Detailed information NTG0192923

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: A7U47_RS11895
• Genome accession: NZ_CP016858
• Coordinates: 2225730..2226773 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 1971.C01
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2220730..2231773

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7U47_RS11850 (A7U47_04875)	-	2221100..2221210 (+)	111	WP_001790257.1	hypothetical protein	-
A7U47_RS11855 (A7U47_0884)	-	2221239..2221652 (+)	414	WP_001549145.1	hypothetical protein	-
A7U47_RS11865 (A7U47_0885)	-	2222142..2223128 (-)	987	WP_000999713.1	FUSC family protein	-
A7U47_RS11880 (A7U47_0886)	map	2223656..2224414 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
A7U47_RS11885 (A7U47_0887)	-	2224631..2225017 (+)	387	WP_001110179.1	hypothetical protein	-
A7U47_RS11890 (A7U47_0888)	liaF	2225032..2225733 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
A7U47_RS11895 (A7U47_0889)	vraS	2225730..2226773 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
A7U47_RS11900 (A7U47_0891)	vraR	2226763..2227392 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
A7U47_RS11905 (A7U47_0892)	-	2227508..2228725 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
A7U47_RS11910 (A7U47_0893)	-	2229003..2229278 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
A7U47_RS11915 (A7U47_0894)	-	2229285..2229749 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
A7U47_RS11920 (A7U47_0895)	-	2229896..2230096 (+)	201	WP_000180461.1	DUF1128 family protein	-
A7U47_RS11925 (A7U47_0896)	-	2230099..2231355 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=192923 A7U47_RS11895 WP_001017131.1 2225730..2226773(+) (vraS) [Staphylococcus aureus strain 1971.C01]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=192923 A7U47_RS11895 WP_001017131.1 2225730..2226773(+) (vraS) [Staphylococcus aureus strain 1971.C01]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1