Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   A7J08_RS02750 Genome accession   NZ_CP017088
Coordinates   526756..528984 (-) Length   742 a.a.
NCBI ID   WP_053866812.1    Uniprot ID   A0A3Q8B7N4
Organism   Streptococcus suis strain SRD478     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 521756..533984
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A7J08_RS02730 (A7J08_02630) - 522320..522763 (+) 444 WP_024393138.1 GNAT family N-acetyltransferase -
  A7J08_RS02735 (A7J08_02635) ileS 522774..525563 (+) 2790 WP_053866810.1 isoleucine--tRNA ligase -
  A7J08_RS02740 (A7J08_02640) - 525746..526054 (-) 309 WP_002938710.1 DUF1827 family protein -
  A7J08_RS02745 (A7J08_02645) - 526109..526570 (-) 462 WP_053866811.1 NUDIX hydrolase -
  A7J08_RS02750 (A7J08_02650) clpE 526756..528984 (-) 2229 WP_053866812.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  A7J08_RS02755 (A7J08_02655) - 529208..529438 (+) 231 WP_002938704.1 DUF1797 family protein -
  A7J08_RS02760 (A7J08_02660) - 529564..530253 (+) 690 WP_002938702.1 amino acid ABC transporter permease -
  A7J08_RS02765 (A7J08_02665) - 530246..530980 (+) 735 WP_002943067.1 amino acid ABC transporter ATP-binding protein -
  A7J08_RS02770 (A7J08_02670) - 531110..531958 (+) 849 WP_044752945.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  A7J08_RS02780 (A7J08_02680) - 533387..533686 (+) 300 WP_053866813.1 hypothetical protein -

Sequence

Protein


Download         Length: 742 a.a.        Molecular weight: 82566.93 Da        Isoelectric Point: 5.2782

>NTDB_id=195392 A7J08_RS02750 WP_053866812.1 526756..528984(-) (clpE) [Streptococcus suis strain SRD478]
MLCKNCNINDATIHLYTNLNGKQQQVDLCHNCYQIMKTDPNNAILRGLGDLTNPNNMDPFSEFFNHLGGYPGNTPAGKNR
EQTPPTQAGGHNGRGGQAPPPQQPQQPNGLLEEFGINVTEIARRGDIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGV
GKTAVVEGLAQKIVDGDVPQKLRDKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRREIILFIDEIHEIVGAGSAGD
GNMDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVEEPSVEETITILKGIQNKYQDYHHVKYSDAAIE
AAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFIDPKEIDQRLIDAENRKAQATRDEDYEKAAYFRDQIAKYKEMQK
ATISEEDIPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLVNLASDLKAHVIGQDEAVDKIAKAIRRNRVGLGAPNRPIGS
FLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVE
KAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAMEGRTQSVLGQLSNFFTPEFMNRFDG
IIEFQPLSKENLLEIVSLMLDDVNKRLSHNGISLHVTDKVKEKLVDLGYDPKMGARPLRRTIQDQIEDAITDFYLEHPAE
KDLRAVMSSKGTIQIKAQTKTK

Nucleotide


Download         Length: 2229 bp        

>NTDB_id=195392 A7J08_RS02750 WP_053866812.1 526756..528984(-) (clpE) [Streptococcus suis strain SRD478]
ATGCTCTGCAAAAATTGTAATATCAACGACGCAACGATCCATCTCTACACCAACTTAAACGGTAAACAGCAGCAGGTAGA
CCTCTGTCACAACTGCTACCAAATCATGAAAACAGACCCTAATAATGCCATCCTACGTGGGTTGGGAGATTTAACAAATC
CTAACAATATGGATCCCTTTAGTGAATTCTTCAATCACCTAGGTGGCTATCCTGGCAATACCCCTGCTGGAAAAAATCGC
GAACAGACTCCTCCCACTCAAGCCGGTGGACATAATGGACGTGGTGGACAGGCCCCTCCTCCGCAACAACCCCAACAACC
AAATGGACTCCTTGAAGAATTTGGTATCAACGTTACCGAAATTGCCCGTCGTGGGGATATTGATCCAGTAATCGGTCGCG
ATCAAGAAATTACCCGTGTCATCGAAATTCTCAACCGTCGTACAAAAAACAACCCTGTTCTTATCGGTGAGCCTGGTGTA
GGTAAAACAGCGGTTGTTGAAGGCTTGGCTCAAAAAATTGTCGATGGCGATGTCCCACAGAAATTACGAGACAAGGAGGT
CATTCGTCTGGACGTTGTCAGCCTCGTACAAGGAACAGGTATCCGTGGACAATTTGAAGAACGCATGCAAAAACTCATGG
AAGAAATCCGTAATCGTCGCGAAATCATTCTTTTTATTGACGAGATTCACGAAATTGTCGGTGCTGGCTCTGCAGGCGAT
GGTAACATGGATGCAGGCAATATCCTCAAACCAGCCCTCGCACGTGGTGAAATGCAACTAGTCGGTGCAACAACGCTCAA
CGAGTACCGTATTATCGAAAAAGATGCCGCCCTAGAACGCCGTATGCAACCTGTAAAAGTTGAAGAACCAAGTGTCGAAG
AAACCATTACCATCCTCAAAGGTATCCAAAATAAATACCAGGATTACCATCATGTTAAATACTCCGATGCTGCTATCGAA
GCTGCTGCAGTACTGTCCAACCGCTACATTCAAGACCGTTTCCTACCAGACAAAGCTATTGACCTTCTGGATGAAGCTGG
TTCAAAAATGAATTTGACCCTCAACTTTATTGATCCAAAGGAAATTGACCAACGCCTGATTGATGCCGAAAATCGGAAAG
CACAAGCTACACGGGATGAGGACTATGAAAAAGCAGCCTATTTCCGTGACCAAATTGCTAAGTACAAGGAGATGCAAAAG
GCAACTATCAGCGAGGAAGATATTCCACTCATTACTGAAAAAGAAATTGAAGCCATCGTTGAGCAAAAAACAAATATCCC
AGTTGGTGATTTAAAAGAAAAGGAACAGTCCCAGCTTGTGAACCTCGCTAGTGACTTAAAAGCCCATGTTATCGGACAAG
ATGAAGCAGTTGACAAGATAGCTAAAGCCATCCGCCGTAATCGTGTCGGTCTCGGTGCTCCAAATCGTCCCATTGGATCC
TTCCTCTTTGTCGGACCAACAGGTGTCGGTAAAACCGAATTGTCTAAGCAATTAGCTATCGAACTCTTCGGTTCGGCTGA
CAGCATGATCCGCTTCGACATGTCCGAATACATGGAAAAACACGCTGTAGCTAAACTCGTCGGAGCTCCTCCAGGCTATG
TAGGCTATGAGGAGGCTGGACAATTGACTGAAAAAGTCCGTCGTAATCCTTACTCACTCATCCTCCTTGACGAAGTTGAA
AAAGCCCACCCAGATGTCATGCACATGTTCCTTCAGGTCTTAGACGATGGGCGTCTGACAGATGGACAAGGTCGGACAGT
CAGCTTCAAAGATACCATTATCATCATGACATCAAATGCTGGTACTGGAAAAGTTGAAGCAAGTGTCGGTTTTGGTGCGG
CTATGGAAGGGCGGACTCAATCAGTCCTTGGCCAACTTAGCAATTTCTTCACACCTGAATTTATGAACCGATTTGACGGT
ATTATTGAGTTCCAACCACTGAGCAAGGAAAACCTACTTGAAATCGTCAGCCTCATGCTAGACGATGTAAACAAACGCCT
TTCTCACAATGGCATCAGCCTCCATGTAACAGATAAAGTTAAGGAGAAATTAGTGGACCTTGGCTACGATCCAAAGATGG
GAGCTCGTCCACTACGCAGAACCATCCAAGATCAGATTGAAGATGCTATCACCGACTTCTACTTAGAACATCCAGCAGAA
AAAGACCTACGTGCTGTCATGTCAAGTAAAGGTACAATTCAAATCAAGGCACAAACAAAGACAAAATAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(476-639)

AAA lid domain (AAA_lid_9)

(291-389)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(647-721)

ATPase family associated with various cellular activities (AAA) (AAA)

(153-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3Q8B7N4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

82.205

100

0.834
  clpE Streptococcus pneumoniae D39

82.205

100

0.834
  clpE Streptococcus pneumoniae R6

82.205

100

0.834
  clpE Streptococcus pneumoniae TIGR4

82.205

100

0.834
  clpE Streptococcus mutans UA159

82.377

100

0.832
  clpC Lactococcus lactis subsp. cremoris KW2

77.655

97.709

0.759
  clpC Bacillus subtilis subsp. subtilis str. 168

52.462

87.601

0.46
  clpC Streptococcus mutans UA159

48.558

84.097

0.408
  clpC Streptococcus thermophilus LMD-9

48.248

84.636

0.408
  clpC Streptococcus thermophilus LMG 18311

47.93

84.636

0.406
  clpC Streptococcus pneumoniae TIGR4

47.84

84.232

0.403
  clpC Streptococcus pneumoniae Rx1

47.84

84.232

0.403
  clpC Streptococcus pneumoniae D39

47.84

84.232

0.403
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.815

84.636

0.396

Multiple sequence alignment