08_RS09085
• Genome accession: NZ_CP017088
• Coordinates: 1819431..1821881 (-)
• Length: 816 a.a.
• NCBI ID: WP_053867208.1
• Uniprot ID: A0A3Q8C1W7
• Organism: Streptococcus suis strain SRD478
• Function: degradation of ComW (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1817118..1826159	1819431..1821881	within	0

Gene organization within MGE regions

Location: 1817118..1826159

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7J08_RS09070 (A7J08_08825)	dusB	1817118..1818122 (+)	1005	WP_053867485.1	tRNA dihydrouridine synthase DusB	-
A7J08_RS09075 (A7J08_08830)	-	1818227..1818715 (-)	489	WP_053867484.1	adenylyltransferase/cytidyltransferase family protein	-
A7J08_RS09080 (A7J08_08835)	-	1818764..1819261 (-)	498	WP_079739265.1	GNAT family N-acetyltransferase	-
A7J08_RS09085 (A7J08_08840)	clpC	1819431..1821881 (-)	2451	WP_053867208.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
A7J08_RS09090 (A7J08_08845)	-	1821885..1822343 (-)	459	WP_002937810.1	CtsR family transcriptional regulator	-
A7J08_RS09095 (A7J08_08850)	-	1822614..1822952 (+)	339	WP_053867207.1	thioredoxin domain-containing protein	-
A7J08_RS09100 (A7J08_08855)	-	1823199..1823819 (-)	621	WP_024388570.1	FctA domain-containing protein	-
A7J08_RS09105 (A7J08_08860)	srtB	1823856..1824563 (-)	708	WP_024388569.1	class B sortase	-
A7J08_RS09110 (A7J08_08865)	-	1824580..1825596 (-)	1017	WP_053867206.1	QVPTGV class sortase B protein-sorting domain-containing protein	-
A7J08_RS09115 (A7J08_08870)	lepB	1825617..1826159 (-)	543	WP_079739264.1	signal peptidase I	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90446.99 Da
• Isoelectric Point: 6.1687

>NTDB_id=195419 A7J08_RS09085 WP_053867208.1 1819431..1821881(-) (clpC) [Streptococcus suis strain SRD478]
MKISTGLQRVFEDAQLVAQRYACDYLETWHVLLSFVINHDTVAGAVLAEYPISISDYEHATFVVTDKVYREELDSFRILP
SSKRLDETASFAKKIAEVVKAKELGTEHLFMAMLLDKRSTASQILDKVGFYFEDSDDKFRFLDLRKNLEARAGFTKEDLK
AIRSVMKGGKAKPTNMGQMMGMPPAPQSGGLEDYTRDLTALAREGKIEPVIGRDAEIARMIQILSRKTKNNPVLVGDAGV
GKTALALGLAQRVAAGDVPVSLAKMRVLELDLMNVIAGTRFRGDFEERMNNIINDIEEDGQVILFIDELHTIMGSGSGID
STLDAANILKPALARGTLRTVGATTQTEYQKHIEKDAALVRRFAKVTIEEPTVEDSIAILTGLKGTFEKYHRVRIGNTAV
ETAVTYAKRYLTSKNLPDSAIDLLDEASATVQNRVKGQAEETGLTSIDKALMDKKYKTVSKLLIKTKEDAEASQNYDLEV
TEEDVLETLSRLSGIPVAKLSQSDTKKYLNLEAELHKRVIGQEEAISAVSRAIRRNQSGIRTGRRPIGSFMFLGPTGVGK
TELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLL
QVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGALDLSKDHKEVEKRIFEELKKAYRPEFINRIDEKVVF
HSLTETHMQDVVKVMIKPLLAITAEKGITLKLQPSALKLLAKQGYDPEMGARPLRRLLQTKLEDPLAEMLLRGDLATGST
LKVGVKGEELKFDIVI

Nucleotide

• Length: 2451 bp

>NTDB_id=195419 A7J08_RS09085 WP_053867208.1 1819431..1821881(-) (clpC) [Streptococcus suis strain SRD478]
ATGAAAATTTCAACTGGTTTACAGCGGGTTTTTGAAGATGCCCAGTTAGTGGCCCAACGTTATGCCTGTGATTACTTGGA
AACCTGGCATGTGCTCTTGTCTTTCGTTATCAACCATGATACAGTCGCCGGCGCTGTTTTGGCAGAATATCCTATTTCAA
TTTCTGACTATGAACATGCAACTTTTGTTGTGACCGACAAGGTCTATCGTGAAGAGTTGGATAGTTTTCGTATTTTACCA
TCTTCTAAACGTTTGGATGAAACGGCTAGTTTTGCCAAGAAAATTGCAGAAGTTGTCAAGGCTAAGGAGCTGGGAACGGA
GCATTTGTTTATGGCTATGTTGTTGGACAAGCGGTCAACAGCTAGTCAGATTTTGGACAAGGTAGGTTTTTATTTTGAAG
ACTCAGATGATAAGTTTCGTTTCTTGGACTTGCGTAAAAACTTGGAGGCACGTGCGGGATTTACCAAAGAGGACCTTAAA
GCTATCCGCAGTGTGATGAAGGGTGGCAAAGCCAAACCTACTAATATGGGACAGATGATGGGAATGCCCCCAGCACCTCA
AAGTGGTGGATTAGAAGACTACACTCGTGATTTGACAGCTTTGGCGCGTGAAGGGAAGATTGAACCTGTCATCGGTCGAG
ACGCTGAGATTGCACGGATGATCCAAATTCTATCACGTAAAACCAAGAACAACCCAGTTCTGGTTGGTGATGCAGGTGTC
GGAAAAACTGCGCTTGCTTTGGGTCTTGCTCAACGTGTTGCTGCAGGTGATGTCCCTGTCAGCTTGGCTAAGATGCGGGT
TTTGGAACTTGACTTGATGAACGTTATCGCTGGAACTCGTTTCCGTGGTGATTTCGAAGAACGGATGAATAATATCATCA
ACGATATCGAGGAAGATGGTCAGGTCATCCTCTTCATCGATGAGTTGCATACCATTATGGGTTCAGGGTCAGGGATTGAT
TCGACACTGGACGCAGCCAATATCCTCAAACCAGCTCTTGCTCGTGGCACCCTCCGTACGGTCGGAGCGACAACTCAGAC
AGAGTATCAAAAGCATATTGAGAAAGACGCAGCCCTGGTTCGTCGTTTTGCCAAAGTGACCATTGAAGAGCCGACAGTGG
AAGATAGCATTGCCATTTTGACTGGTTTAAAAGGTACTTTTGAGAAATACCACAGGGTCCGTATTGGAAATACGGCTGTA
GAGACTGCTGTGACCTACGCTAAGCGGTATTTGACCAGTAAAAACCTGCCAGATTCTGCCATTGATCTGCTGGATGAAGC
CAGTGCAACGGTACAAAATCGAGTGAAAGGGCAGGCTGAGGAAACGGGACTGACGAGTATTGACAAGGCCTTGATGGATA
AAAAATATAAGACTGTCAGCAAGCTTTTGATTAAAACGAAAGAAGATGCCGAGGCTAGTCAAAACTATGACCTTGAAGTA
ACAGAAGAAGATGTTTTAGAAACACTTAGCCGCTTGTCGGGTATCCCAGTAGCCAAGCTCAGTCAGTCAGATACCAAGAA
ATATCTGAATTTGGAAGCAGAACTGCATAAACGTGTCATCGGTCAAGAAGAAGCTATTTCTGCAGTTAGCAGAGCTATTC
GCCGTAATCAGTCAGGGATTCGTACAGGTCGCAGACCGATTGGTTCCTTTATGTTCTTGGGACCAACTGGTGTTGGTAAG
ACAGAGCTTGCTAAGGCCTTGGCAGAAGTTCTCTTTGATGACGAATCTGCTCTTATCCGTTTTGATATGTCTGAATACAT
GGAGAAATTCGCAGCCAGCCGTTTAAACGGTGCCCCTCCGGGCTATGTGGGCTATGAGGAAGGTGGCGAATTGACAGAAA
AAGTTCGTAACAAACCTTATTCTGTTCTTCTTTTTGATGAGGTTGAAAAGGCTCATCCAGATATTTTCAATGTTCTCTTG
CAGGTCTTGGATGATGGTGTTCTGACAGACAGTAAGGGACGTAAGGTTGATTTCTCAAATACCATTATTATCATGACGTC
AAACCTTGGAGCAACAGCCCTTCGTGATGATAAGACAGTTGGTTTTGGTGCCCTTGATTTATCTAAGGACCACAAGGAAG
TGGAGAAACGTATTTTTGAGGAATTGAAAAAAGCCTATCGTCCAGAATTTATCAACCGTATTGACGAGAAAGTTGTCTTC
CATAGCCTAACGGAAACTCATATGCAGGATGTTGTCAAGGTCATGATTAAACCGTTGTTAGCTATAACAGCTGAGAAAGG
AATTACCCTTAAACTGCAACCGTCAGCCCTCAAGTTATTGGCTAAACAAGGTTACGACCCAGAAATGGGAGCTCGTCCTC
TTCGTAGACTCTTACAAACCAAATTGGAAGATCCGTTAGCAGAAATGTTGCTCCGTGGTGACTTGGCTACTGGTTCGACC
TTGAAGGTTGGGGTAAAGGGCGAAGAACTCAAGTTTGATATCGTCATTTAG

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-803)

• ATPase family associated with various cellular activities (AAA) (AAA) (233-365)

• AAA lid domain (AAA_lid_9) (372-457)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (102-130)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-56)

3D structure

• AlphaFold DB: A0A3Q8C1W7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae Rx1	72.025	99.877	0.719
clpC	Streptococcus pneumoniae D39	72.025	99.877	0.719
clpC	Streptococcus pneumoniae TIGR4	72.025	99.877	0.719
clpC	Streptococcus mutans UA159	66.83	99.755	0.667
clpC	Streptococcus thermophilus LMD-9	63.723	100	0.654
clpC	Streptococcus thermophilus LMG 18311	64.14	100	0.653
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.987	100	0.504
clpC	Bacillus subtilis subsp. subtilis str. 168	43.353	100	0.444